Cross-species functional alignment reveals evolutionary hierarchy within the connectome
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Cross-species functional alignment reveals evolutionary hierarchy within the connectome. / Xu, Ting; Nenning, Karl-Heinz; Schwartz, Ernst; Hong, Seok-Jun; Vogelstein, Joshua T; Goulas, Alexandros; Fair, Damien A; Schroeder, Charles E; Margulies, Daniel S; Smallwood, Jonny; Milham, Michael P; Langs, Georg.
In: NEUROIMAGE, Vol. 223, 12.2020, p. 117346.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cross-species functional alignment reveals evolutionary hierarchy within the connectome
AU - Xu, Ting
AU - Nenning, Karl-Heinz
AU - Schwartz, Ernst
AU - Hong, Seok-Jun
AU - Vogelstein, Joshua T
AU - Goulas, Alexandros
AU - Fair, Damien A
AU - Schroeder, Charles E
AU - Margulies, Daniel S
AU - Smallwood, Jonny
AU - Milham, Michael P
AU - Langs, Georg
N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution - even within subnetworks.
AB - Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution - even within subnetworks.
U2 - 10.1016/j.neuroimage.2020.117346
DO - 10.1016/j.neuroimage.2020.117346
M3 - SCORING: Journal article
C2 - 32916286
VL - 223
SP - 117346
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -
