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Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.

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Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. / MacKenzie-Graham, Allan; Rinek, Gilda A; Avedisian, Andrea; Gold, Stefan; Frew, Andrew J; Aguilar, Cynthia; Lin, David R; Umeda, Elizabeth; Voskuhl, Rhonda R; Alger, Jeffry R.

In: NEUROIMAGE, Vol. 60, No. 1, 1, 2012, p. 95-104.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

MacKenzie-Graham, A, Rinek, GA, Avedisian, A, Gold, S, Frew, AJ, Aguilar, C, Lin, DR, Umeda, E, Voskuhl, RR & Alger, JR 2012, 'Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.', NEUROIMAGE, vol. 60, no. 1, 1, pp. 95-104. <http://www.ncbi.nlm.nih.gov/pubmed/22182769?dopt=Citation>

APA

MacKenzie-Graham, A., Rinek, G. A., Avedisian, A., Gold, S., Frew, A. J., Aguilar, C., Lin, D. R., Umeda, E., Voskuhl, R. R., & Alger, J. R. (2012). Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. NEUROIMAGE, 60(1), 95-104. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22182769?dopt=Citation

Vancouver

MacKenzie-Graham A, Rinek GA, Avedisian A, Gold S, Frew AJ, Aguilar C et al. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging. NEUROIMAGE. 2012;60(1):95-104. 1.

Bibtex

@article{5e6b8e3efcab4deb874f6391b566125a,
title = "Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.",
abstract = "There are strong correlations between cortical atrophy observed by MRI and clinical disability and disease duration in multiple sclerosis (MS). The objective of this study was to evaluate the progression of cortical atrophy over time in vivo in experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model for MS. Volumetric changes in brains of EAE mice and matched healthy controls were quantified by collecting high-resolution T2-weighted magnetic resonance images in vivo and labeling anatomical structures on the images. In vivo scanning permitted us to evaluate brain structure volumes in individual animals over time and we observed that though brain atrophy progressed differently in each individual animal, all mice with EAE demonstrated significant atrophy in whole brain, cerebral cortex, and whole cerebellum compared to normal controls. Furthermore, we found a strong correlation between cerebellar atrophy and cumulative disease score in mice with EAE. Ex vivo MRI showed a significant decrease in brain and cerebellar volume and a trend that did not reach significance in cerebral cortex volume in mice with EAE compared to controls. Cross modality correlations revealed a significant association between neuronal loss on neuropathology and in vivo atrophy of the cerebral cortex by neuroimaging. These results demonstrate that longitudinal in vivo imaging is more sensitive to changes that occur in neurodegenerative disease models than cross-sectional ex vivo imaging. This is the first report of progressive cortical atrophy in vivo in a mouse model of MS.",
keywords = "Animals, Mice, Atrophy, *Magnetic Resonance Imaging, Cerebral Cortex/*pathology, Cerebellum/*pathology, Encephalomyelitis, Autoimmune, Experimental/*pathology, Animals, Mice, Atrophy, *Magnetic Resonance Imaging, Cerebral Cortex/*pathology, Cerebellum/*pathology, Encephalomyelitis, Autoimmune, Experimental/*pathology",
author = "Allan MacKenzie-Graham and Rinek, {Gilda A} and Andrea Avedisian and Stefan Gold and Frew, {Andrew J} and Cynthia Aguilar and Lin, {David R} and Elizabeth Umeda and Voskuhl, {Rhonda R} and Alger, {Jeffry R}",
year = "2012",
language = "English",
volume = "60",
pages = "95--104",
journal = "NEUROIMAGE",
issn = "1053-8119",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.

AU - MacKenzie-Graham, Allan

AU - Rinek, Gilda A

AU - Avedisian, Andrea

AU - Gold, Stefan

AU - Frew, Andrew J

AU - Aguilar, Cynthia

AU - Lin, David R

AU - Umeda, Elizabeth

AU - Voskuhl, Rhonda R

AU - Alger, Jeffry R

PY - 2012

Y1 - 2012

N2 - There are strong correlations between cortical atrophy observed by MRI and clinical disability and disease duration in multiple sclerosis (MS). The objective of this study was to evaluate the progression of cortical atrophy over time in vivo in experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model for MS. Volumetric changes in brains of EAE mice and matched healthy controls were quantified by collecting high-resolution T2-weighted magnetic resonance images in vivo and labeling anatomical structures on the images. In vivo scanning permitted us to evaluate brain structure volumes in individual animals over time and we observed that though brain atrophy progressed differently in each individual animal, all mice with EAE demonstrated significant atrophy in whole brain, cerebral cortex, and whole cerebellum compared to normal controls. Furthermore, we found a strong correlation between cerebellar atrophy and cumulative disease score in mice with EAE. Ex vivo MRI showed a significant decrease in brain and cerebellar volume and a trend that did not reach significance in cerebral cortex volume in mice with EAE compared to controls. Cross modality correlations revealed a significant association between neuronal loss on neuropathology and in vivo atrophy of the cerebral cortex by neuroimaging. These results demonstrate that longitudinal in vivo imaging is more sensitive to changes that occur in neurodegenerative disease models than cross-sectional ex vivo imaging. This is the first report of progressive cortical atrophy in vivo in a mouse model of MS.

AB - There are strong correlations between cortical atrophy observed by MRI and clinical disability and disease duration in multiple sclerosis (MS). The objective of this study was to evaluate the progression of cortical atrophy over time in vivo in experimental autoimmune encephalomyelitis (EAE), the most commonly used animal model for MS. Volumetric changes in brains of EAE mice and matched healthy controls were quantified by collecting high-resolution T2-weighted magnetic resonance images in vivo and labeling anatomical structures on the images. In vivo scanning permitted us to evaluate brain structure volumes in individual animals over time and we observed that though brain atrophy progressed differently in each individual animal, all mice with EAE demonstrated significant atrophy in whole brain, cerebral cortex, and whole cerebellum compared to normal controls. Furthermore, we found a strong correlation between cerebellar atrophy and cumulative disease score in mice with EAE. Ex vivo MRI showed a significant decrease in brain and cerebellar volume and a trend that did not reach significance in cerebral cortex volume in mice with EAE compared to controls. Cross modality correlations revealed a significant association between neuronal loss on neuropathology and in vivo atrophy of the cerebral cortex by neuroimaging. These results demonstrate that longitudinal in vivo imaging is more sensitive to changes that occur in neurodegenerative disease models than cross-sectional ex vivo imaging. This is the first report of progressive cortical atrophy in vivo in a mouse model of MS.

KW - Animals

KW - Mice

KW - Atrophy

KW - Magnetic Resonance Imaging

KW - Cerebral Cortex/pathology

KW - Cerebellum/pathology

KW - Encephalomyelitis, Autoimmune, Experimental/pathology

KW - Animals

KW - Mice

KW - Atrophy

KW - Magnetic Resonance Imaging

KW - Cerebral Cortex/pathology

KW - Cerebellum/pathology

KW - Encephalomyelitis, Autoimmune, Experimental/pathology

M3 - SCORING: Journal article

VL - 60

SP - 95

EP - 104

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

IS - 1

M1 - 1

ER -