Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain

Katja Wiech; Falk Eippert; Joachim Vandekerckhove; Jonas Zaman; Katerina Placek; Francis Tuerlinckx; Johan Vlaeyen; Irene Tracey

doi:10.1016/j.jpain.2021.11.006

Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain

Standard

Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain. / Wiech, Katja; Eippert, Falk; Vandekerckhove, Joachim; Zaman, Jonas; Placek, Katerina; Tuerlinckx, Francis; Vlaeyen, Johan; Tracey, Irene.

In: J PAIN, Vol. 23, No. 4, 04.2022, p. 680-692.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wiech, K, Eippert, F, Vandekerckhove, J, Zaman, J, Placek, K, Tuerlinckx, F, Vlaeyen, J & Tracey, I 2022, 'Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain', J PAIN, vol. 23, no. 4, pp. 680-692. https://doi.org/10.1016/j.jpain.2021.11.006

APA

Wiech, K., Eippert, F., Vandekerckhove, J., Zaman, J., Placek, K., Tuerlinckx, F., Vlaeyen, J., & Tracey, I. (2022). Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain. J PAIN, 23(4), 680-692. https://doi.org/10.1016/j.jpain.2021.11.006

Vancouver

Wiech K, Eippert F, Vandekerckhove J, Zaman J, Placek K, Tuerlinckx F et al. Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain. J PAIN. 2022 Apr;23(4):680-692. https://doi.org/10.1016/j.jpain.2021.11.006

Bibtex

@article{e25ce09a2caa4179803cf98b7defdfac,

title = "Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain",

abstract = "Prior expectations can bias how we perceive pain. Using a drift diffusion model, we recently showed that this influence is primarily based on changes in perceptual decision-making (indexed as shift in starting point). Only during unexpected application of high-intensity noxious stimuli, altered information processing (indexed as increase in drift rate) explained the expectancy effect on pain processing. Here, we employed functional magnetic resonance imaging to investigate the neural basis of both these processes in healthy volunteers. On each trial, visual cues induced the expectation of high- or low-intensity noxious stimulation or signaled equal probability for both intensities. Participants categorized a subsequently applied electrical stimulus as either low- or high-intensity pain. A shift in starting point towards high pain correlated negatively with right dorsolateral prefrontal cortex activity during cue presentation underscoring its proposed role of {"}keeping pain out of mind{"}. This anticipatory right dorsolateral prefrontal cortex signal increase was positively correlated with periaqueductal gray (PAG) activity when the expected high-intensity stimulation was applied. A drift rate increase during unexpected high-intensity pain was reflected in amygdala engagement and increased functional connectivity between amygdala and PAG. Our findings suggest involvement of the PAG in both decision-making bias and altered information processing to implement expectancy effects on pain. PERSPECTIVE: Modulation of pain through expectations has been linked to changes in perceptual decision-making and altered processing of afferent information. Our results suggest involvement of the dorsolateral prefrontal cortex, amygdala, and periaqueductal gray in these processes.",

author = "Katja Wiech and Falk Eippert and Joachim Vandekerckhove and Jonas Zaman and Katerina Placek and Francis Tuerlinckx and Johan Vlaeyen and Irene Tracey",

note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",

year = "2022",

month = apr,

doi = "10.1016/j.jpain.2021.11.006",

language = "English",

volume = "23",

pages = "680--692",

journal = "J PAIN",

issn = "1526-5900",

publisher = "Churchill Livingstone",

number = "4",

}

RIS

TY - JOUR

T1 - Cortico-brainstem mechanisms of biased perceptual decision-making in the context of pain

AU - Wiech, Katja

AU - Eippert, Falk

AU - Vandekerckhove, Joachim

AU - Zaman, Jonas

AU - Placek, Katerina

AU - Tuerlinckx, Francis

AU - Vlaeyen, Johan

AU - Tracey, Irene

PY - 2022/4

Y1 - 2022/4

N2 - Prior expectations can bias how we perceive pain. Using a drift diffusion model, we recently showed that this influence is primarily based on changes in perceptual decision-making (indexed as shift in starting point). Only during unexpected application of high-intensity noxious stimuli, altered information processing (indexed as increase in drift rate) explained the expectancy effect on pain processing. Here, we employed functional magnetic resonance imaging to investigate the neural basis of both these processes in healthy volunteers. On each trial, visual cues induced the expectation of high- or low-intensity noxious stimulation or signaled equal probability for both intensities. Participants categorized a subsequently applied electrical stimulus as either low- or high-intensity pain. A shift in starting point towards high pain correlated negatively with right dorsolateral prefrontal cortex activity during cue presentation underscoring its proposed role of "keeping pain out of mind". This anticipatory right dorsolateral prefrontal cortex signal increase was positively correlated with periaqueductal gray (PAG) activity when the expected high-intensity stimulation was applied. A drift rate increase during unexpected high-intensity pain was reflected in amygdala engagement and increased functional connectivity between amygdala and PAG. Our findings suggest involvement of the PAG in both decision-making bias and altered information processing to implement expectancy effects on pain. PERSPECTIVE: Modulation of pain through expectations has been linked to changes in perceptual decision-making and altered processing of afferent information. Our results suggest involvement of the dorsolateral prefrontal cortex, amygdala, and periaqueductal gray in these processes.

AB - Prior expectations can bias how we perceive pain. Using a drift diffusion model, we recently showed that this influence is primarily based on changes in perceptual decision-making (indexed as shift in starting point). Only during unexpected application of high-intensity noxious stimuli, altered information processing (indexed as increase in drift rate) explained the expectancy effect on pain processing. Here, we employed functional magnetic resonance imaging to investigate the neural basis of both these processes in healthy volunteers. On each trial, visual cues induced the expectation of high- or low-intensity noxious stimulation or signaled equal probability for both intensities. Participants categorized a subsequently applied electrical stimulus as either low- or high-intensity pain. A shift in starting point towards high pain correlated negatively with right dorsolateral prefrontal cortex activity during cue presentation underscoring its proposed role of "keeping pain out of mind". This anticipatory right dorsolateral prefrontal cortex signal increase was positively correlated with periaqueductal gray (PAG) activity when the expected high-intensity stimulation was applied. A drift rate increase during unexpected high-intensity pain was reflected in amygdala engagement and increased functional connectivity between amygdala and PAG. Our findings suggest involvement of the PAG in both decision-making bias and altered information processing to implement expectancy effects on pain. PERSPECTIVE: Modulation of pain through expectations has been linked to changes in perceptual decision-making and altered processing of afferent information. Our results suggest involvement of the dorsolateral prefrontal cortex, amygdala, and periaqueductal gray in these processes.

U2 - 10.1016/j.jpain.2021.11.006

DO - 10.1016/j.jpain.2021.11.006

M3 - SCORING: Journal article

C2 - 34856408

VL - 23

SP - 680

EP - 692

JO - J PAIN

JF - J PAIN

SN - 1526-5900

IS - 4

ER -