Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis
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Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis. / Lopes, Daniella Guedes de Figueiredo; Patricio, Érica Fernanda; Assis, Neuza Maria Souza Picorelli; Coutinho-Camillo, Cláudia Malheiros; Alves, Fabio de Abreu; Kowalski, Luiz Paulo; Jähn-Rickert, Katharina; Busse, Björn; Rabelo, Gustavo Davi.
In: BRAZ ORAL RES, Vol. 37, e109, 2023.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis
AU - Lopes, Daniella Guedes de Figueiredo
AU - Patricio, Érica Fernanda
AU - Assis, Neuza Maria Souza Picorelli
AU - Coutinho-Camillo, Cláudia Malheiros
AU - Alves, Fabio de Abreu
AU - Kowalski, Luiz Paulo
AU - Jähn-Rickert, Katharina
AU - Busse, Björn
AU - Rabelo, Gustavo Davi
PY - 2023
Y1 - 2023
N2 - The objective of this study was to assess the remodeling-associated gene expression in the mandible of patients diagnosed with oral squamous cell carcinoma (OSCC), investigating the cortical microarchitecture, and their influence on disease-free survival (DFS) and overall survival (OS) rates. A total of twenty-four patients who underwent mandibulectomy for OSCC treatment had two bone fragments harvested from the mandible for gene expression (RANK, RANKL, OPG, and SOST), and microarchitecture analysis, including bone volume, surface, mineral density, degree of anisotropy, and fractal dimension. The prognosis of the patients was assessed. The results revealed that RANK, RANKL, and SOST were predominantly downregulated, while OPG was completely downregulated. Tumors located adjacent to the posterior region of the mandible (p = 0.02), with a bone mineral density below 1.03 g/cm3 HA (p = 0.001), and a bone volume less than 86.47% (p = 0.03) were associated with poor outcomes. In conclusion, bone-remodeling-associated genes exhibited downregulation in the cortex of the mandible in OSCC patients. Additionally, the tumor's location within the mandible, bone volume, and cortical bone mineral density were identified as factors impacting DFS.
AB - The objective of this study was to assess the remodeling-associated gene expression in the mandible of patients diagnosed with oral squamous cell carcinoma (OSCC), investigating the cortical microarchitecture, and their influence on disease-free survival (DFS) and overall survival (OS) rates. A total of twenty-four patients who underwent mandibulectomy for OSCC treatment had two bone fragments harvested from the mandible for gene expression (RANK, RANKL, OPG, and SOST), and microarchitecture analysis, including bone volume, surface, mineral density, degree of anisotropy, and fractal dimension. The prognosis of the patients was assessed. The results revealed that RANK, RANKL, and SOST were predominantly downregulated, while OPG was completely downregulated. Tumors located adjacent to the posterior region of the mandible (p = 0.02), with a bone mineral density below 1.03 g/cm3 HA (p = 0.001), and a bone volume less than 86.47% (p = 0.03) were associated with poor outcomes. In conclusion, bone-remodeling-associated genes exhibited downregulation in the cortex of the mandible in OSCC patients. Additionally, the tumor's location within the mandible, bone volume, and cortical bone mineral density were identified as factors impacting DFS.
KW - Humans
KW - Mouth Neoplasms/genetics
KW - Carcinoma, Squamous Cell/genetics
KW - Squamous Cell Carcinoma of Head and Neck
KW - Prognosis
KW - RANK Ligand/genetics
KW - Head and Neck Neoplasms
KW - Gene Expression
KW - Osteoprotegerin/genetics
U2 - 10.1590/1807-3107bor-2023.vol37.0109
DO - 10.1590/1807-3107bor-2023.vol37.0109
M3 - SCORING: Journal article
C2 - 37970929
VL - 37
JO - BRAZ ORAL RES
JF - BRAZ ORAL RES
SN - 1807-3107
M1 - e109
ER -
