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Coronary CT angiography derived FFR in patients with left main disease

Standard

Coronary CT angiography derived FFR in patients with left main disease. / Riedl, Katharina A; Jensen, Jesper M; Ko, Brian S; Leipsic, Jonathon; Grove, Erik Lerkevang; Mathiassen, Ole N; Bøtker, Hans Erik; Nørgaard, Bjarne L.

In: INT J CARDIOVAS IMAG, Vol. 37, No. 11, 11.2021, p. 3299-3308.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Riedl, KA, Jensen, JM, Ko, BS, Leipsic, J, Grove, EL, Mathiassen, ON, Bøtker, HE & Nørgaard, BL 2021, 'Coronary CT angiography derived FFR in patients with left main disease', INT J CARDIOVAS IMAG, vol. 37, no. 11, pp. 3299-3308. https://doi.org/10.1007/s10554-021-02371-4

APA

Riedl, K. A., Jensen, J. M., Ko, B. S., Leipsic, J., Grove, E. L., Mathiassen, O. N., Bøtker, H. E., & Nørgaard, B. L. (2021). Coronary CT angiography derived FFR in patients with left main disease. INT J CARDIOVAS IMAG, 37(11), 3299-3308. https://doi.org/10.1007/s10554-021-02371-4

Vancouver

Riedl KA, Jensen JM, Ko BS, Leipsic J, Grove EL, Mathiassen ON et al. Coronary CT angiography derived FFR in patients with left main disease. INT J CARDIOVAS IMAG. 2021 Nov;37(11):3299-3308. https://doi.org/10.1007/s10554-021-02371-4

Bibtex

@article{11ef6d01cec440479c6f9db41eb83eae,
title = "Coronary CT angiography derived FFR in patients with left main disease",
abstract = "The presence of left main coronary artery disease (LMCAD) is associated with an unfavorable clinical outcome. The clinical utility of FFRCT testing for non-invasive physiological assessment in LMCAD remains largely unknown. In this single center observational study LMCAD patients were retrospectively identified between November 2015 and December 2017. We evaluated the relationship between LMCAD diameter stenosis and downstream FFRCT values, and the clinical consequences following FFRCT testing in patients with LMCAD. The composite endpoint (all-cause death, myocardial infarction, unplanned revascularization) was determined over a median follow-up of 1.1 years. LMCAD was registered in 432 of 3202 (13%) patients having coronary CTA. FFRCT was prescribed in 213 (49%), while 59 (14%) patients were referred directly to invasive angiography or myocardial perfusion imaging. FFRCT was performed in 195 (45%) patients. LM stenosis severity was inversely related to downstream FFRCT values. In patients with simple LMCAD with stenosis ≥ 50%, > 80% had FFRCT > 0.80 in non-diseased proximal and downstream segments (n = 7). No patients with simple LMCAD and FFRCT > 0.80 (n = 20) suffered an adverse clinical outcome. FFRCT testing in patients with LMCAD is feasible. LM stenosis severity is inversely related to FFRCT value. Patients with LMCAD and FFRCT > 0.80 have favorable clinical outcomes at short-term follow-up. Large-scale studies assessing the clinical utility and safety of deferring invasive catheterization following FFRCT testing in patients with LMCAD are warranted.",
keywords = "Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease/diagnostic imaging, Coronary Stenosis/diagnostic imaging, Coronary Vessels/diagnostic imaging, Fractional Flow Reserve, Myocardial, Humans, Predictive Value of Tests, Retrospective Studies, Severity of Illness Index, Tomography, X-Ray Computed",
author = "Riedl, {Katharina A} and Jensen, {Jesper M} and Ko, {Brian S} and Jonathon Leipsic and Grove, {Erik Lerkevang} and Mathiassen, {Ole N} and B{\o}tker, {Hans Erik} and N{\o}rgaard, {Bjarne L}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = nov,
doi = "10.1007/s10554-021-02371-4",
language = "English",
volume = "37",
pages = "3299--3308",
journal = "INT J CARDIOVAS IMAG",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "11",

}

RIS

TY - JOUR

T1 - Coronary CT angiography derived FFR in patients with left main disease

AU - Riedl, Katharina A

AU - Jensen, Jesper M

AU - Ko, Brian S

AU - Leipsic, Jonathon

AU - Grove, Erik Lerkevang

AU - Mathiassen, Ole N

AU - Bøtker, Hans Erik

AU - Nørgaard, Bjarne L

N1 - © 2021. The Author(s).

PY - 2021/11

Y1 - 2021/11

N2 - The presence of left main coronary artery disease (LMCAD) is associated with an unfavorable clinical outcome. The clinical utility of FFRCT testing for non-invasive physiological assessment in LMCAD remains largely unknown. In this single center observational study LMCAD patients were retrospectively identified between November 2015 and December 2017. We evaluated the relationship between LMCAD diameter stenosis and downstream FFRCT values, and the clinical consequences following FFRCT testing in patients with LMCAD. The composite endpoint (all-cause death, myocardial infarction, unplanned revascularization) was determined over a median follow-up of 1.1 years. LMCAD was registered in 432 of 3202 (13%) patients having coronary CTA. FFRCT was prescribed in 213 (49%), while 59 (14%) patients were referred directly to invasive angiography or myocardial perfusion imaging. FFRCT was performed in 195 (45%) patients. LM stenosis severity was inversely related to downstream FFRCT values. In patients with simple LMCAD with stenosis ≥ 50%, > 80% had FFRCT > 0.80 in non-diseased proximal and downstream segments (n = 7). No patients with simple LMCAD and FFRCT > 0.80 (n = 20) suffered an adverse clinical outcome. FFRCT testing in patients with LMCAD is feasible. LM stenosis severity is inversely related to FFRCT value. Patients with LMCAD and FFRCT > 0.80 have favorable clinical outcomes at short-term follow-up. Large-scale studies assessing the clinical utility and safety of deferring invasive catheterization following FFRCT testing in patients with LMCAD are warranted.

AB - The presence of left main coronary artery disease (LMCAD) is associated with an unfavorable clinical outcome. The clinical utility of FFRCT testing for non-invasive physiological assessment in LMCAD remains largely unknown. In this single center observational study LMCAD patients were retrospectively identified between November 2015 and December 2017. We evaluated the relationship between LMCAD diameter stenosis and downstream FFRCT values, and the clinical consequences following FFRCT testing in patients with LMCAD. The composite endpoint (all-cause death, myocardial infarction, unplanned revascularization) was determined over a median follow-up of 1.1 years. LMCAD was registered in 432 of 3202 (13%) patients having coronary CTA. FFRCT was prescribed in 213 (49%), while 59 (14%) patients were referred directly to invasive angiography or myocardial perfusion imaging. FFRCT was performed in 195 (45%) patients. LM stenosis severity was inversely related to downstream FFRCT values. In patients with simple LMCAD with stenosis ≥ 50%, > 80% had FFRCT > 0.80 in non-diseased proximal and downstream segments (n = 7). No patients with simple LMCAD and FFRCT > 0.80 (n = 20) suffered an adverse clinical outcome. FFRCT testing in patients with LMCAD is feasible. LM stenosis severity is inversely related to FFRCT value. Patients with LMCAD and FFRCT > 0.80 have favorable clinical outcomes at short-term follow-up. Large-scale studies assessing the clinical utility and safety of deferring invasive catheterization following FFRCT testing in patients with LMCAD are warranted.

KW - Computed Tomography Angiography

KW - Coronary Angiography

KW - Coronary Artery Disease/diagnostic imaging

KW - Coronary Stenosis/diagnostic imaging

KW - Coronary Vessels/diagnostic imaging

KW - Fractional Flow Reserve, Myocardial

KW - Humans

KW - Predictive Value of Tests

KW - Retrospective Studies

KW - Severity of Illness Index

KW - Tomography, X-Ray Computed

U2 - 10.1007/s10554-021-02371-4

DO - 10.1007/s10554-021-02371-4

M3 - SCORING: Journal article

C2 - 34383150

VL - 37

SP - 3299

EP - 3308

JO - INT J CARDIOVAS IMAG

JF - INT J CARDIOVAS IMAG

SN - 1569-5794

IS - 11

ER -