Correlation of right ventricular dysfunction parameters and pulmonary vascular obstruction score in acute pulmonary embolism in a porcine model
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Correlation of right ventricular dysfunction parameters and pulmonary vascular obstruction score in acute pulmonary embolism in a porcine model. / Groth, Michael; Henes, Frank O; Müllerleile, Kai; Adam, Gerhard; Begemann, Philipp G C; Regier, Marc.
In: EMERG RADIOL, Vol. 17, No. 5, 5, 09.2010, p. 367-374.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Correlation of right ventricular dysfunction parameters and pulmonary vascular obstruction score in acute pulmonary embolism in a porcine model
AU - Groth, Michael
AU - Henes, Frank O
AU - Müllerleile, Kai
AU - Adam, Gerhard
AU - Begemann, Philipp G C
AU - Regier, Marc
PY - 2010/9
Y1 - 2010/9
N2 - This paper aims to non-invasively determine right ventricular dysfunction parameters (RVDP) in acute pulmonary embolism (APE) and to correlate these parameters with a computed tomography (CT)-based pulmonary artery obstruction score (OS). In seven domestic pigs, magnetic resonance imaging (MRI) was performed before (n = 7) and after (n = 5) APE was induced. Analysis of relative changes in right ventricular stroke volume (RVSV%), output (RVO%), end-systolic (RVESV%), end-diastolic volume (RVEDV%), and heart rate (HR%) was performed. Additionally, for the determination of the OS, all animals underwent contrast-enhanced CT-pulmonary angiography. The CT-based OS correlated strongly with RVSV% (r = 0.9576; p = 0.0104) and RVO% (r = 0.9703; p = 0.0061). Contrarily, almost no correlation could be demonstrated for the OS and the increase of RVESV % (r = 0.3850; p = 0.5222), RVEDV% (r = 0.1830; p = 0.7683), and HR% (r = 0.5494; p = 0.3375). The results of this experimental study underline that the CT-based OS correlates with RVDP as determined by cardiac MRI and might be a helpful tool for the severity assessment in APE.
AB - This paper aims to non-invasively determine right ventricular dysfunction parameters (RVDP) in acute pulmonary embolism (APE) and to correlate these parameters with a computed tomography (CT)-based pulmonary artery obstruction score (OS). In seven domestic pigs, magnetic resonance imaging (MRI) was performed before (n = 7) and after (n = 5) APE was induced. Analysis of relative changes in right ventricular stroke volume (RVSV%), output (RVO%), end-systolic (RVESV%), end-diastolic volume (RVEDV%), and heart rate (HR%) was performed. Additionally, for the determination of the OS, all animals underwent contrast-enhanced CT-pulmonary angiography. The CT-based OS correlated strongly with RVSV% (r = 0.9576; p = 0.0104) and RVO% (r = 0.9703; p = 0.0061). Contrarily, almost no correlation could be demonstrated for the OS and the increase of RVESV % (r = 0.3850; p = 0.5222), RVEDV% (r = 0.1830; p = 0.7683), and HR% (r = 0.5494; p = 0.3375). The results of this experimental study underline that the CT-based OS correlates with RVDP as determined by cardiac MRI and might be a helpful tool for the severity assessment in APE.
KW - Animals
KW - Arterial Occlusive Diseases/diagnostic imaging
KW - Disease Models, Animal
KW - Magnetic Resonance Angiography
KW - Male
KW - Pulmonary Embolism/diagnosis
KW - Radiography
KW - Research Design
KW - Swine
KW - Tomography Scanners, X-Ray Computed/trends
KW - Ventricular Dysfunction, Right/diagnostic imaging
U2 - 10.1007/s10140-010-0872-0
DO - 10.1007/s10140-010-0872-0
M3 - SCORING: Journal article
C2 - 20428913
VL - 17
SP - 367
EP - 374
JO - EMERG RADIOL
JF - EMERG RADIOL
SN - 1070-3004
IS - 5
M1 - 5
ER -
