Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study.

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Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study. / Derlin, Thorsten; Tóth, Zoltán; Papp, László; Wisotzki, Christian; Apostolova, Ivayla; Habermann, Christian; Mester, Janos; Klutmann, Susanne.

In: J NUCL MED, Vol. 52, No. 7, 7, 07.2011, p. 1020-1027.

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@article{458573360d0e416280126352b2961cb7,
title = "Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study.",
abstract = "Formation and progression of atherosclerotic plaque is a dynamic and complex process involving various pathophysiologic steps including inflammation and calcification. The purpose of this study was to compare macrophage activity as determined by (18)F-FDG PET and ongoing mineral deposition as measured by (18)F-sodium fluoride PET in atherosclerotic plaque and to correlate these findings with calcified plaque burden as assessed by CT.",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Risk Factors, Young Adult, Retrospective Studies, Radioactive Tracers, Angiography, Biological Transport, *Positron-Emission Tomography, *Tomography, X-Ray Computed, Arteries/metabolism, Calcinosis/*radiography, Fluorine Radioisotopes/diagnostic use, Fluorodeoxyglucose F18/*diagnostic use/metabolism, Inflammation/radionuclide imaging, Minerals/*metabolism, Plaque, Atherosclerotic/*diagnosis/metabolism/radiography/radionuclide imaging, Sodium Fluoride/*diagnostic use/metabolism, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Risk Factors, Young Adult, Retrospective Studies, Radioactive Tracers, Angiography, Biological Transport, *Positron-Emission Tomography, *Tomography, X-Ray Computed, Arteries/metabolism, Calcinosis/*radiography, Fluorine Radioisotopes/diagnostic use, Fluorodeoxyglucose F18/*diagnostic use/metabolism, Inflammation/radionuclide imaging, Minerals/*metabolism, Plaque, Atherosclerotic/*diagnosis/metabolism/radiography/radionuclide imaging, Sodium Fluoride/*diagnostic use/metabolism",
author = "Thorsten Derlin and Zolt{\'a}n T{\'o}th and L{\'a}szl{\'o} Papp and Christian Wisotzki and Ivayla Apostolova and Christian Habermann and Janos Mester and Susanne Klutmann",
year = "2011",
month = jul,
doi = "10.2967/jnumed.111.087452",
language = "English",
volume = "52",
pages = "1020--1027",
journal = "J NUCL MED",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - Correlation of inflammation assessed by 18F-FDG PET, active mineral deposition assessed by 18F-fluoride PET, and vascular calcification in atherosclerotic plaque: a dual-tracer PET/CT study.

AU - Derlin, Thorsten

AU - Tóth, Zoltán

AU - Papp, László

AU - Wisotzki, Christian

AU - Apostolova, Ivayla

AU - Habermann, Christian

AU - Mester, Janos

AU - Klutmann, Susanne

PY - 2011/7

Y1 - 2011/7

N2 - Formation and progression of atherosclerotic plaque is a dynamic and complex process involving various pathophysiologic steps including inflammation and calcification. The purpose of this study was to compare macrophage activity as determined by (18)F-FDG PET and ongoing mineral deposition as measured by (18)F-sodium fluoride PET in atherosclerotic plaque and to correlate these findings with calcified plaque burden as assessed by CT.

AB - Formation and progression of atherosclerotic plaque is a dynamic and complex process involving various pathophysiologic steps including inflammation and calcification. The purpose of this study was to compare macrophage activity as determined by (18)F-FDG PET and ongoing mineral deposition as measured by (18)F-sodium fluoride PET in atherosclerotic plaque and to correlate these findings with calcified plaque burden as assessed by CT.

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Risk Factors

KW - Young Adult

KW - Retrospective Studies

KW - Radioactive Tracers

KW - Angiography

KW - Biological Transport

KW - Positron-Emission Tomography

KW - Tomography, X-Ray Computed

KW - Arteries/metabolism

KW - Calcinosis/radiography

KW - Fluorine Radioisotopes/diagnostic use

KW - Fluorodeoxyglucose F18/diagnostic use/metabolism

KW - Inflammation/radionuclide imaging

KW - Minerals/metabolism

KW - Plaque, Atherosclerotic/diagnosis/metabolism/radiography/radionuclide imaging

KW - Sodium Fluoride/diagnostic use/metabolism

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Risk Factors

KW - Young Adult

KW - Retrospective Studies

KW - Radioactive Tracers

KW - Angiography

KW - Biological Transport

KW - Positron-Emission Tomography

KW - Tomography, X-Ray Computed

KW - Arteries/metabolism

KW - Calcinosis/radiography

KW - Fluorine Radioisotopes/diagnostic use

KW - Fluorodeoxyglucose F18/diagnostic use/metabolism

KW - Inflammation/radionuclide imaging

KW - Minerals/metabolism

KW - Plaque, Atherosclerotic/diagnosis/metabolism/radiography/radionuclide imaging

KW - Sodium Fluoride/diagnostic use/metabolism

U2 - 10.2967/jnumed.111.087452

DO - 10.2967/jnumed.111.087452

M3 - SCORING: Journal article

C2 - 21680686

VL - 52

SP - 1020

EP - 1027

JO - J NUCL MED

JF - J NUCL MED

SN - 0161-5505

IS - 7

M1 - 7

ER -