Research ExplorerPublicationsCortical glutamate and GABA are related to compulsive behavi...

Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

Standard

Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls. / Biria, Marjan; Banca, Paula; Healy, Máiréad P; Keser, Engin; Sawiak, Stephen J; Rodgers, Christopher T; Rua, Catarina; de Souza, Ana Maria Frota Lisbôa Pereira; Marzuki, Aleya A; Sule, Akeem; Ersche, Karen D; Robbins, Trevor W.

In: NAT COMMUN, Vol. 14, No. 1, 27.06.2023, p. 3324.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Biria, M, Banca, P, Healy, MP, Keser, E, Sawiak, SJ, Rodgers, CT, Rua, C, de Souza, AMFLP, Marzuki, AA, Sule, A, Ersche, KD & Robbins, TW 2023, 'Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls', NAT COMMUN, vol. 14, no. 1, pp. 3324. https://doi.org/10.1038/s41467-023-38695-z

APA

Biria, M., Banca, P., Healy, M. P., Keser, E., Sawiak, S. J., Rodgers, C. T., Rua, C., de Souza, A. M. F. L. P., Marzuki, A. A., Sule, A., Ersche, K. D., & Robbins, T. W. (2023). Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls. NAT COMMUN, 14(1), 3324. https://doi.org/10.1038/s41467-023-38695-z

Vancouver

Biria M, Banca P, Healy MP, Keser E, Sawiak SJ, Rodgers CT et al. Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls. NAT COMMUN. 2023 Jun 27;14(1):3324. https://doi.org/10.1038/s41467-023-38695-z

Bibtex

@article{30489235bb9348558460d12d43b12412,
title = "Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls",
abstract = "There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.",
keywords = "Humans, Glutamic Acid, Obsessive-Compulsive Disorder, Proton Magnetic Resonance Spectroscopy, Compulsive Behavior, gamma-Aminobutyric Acid, Magnetic Resonance Imaging",
author = "Marjan Biria and Paula Banca and Healy, {M{\'a}ir{\'e}ad P} and Engin Keser and Sawiak, {Stephen J} and Rodgers, {Christopher T} and Catarina Rua and {de Souza}, {Ana Maria Frota Lisb{\^o}a Pereira} and Marzuki, {Aleya A} and Akeem Sule and Ersche, {Karen D} and Robbins, {Trevor W}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = jun,
day = "27",
doi = "10.1038/s41467-023-38695-z",
language = "English",
volume = "14",
pages = "3324",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

AU - Biria, Marjan

AU - Banca, Paula

AU - Healy, Máiréad P

AU - Keser, Engin

AU - Sawiak, Stephen J

AU - Rodgers, Christopher T

AU - Rua, Catarina

AU - de Souza, Ana Maria Frota Lisbôa Pereira

AU - Marzuki, Aleya A

AU - Sule, Akeem

AU - Ersche, Karen D

AU - Robbins, Trevor W

N1 - © 2023. The Author(s).

PY - 2023/6/27

Y1 - 2023/6/27

N2 - There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.

AB - There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the balance of excitatory and inhibitory neurotransmission by measuring glutamate and GABA levels in anterior cingulate cortex (ACC) and supplementary motor area (SMA) of healthy volunteers and participants with Obsessive-Compulsive Disorder (OCD). Within the SMA, trait and clinical measures of compulsive behaviour are related to glutamate levels, whereas a behavioural index of habitual control correlates with the glutamate:GABA ratio. Participants with OCD also show the latter relationship in the ACC while exhibiting elevated glutamate and lower GABA levels in that region. This study highlights SMA mechanisms of habitual control relevant to compulsive behaviour, common to the healthy sub-clinical and OCD populations. The results also demonstrate additional involvement of anterior cingulate in the balance between goal-directed and habitual responding in OCD.

KW - Humans

KW - Glutamic Acid

KW - Obsessive-Compulsive Disorder

KW - Proton Magnetic Resonance Spectroscopy

KW - Compulsive Behavior

KW - gamma-Aminobutyric Acid

KW - Magnetic Resonance Imaging

U2 - 10.1038/s41467-023-38695-z

DO - 10.1038/s41467-023-38695-z

M3 - SCORING: Journal article

C2 - 37369695

VL - 14

SP - 3324

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -