Critical assessment of ideal nodal yield at pelvic lymphadenectomy to accurately diagnose prostate cancer nodal metastasis in patients undergoing radical retropubic prostatectomy.
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Critical assessment of ideal nodal yield at pelvic lymphadenectomy to accurately diagnose prostate cancer nodal metastasis in patients undergoing radical retropubic prostatectomy. / Briganti, Alberto; Chun, Felix; Salonia, Andrea; Gallina, Andrea; Zanni, Giuseppe; Scattoni, Vincenzo; Valiquette, Luc; Rigatti, Patrizio; Montorsi, Francesco; Karakiewicz, Pierre I.
In: UROLOGY, Vol. 69, No. 1, 1, 2007, p. 147-151.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Critical assessment of ideal nodal yield at pelvic lymphadenectomy to accurately diagnose prostate cancer nodal metastasis in patients undergoing radical retropubic prostatectomy.
AU - Briganti, Alberto
AU - Chun, Felix
AU - Salonia, Andrea
AU - Gallina, Andrea
AU - Zanni, Giuseppe
AU - Scattoni, Vincenzo
AU - Valiquette, Luc
AU - Rigatti, Patrizio
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I
PY - 2007
Y1 - 2007
N2 - OBJECTIVES: To study the relation between the number of removed and examined lymph nodes at pelvic lymph node dissection and the rate of lymph node invasion (LNI). METHODS: A total of 858 patients aged 45 to 85 years were predominantly treated with extended pelvic lymph node dissection before radical retropubic prostatectomy. The pretreatment prostate-specific antigen level was 0.24 to 49.9 ng/mL (median 5.8). Most lesions were Stage T1c (55.2%) or T2 (40.7%), with a biopsy Gleason sum of 6 or less (62.2%) or 7 (25.1%). Receiver operating characteristic curve coordinates were used to determine the probability of finding LNI according to the number of removed and examined lymph nodes. Moreover, the association between the number of removed lymph nodes and LNI was tested in univariate and multivariate logistic regression models. RESULTS: From 2 to 40 nodes (mean 15, median 14) were removed and examined, and 88 patients (10.3%) had LNI. The LNI rate increased with the number of removed nodes (P
AB - OBJECTIVES: To study the relation between the number of removed and examined lymph nodes at pelvic lymph node dissection and the rate of lymph node invasion (LNI). METHODS: A total of 858 patients aged 45 to 85 years were predominantly treated with extended pelvic lymph node dissection before radical retropubic prostatectomy. The pretreatment prostate-specific antigen level was 0.24 to 49.9 ng/mL (median 5.8). Most lesions were Stage T1c (55.2%) or T2 (40.7%), with a biopsy Gleason sum of 6 or less (62.2%) or 7 (25.1%). Receiver operating characteristic curve coordinates were used to determine the probability of finding LNI according to the number of removed and examined lymph nodes. Moreover, the association between the number of removed lymph nodes and LNI was tested in univariate and multivariate logistic regression models. RESULTS: From 2 to 40 nodes (mean 15, median 14) were removed and examined, and 88 patients (10.3%) had LNI. The LNI rate increased with the number of removed nodes (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 69
SP - 147
EP - 151
JO - UROLOGY
JF - UROLOGY
SN - 0090-4295
IS - 1
M1 - 1
ER -
