Cross-talk between inflammation and coagulation

Take-home messages

- Coagulation and inflammation are closely linked and the FXII-driven contact activation system is an example for this inti-mate crosstalk.

- Platelet-released polyP forms nanoparticles that are retained on platelet surfaces where they directly initiate FXII activation..

- A routine assay for platelet polyP exists and may be used to establish the polymer as a biomarker for thrombosis.

- Targeting polyP protects from thrombosis in an FXII-dependent manner in vivo without elevating the bleeding risk.