Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study
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Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study. / Yan, Ming; Ouyang, Yu-Long; Xiao, Li-Yuan; Ao, Man; Gosau, Martin; Friedrich, Reinhard E; Smeets, Ralf; Fu, Ling-Ling; Feng, Hong-Chao; Burg, Simon.
In: FRONT IMMUNOL, Vol. 14, 2023, p. 1235982.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Correlations between gut microbiota and lichen planus: a two-sample Mendelian randomization study
AU - Yan, Ming
AU - Ouyang, Yu-Long
AU - Xiao, Li-Yuan
AU - Ao, Man
AU - Gosau, Martin
AU - Friedrich, Reinhard E
AU - Smeets, Ralf
AU - Fu, Ling-Ling
AU - Feng, Hong-Chao
AU - Burg, Simon
N1 - Copyright © 2023 Yan, Ouyang, Xiao, Ao, Gosau, Friedrich, Smeets, Fu, Feng and Burg.
PY - 2023
Y1 - 2023
N2 - PURPOSE: Several existing studies have revealed that the occurrence of lichen planus (LP) is relevant to the gut microbiota, and the causal relationship between gut microbiota and LP was analyzed using the Mendelian randomization (MR) method.METHODS: Through the two-sample MR method, single nucleotide polymorphisms (SNPs) relevant to gut microbiota were selected as instrument variables (IVs) to evaluate the causal association between gut microbiota and the risk of LP.RESULTS: According to the selection criteria of inverse-variance weighted (IVW), six bacterial genera were found to be significantly linked to the initiation of LP; The IVW results suggested that Oxalobacteraceae, Victivallaceae, and Actinobacteria could restrain the initiation of LP, showing protective effects against LP. Desulfovibrio, Veillonella, and Ruminococcus gauvreauii groups were demonstrated to have casual correlations with the onset of LP.CONCLUSION: The relationship between gut microbiota and LP was not a single positive or inverse relationship. Investigation of the causal relationship of these gut microbiota with LP could further provide evidence for the intestine-skin axis theory. However, the specific mechanism of microorganisms affecting the skin remains to be clarified. In this paper, the protective effects and mechanisms of Oxalobacteraceae, Victivallaceae, and Actinobacteria on LP require further exploration.
AB - PURPOSE: Several existing studies have revealed that the occurrence of lichen planus (LP) is relevant to the gut microbiota, and the causal relationship between gut microbiota and LP was analyzed using the Mendelian randomization (MR) method.METHODS: Through the two-sample MR method, single nucleotide polymorphisms (SNPs) relevant to gut microbiota were selected as instrument variables (IVs) to evaluate the causal association between gut microbiota and the risk of LP.RESULTS: According to the selection criteria of inverse-variance weighted (IVW), six bacterial genera were found to be significantly linked to the initiation of LP; The IVW results suggested that Oxalobacteraceae, Victivallaceae, and Actinobacteria could restrain the initiation of LP, showing protective effects against LP. Desulfovibrio, Veillonella, and Ruminococcus gauvreauii groups were demonstrated to have casual correlations with the onset of LP.CONCLUSION: The relationship between gut microbiota and LP was not a single positive or inverse relationship. Investigation of the causal relationship of these gut microbiota with LP could further provide evidence for the intestine-skin axis theory. However, the specific mechanism of microorganisms affecting the skin remains to be clarified. In this paper, the protective effects and mechanisms of Oxalobacteraceae, Victivallaceae, and Actinobacteria on LP require further exploration.
U2 - 10.3389/fimmu.2023.1235982
DO - 10.3389/fimmu.2023.1235982
M3 - SCORING: Journal article
C2 - 37767099
VL - 14
SP - 1235982
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -
