Coronary artery anomalies. Part I: Recent insights from molecular embryology
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Coronary artery anomalies. Part I: Recent insights from molecular embryology. / von Kodolitsch, Y; Ito, W D; Franzen, O; Lund, G K; Koschyk, D H; Meinertz, T.
In: Z Kardiol, Vol. 93, No. 12, 12.2004, p. 929-937.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Coronary artery anomalies. Part I: Recent insights from molecular embryology
AU - von Kodolitsch, Y
AU - Ito, W D
AU - Franzen, O
AU - Lund, G K
AU - Koschyk, D H
AU - Meinertz, T
PY - 2004/12
Y1 - 2004/12
N2 - Congenital anomalies of the coronary arteries occur in 0.2-1.2% of the general population and may cause substantial cardiovascular morbidity and mortality. We review some of the advances that have been made both, in the understanding of the embryonic development of the coronary arteries (part I) and in the clinical diagnosis and management of their anomalies (part II). In this first part of our review we elucidate basic mechanisms of coronary vasculogenesis, angiogenesis and embryonic arteriogenesis. Moreover, we review the role of cellular progenitors such as epicardium-derived cells, cardiac neural crest cells and cells of the peripheral conduction system. Then we discuss the role of growths factors (such as FGV, HIF 1, PDGF B, TGFbeta1, VEGF, and VEGFR-2) and genes (such as FOG-2, VCAM-1, Bves, and RALDH2) at different states of coronary development. and we discuss the role of the cardiac neural crest in the concurrence of coronary anomalies with aortic root malformations. This part of the article is designed to review major determinants of coronary vascular development to provide a better understanding of the multiplicity of options and mechanisms that may give rise to coronary anomaly. To this end, we highlight results from experiments that provide insight in mechanisms of coronary malformation.
AB - Congenital anomalies of the coronary arteries occur in 0.2-1.2% of the general population and may cause substantial cardiovascular morbidity and mortality. We review some of the advances that have been made both, in the understanding of the embryonic development of the coronary arteries (part I) and in the clinical diagnosis and management of their anomalies (part II). In this first part of our review we elucidate basic mechanisms of coronary vasculogenesis, angiogenesis and embryonic arteriogenesis. Moreover, we review the role of cellular progenitors such as epicardium-derived cells, cardiac neural crest cells and cells of the peripheral conduction system. Then we discuss the role of growths factors (such as FGV, HIF 1, PDGF B, TGFbeta1, VEGF, and VEGFR-2) and genes (such as FOG-2, VCAM-1, Bves, and RALDH2) at different states of coronary development. and we discuss the role of the cardiac neural crest in the concurrence of coronary anomalies with aortic root malformations. This part of the article is designed to review major determinants of coronary vascular development to provide a better understanding of the multiplicity of options and mechanisms that may give rise to coronary anomaly. To this end, we highlight results from experiments that provide insight in mechanisms of coronary malformation.
KW - Animals
KW - Coronary Vessel Anomalies/diagnosis
KW - Coronary Vessels/embryology
KW - Endothelium, Vascular/embryology
KW - Female
KW - Gene Expression Regulation/physiology
KW - Gestational Age
KW - Growth Substances/genetics
KW - Humans
KW - Infant, Newborn
KW - Neovascularization, Physiologic/genetics
KW - Pregnancy
KW - Quail
KW - Stem Cells/physiology
U2 - 10.1007/s00392-004-0152-7
DO - 10.1007/s00392-004-0152-7
M3 - SCORING: Review article
C2 - 15599567
VL - 93
SP - 929
EP - 937
IS - 12
ER -
