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Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

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Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits. / Xue, Kaizhong; Gao, Bo; Chen, Feng; Wang, Meiyun; Cheng, Jingliang; Zhang, Bing; Zhu, Wenzhen; Qiu, Shijun; Geng, Zuojun; Zhang, Xiaochu; Cui, Guangbin; Yu, Yongqiang; Zhang, Quan; Liao, Weihua; Zhang, Hui; Xu, Xiaojun; Han, Tong; Qin, Wen; Liu, Feng; Liang, Meng; Guo, Lining; Xu, Qiang; Xu, Jiayuan; Fu, Jilian; Zhang, Peng; Li, Wei; Shi, Dapeng; Wang, Caihong; Lui, Su; Yan, Zhihan; Zhang, Jing; Li, Jiance; Wang, Dawei; Xian, Junfang; Xu, Kai; Zuo, Xi-Nian; Zhang, Longjiang; Ye, Zhaoxiang; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Artiges, Eric; Nees, Frauke; Orfanos, Dimitri Papadopoulos; Lemaitre, Herve; Poustka, Luise; Hohmann, Sarah; Holz, Nathalie; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Shen, Wen; Miao, Yanwei; Yu, Chunshui; IMAGEN Consortium; CHIMGEN Consortium.

In: MOL PSYCHIATR, Vol. 28, No. 11, 11.2023, p. 4853-4866.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Xue, K, Gao, B, Chen, F, Wang, M, Cheng, J, Zhang, B, Zhu, W, Qiu, S, Geng, Z, Zhang, X, Cui, G, Yu, Y, Zhang, Q, Liao, W, Zhang, H, Xu, X, Han, T, Qin, W, Liu, F, Liang, M, Guo, L, Xu, Q, Xu, J, Fu, J, Zhang, P, Li, W, Shi, D, Wang, C, Lui, S, Yan, Z, Zhang, J, Li, J, Wang, D, Xian, J, Xu, K, Zuo, X-N, Zhang, L, Ye, Z, Banaschewski, T, Barker, GJ, Bokde, ALW, Desrivières, S, Flor, H, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Brühl, R, Martinot, J-L, Martinot, M-LP, Artiges, E, Nees, F, Orfanos, DP, Lemaitre, H, Poustka, L, Hohmann, S, Holz, N, Fröhner, JH, Smolka, MN, Vaidya, N, Walter, H, Whelan, R, Shen, W, Miao, Y, Yu, C, IMAGEN Consortium & CHIMGEN Consortium 2023, 'Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits', MOL PSYCHIATR, vol. 28, no. 11, pp. 4853-4866. https://doi.org/10.1038/s41380-023-02261-2

APA

Xue, K., Gao, B., Chen, F., Wang, M., Cheng, J., Zhang, B., Zhu, W., Qiu, S., Geng, Z., Zhang, X., Cui, G., Yu, Y., Zhang, Q., Liao, W., Zhang, H., Xu, X., Han, T., Qin, W., Liu, F., ... CHIMGEN Consortium (2023). Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits. MOL PSYCHIATR, 28(11), 4853-4866. https://doi.org/10.1038/s41380-023-02261-2

Vancouver

Xue K, Gao B, Chen F, Wang M, Cheng J, Zhang B et al. Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits. MOL PSYCHIATR. 2023 Nov;28(11):4853-4866. https://doi.org/10.1038/s41380-023-02261-2

Bibtex

@article{6fcf197c4665436798dd9046878e5a7f,
title = "Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits",
abstract = "Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures.",
author = "Kaizhong Xue and Bo Gao and Feng Chen and Meiyun Wang and Jingliang Cheng and Bing Zhang and Wenzhen Zhu and Shijun Qiu and Zuojun Geng and Xiaochu Zhang and Guangbin Cui and Yongqiang Yu and Quan Zhang and Weihua Liao and Hui Zhang and Xiaojun Xu and Tong Han and Wen Qin and Feng Liu and Meng Liang and Lining Guo and Qiang Xu and Jiayuan Xu and Jilian Fu and Peng Zhang and Wei Li and Dapeng Shi and Caihong Wang and Su Lui and Zhihan Yan and Jing Zhang and Jiance Li and Dawei Wang and Junfang Xian and Kai Xu and Xi-Nian Zuo and Longjiang Zhang and Zhaoxiang Ye and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Sylvane Desrivi{\`e}res and Herta Flor and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and R{\"u}diger Br{\"u}hl and Jean-Luc Martinot and Martinot, {Marie-Laure Paill{\`e}re} and Eric Artiges and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Herve Lemaitre and Luise Poustka and Sarah Hohmann and Nathalie Holz and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Nilakshi Vaidya and Henrik Walter and Robert Whelan and Wen Shen and Yanwei Miao and Chunshui Yu and {IMAGEN Consortium} and {CHIMGEN Consortium}",
note = "{\textcopyright} 2023. The Author(s), under exclusive licence to Springer Nature Limited.",
year = "2023",
month = nov,
doi = "10.1038/s41380-023-02261-2",
language = "English",
volume = "28",
pages = "4853--4866",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits

