Course of disease in patients with microscopic colitis - a European prospective incident cohort study
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Course of disease in patients with microscopic colitis - a European prospective incident cohort study. / Verhaegh, Bas P M; Münch, Andreas; Guagnozzi, Danila; Wildt, Signe; Cebula, W; Diac, A R; Fernández-Bañares, Fernando; Al-Khalaf, M A R; Pedersen, N; Kupcinskas, Juozas; Bohr, Johan; Macaigne, Gilles; Lucendo, Alfredo J; Lyutakov, Ivan; Tontini, Gian-Eugenio; Pigò, Flavia; Russo, E; Hjortswang, Henrik; Miehlke, Stephan; Munck, Lars K.
In: J CROHNS COLITIS, Vol. 15, No. 7, 05.07.2021, p. 1174-1183.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Course of disease in patients with microscopic colitis - a European prospective incident cohort study
AU - Verhaegh, Bas P M
AU - Münch, Andreas
AU - Guagnozzi, Danila
AU - Wildt, Signe
AU - Cebula, W
AU - Diac, A R
AU - Fernández-Bañares, Fernando
AU - Al-Khalaf, M A R
AU - Pedersen, N
AU - Kupcinskas, Juozas
AU - Bohr, Johan
AU - Macaigne, Gilles
AU - Lucendo, Alfredo J
AU - Lyutakov, Ivan
AU - Tontini, Gian-Eugenio
AU - Pigò, Flavia
AU - Russo, E
AU - Hjortswang, Henrik
AU - Miehlke, Stephan
AU - Munck, Lars K
N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.
PY - 2021/7/5
Y1 - 2021/7/5
N2 - BACKGROUND AND AIMS: The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and healthcare professionals on the expected course of the disease and real-life response to therapy are warranted.METHODS: A prospective, pan-European, multi-centre, web-based registry was established. Incident cases of MC were included. Data on patient characteristics, symptoms, treatment and quality of life were systematically registered at baseline and during real-time follow-up. Four disease course phenotypes were discriminated and described.RESULTS: Among 381 cases with complete 1-year follow-up, 49% had a chronic active or relapsing disease course, 40% achieved sustained remission after treatment and 11% had a quiescent course. In general, symptoms and quality of life improved after 3 months of follow-up. A relapsing or chronic active disease course was associated with significantly more symptoms and impaired quality of life after 1 year.CONCLUSIONS: A minority of MC patients follow a quiescent disease course with spontaneous clinical improvement, whereas the majority suffer a chronic active or relapsing disease course during the first year after diagnosis, with persisting symptoms accompanied by a significantly impaired quality of life.
AB - BACKGROUND AND AIMS: The disease course of microscopic colitis [MC] is considered chronic but benign. However, this assumption is based on mainly retrospective studies, reporting on incomplete follow-up of selective cohorts. Systematic, prospective and unbiased data to inform patients and healthcare professionals on the expected course of the disease and real-life response to therapy are warranted.METHODS: A prospective, pan-European, multi-centre, web-based registry was established. Incident cases of MC were included. Data on patient characteristics, symptoms, treatment and quality of life were systematically registered at baseline and during real-time follow-up. Four disease course phenotypes were discriminated and described.RESULTS: Among 381 cases with complete 1-year follow-up, 49% had a chronic active or relapsing disease course, 40% achieved sustained remission after treatment and 11% had a quiescent course. In general, symptoms and quality of life improved after 3 months of follow-up. A relapsing or chronic active disease course was associated with significantly more symptoms and impaired quality of life after 1 year.CONCLUSIONS: A minority of MC patients follow a quiescent disease course with spontaneous clinical improvement, whereas the majority suffer a chronic active or relapsing disease course during the first year after diagnosis, with persisting symptoms accompanied by a significantly impaired quality of life.
U2 - 10.1093/ecco-jcc/jjab007
DO - 10.1093/ecco-jcc/jjab007
M3 - SCORING: Journal article
C2 - 33433605
VL - 15
SP - 1174
EP - 1183
JO - J CROHNS COLITIS
JF - J CROHNS COLITIS
SN - 1873-9946
IS - 7
ER -