Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months - A Cross-Sectional Study
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Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months - A Cross-Sectional Study. / Damerau, Lukas; Mühlenbruch, Georg; Evenschor-Ascheid, Agnes; Fussen, Christine; Nienhaus, Albert; Terschüren, Claudia; Herold, Robert; Harth, Volker.
In: INT J ENV RES PUB HE, Vol. 19, No. 18, 11422, 10.09.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Coronavirus Vaccination: Spike Antibody Levels in Health Workers after Six Months - A Cross-Sectional Study
AU - Damerau, Lukas
AU - Mühlenbruch, Georg
AU - Evenschor-Ascheid, Agnes
AU - Fussen, Christine
AU - Nienhaus, Albert
AU - Terschüren, Claudia
AU - Herold, Robert
AU - Harth, Volker
PY - 2022/9/10
Y1 - 2022/9/10
N2 - Healthcare workers bear a high risk of infection during epidemics and pandemics such as the current SARS-CoV-2 pandemic. Various new vaccines have been approved. We investigated the influence of the time elapsed since vaccination, as well as of vaccination schema, on health workers’ spike antibody levels following their second vaccination. Blood samples were obtained from employees working at a German hospital between August 2021 and December 2021 on average half a year (range 130–280 days) after their second vaccination. Levels of SARS-CoV-2-IgG antibodies (spike and nucleocapsid protein) were qualitatively detected via chemiluminescent immunoassays (CLIAs). A previous infection with SARS-CoV-2 was an exclusion criterion. In total, 545 persons were included in this cross-sectional study. Most participants (97.8%) showed elevated anti-spike concentrations. Anti-spike levels differed significantly among vaccination schemas. Repeated vector vaccinations resulted in lower protective antibody levels. Higher age levels, immunosuppression and a longer time period since the second vaccination resulted in lower anti-spike levels. Women’s antibody levels were higher, but not significantly. Since anti-spike levels drop after vaccination, further boosters are required to increase immunoreactivity. If two vector vaccines have been administered, it is possible that an mRNA booster might increase the anti-spike level.
AB - Healthcare workers bear a high risk of infection during epidemics and pandemics such as the current SARS-CoV-2 pandemic. Various new vaccines have been approved. We investigated the influence of the time elapsed since vaccination, as well as of vaccination schema, on health workers’ spike antibody levels following their second vaccination. Blood samples were obtained from employees working at a German hospital between August 2021 and December 2021 on average half a year (range 130–280 days) after their second vaccination. Levels of SARS-CoV-2-IgG antibodies (spike and nucleocapsid protein) were qualitatively detected via chemiluminescent immunoassays (CLIAs). A previous infection with SARS-CoV-2 was an exclusion criterion. In total, 545 persons were included in this cross-sectional study. Most participants (97.8%) showed elevated anti-spike concentrations. Anti-spike levels differed significantly among vaccination schemas. Repeated vector vaccinations resulted in lower protective antibody levels. Higher age levels, immunosuppression and a longer time period since the second vaccination resulted in lower anti-spike levels. Women’s antibody levels were higher, but not significantly. Since anti-spike levels drop after vaccination, further boosters are required to increase immunoreactivity. If two vector vaccines have been administered, it is possible that an mRNA booster might increase the anti-spike level.
U2 - 10.3390/ijerph191811422
DO - 10.3390/ijerph191811422
M3 - SCORING: Journal article
C2 - 36141696
VL - 19
JO - INT J ENV RES PUB HE
JF - INT J ENV RES PUB HE
SN - 1660-4601
IS - 18
M1 - 11422
ER -