AU - Xue, Kaizhong

AU - Gao, Bo

AU - Chen, Feng

AU - Wang, Meiyun

AU - Cheng, Jingliang

AU - Zhang, Bing

AU - Zhu, Wenzhen

AU - Qiu, Shijun

AU - Geng, Zuojun

AU - Zhang, Xiaochu

AU - Cui, Guangbin

AU - Yu, Yongqiang

AU - Zhang, Quan

AU - Liao, Weihua

AU - Zhang, Hui

AU - Xu, Xiaojun

AU - Han, Tong

AU - Qin, Wen

AU - Liu, Feng

AU - Liang, Meng

AU - Guo, Lining

AU - Xu, Qiang

AU - Xu, Jiayuan

AU - Fu, Jilian

AU - Zhang, Peng

AU - Li, Wei

AU - Shi, Dapeng

AU - Wang, Caihong

AU - Lui, Su

AU - Yan, Zhihan

AU - Zhang, Jing

AU - Li, Jiance

AU - Wang, Dawei

AU - Xian, Junfang

AU - Xu, Kai

AU - Zuo, Xi-Nian

AU - Zhang, Longjiang

AU - Ye, Zhaoxiang

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Brühl, Rüdiger

AU - Martinot, Jean-Luc

AU - Martinot, Marie-Laure Paillère

AU - Artiges, Eric

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Lemaitre, Herve

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Holz, Nathalie

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Vaidya, Nilakshi

AU - Walter, Henrik

AU - Whelan, Robert

AU - Shen, Wen

AU - Miao, Yanwei

AU - Yu, Chunshui

AU - IMAGEN Consortium

AU - CHIMGEN Consortium

N1 - © 2023. The Author(s), under exclusive licence to Springer Nature Limited.

PY - 2023/11

Y1 - 2023/11

N2 - Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures.

AB - Exposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear. In 4297 healthy participants (aged 18-30 years), we combined sparse multiple canonical correlation analysis with independent component analysis to identify the three-way covariation patterns of 59 preadult environmental exposures, 760 adult brain imaging phenotypes, and five personality traits, and found two robust environment-brain-personality covariation models with sex specificity. One model linked greater stress and less support to weaker functional connectivity and activity in the default mode network, stronger activity in subcortical nuclei, greater thickness and volume in the occipital, parietal and temporal cortices, and lower agreeableness, consciousness and extraversion as well as higher neuroticism. The other model linked higher urbanicity and better socioeconomic status to stronger functional connectivity and activity in the sensorimotor network, smaller volume and surface area and weaker functional connectivity and activity in the medial prefrontal cortex, lower white matter integrity, and higher openness to experience. We also conducted mediation analyses to explore the potential bidirectional mediation relationships between adult brain imaging phenotypes and personality traits with the influence of preadult environmental exposures and found both environment-brain-personality and environment-personality-brain pathways. We finally performed moderated mediation analyses to test the potential interactions between macro- and microenvironmental exposures and found that one category of exposure moderated the mediation pathways of another category of exposure. These results improve our understanding of the effects of preadult environmental exposures on the adult brain and personality traits and may facilitate the design of targeted interventions to improve mental health by reducing the impact of adverse environmental exposures.

U2 - 10.1038/s41380-023-02261-2

DO - 10.1038/s41380-023-02261-2

M3 - SCORING: Journal article

C2 - 37737484

VL - 28

SP - 4853

EP - 4866

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 11

ER -