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Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.

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Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. / Holstege, Henne; van Beers, Erik; Velds, Arno; Liu, Xiaoling; Joosse, Simon; Klarenbeek, Sjoerd; Schut, Eva; Kerkhoven, Ron; Klijn, Christiaan N; Wessels, Lodewyk F A; Nederlof, Petra M; Jonkers, Jos.

In: BMC CANCER, Vol. 10, 2010, p. 455.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Holstege, H, van Beers, E, Velds, A, Liu, X, Joosse, S, Klarenbeek, S, Schut, E, Kerkhoven, R, Klijn, CN, Wessels, LFA, Nederlof, PM & Jonkers, J 2010, 'Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.', BMC CANCER, vol. 10, pp. 455. https://doi.org/10.1186/1471-2407-10-455

APA

Holstege, H., van Beers, E., Velds, A., Liu, X., Joosse, S., Klarenbeek, S., Schut, E., Kerkhoven, R., Klijn, C. N., Wessels, L. F. A., Nederlof, P. M., & Jonkers, J. (2010). Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC CANCER, 10, 455. https://doi.org/10.1186/1471-2407-10-455

Vancouver

Holstege H, van Beers E, Velds A, Liu X, Joosse S, Klarenbeek S et al. Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers. BMC CANCER. 2010;10:455. https://doi.org/10.1186/1471-2407-10-455

Bibtex

@article{82e401f720ae4e87a7ecba36fc387587,
title = "Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.",
abstract = "Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give rise to cellular growth advantage. So far, it has not been easy to identify the driver genes underlying gains and losses. A powerful approach to identify these driver genes could be a cross-species comparison of array comparative genomic hybridization (aCGH) data from cognate mouse and human tumors. Orthologous regions of mouse and human tumors that are commonly gained or lost might represent essential genomic regions selected for gain or loss during tumor development.",
author = "Henne Holstege and {van Beers}, Erik and Arno Velds and Xiaoling Liu and Simon Joosse and Sjoerd Klarenbeek and Eva Schut and Ron Kerkhoven and Klijn, {Christiaan N} and Wessels, {Lodewyk F A} and Nederlof, {Petra M} and Jos Jonkers",
year = "2010",
doi = "10.1186/1471-2407-10-455",
language = "Deutsch",
volume = "10",
pages = "455",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.

AU - Holstege, Henne

AU - van Beers, Erik

AU - Velds, Arno

AU - Liu, Xiaoling

AU - Joosse, Simon

AU - Klarenbeek, Sjoerd

AU - Schut, Eva

AU - Kerkhoven, Ron

AU - Klijn, Christiaan N

AU - Wessels, Lodewyk F A

AU - Nederlof, Petra M

AU - Jonkers, Jos

PY - 2010

Y1 - 2010

N2 - Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give rise to cellular growth advantage. So far, it has not been easy to identify the driver genes underlying gains and losses. A powerful approach to identify these driver genes could be a cross-species comparison of array comparative genomic hybridization (aCGH) data from cognate mouse and human tumors. Orthologous regions of mouse and human tumors that are commonly gained or lost might represent essential genomic regions selected for gain or loss during tumor development.

AB - Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give rise to cellular growth advantage. So far, it has not been easy to identify the driver genes underlying gains and losses. A powerful approach to identify these driver genes could be a cross-species comparison of array comparative genomic hybridization (aCGH) data from cognate mouse and human tumors. Orthologous regions of mouse and human tumors that are commonly gained or lost might represent essential genomic regions selected for gain or loss during tumor development.

U2 - 10.1186/1471-2407-10-455

DO - 10.1186/1471-2407-10-455

M3 - SCORING: Zeitschriftenaufsatz

VL - 10

SP - 455

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -