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Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.

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Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. / Alpatov, Roman; Shi, Yujiang; Munguba, Gustavo C; Moghimi, Babak; Joo, Jeong-Hoon; Bungert, Jörg; Sugrue, Stephen P.

In: MOL CELL BIOL, Vol. 28, No. 5, 5, 2008, p. 1584-1595.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Alpatov, R, Shi, Y, Munguba, GC, Moghimi, B, Joo, J-H, Bungert, J & Sugrue, SP 2008, 'Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.', MOL CELL BIOL, vol. 28, no. 5, 5, pp. 1584-1595. <http://www.ncbi.nlm.nih.gov/pubmed/18086895?dopt=Citation>

APA

Alpatov, R., Shi, Y., Munguba, G. C., Moghimi, B., Joo, J-H., Bungert, J., & Sugrue, S. P. (2008). Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. MOL CELL BIOL, 28(5), 1584-1595. [5]. http://www.ncbi.nlm.nih.gov/pubmed/18086895?dopt=Citation

Vancouver

Alpatov R, Shi Y, Munguba GC, Moghimi B, Joo J-H, Bungert J et al. Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene. MOL CELL BIOL. 2008;28(5):1584-1595. 5.

Bibtex

@article{9c6ad72fd8b5426bb644886167e97a92,
title = "Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.",
abstract = "CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin. Pnn/DRS (Pnn) is a {"}nuclear speckle{"}-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP. Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter. In addition, CtBP and Pnn can differentially modulate E-cadherin mRNA splicing, with polymerase II serving as an interface in this event. Therefore, the Pnn/CtBP functional interplay represents a novel mechanism linking the corepressor CtBP and Pnn to the transcription-coupled mRNA splicing of a major tumor suppressor gene. Our findings implicate the existence of the molecular switches involved in tumorigenesis, which coordinate promoter-specific events and mRNA processing, by serving as bridging elements between the regulatory complexes both at gene promoters and within the mRNA splicing machineries.",
author = "Roman Alpatov and Yujiang Shi and Munguba, {Gustavo C} and Babak Moghimi and Jeong-Hoon Joo and J{\"o}rg Bungert and Sugrue, {Stephen P}",
year = "2008",
language = "Deutsch",
volume = "28",
pages = "1584--1595",
journal = "MOL CELL BIOL",
issn = "0270-7306",
publisher = "American Society for Microbiology",
number = "5",

}

RIS

TY - JOUR

T1 - Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.

AU - Alpatov, Roman

AU - Shi, Yujiang

AU - Munguba, Gustavo C

AU - Moghimi, Babak

AU - Joo, Jeong-Hoon

AU - Bungert, Jörg

AU - Sugrue, Stephen P

PY - 2008

Y1 - 2008

N2 - CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin. Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP. Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter. In addition, CtBP and Pnn can differentially modulate E-cadherin mRNA splicing, with polymerase II serving as an interface in this event. Therefore, the Pnn/CtBP functional interplay represents a novel mechanism linking the corepressor CtBP and Pnn to the transcription-coupled mRNA splicing of a major tumor suppressor gene. Our findings implicate the existence of the molecular switches involved in tumorigenesis, which coordinate promoter-specific events and mRNA processing, by serving as bridging elements between the regulatory complexes both at gene promoters and within the mRNA splicing machineries.

AB - CtBP is a transcriptional corepressor with tumorigenic potential that targets the promoter of the tumor suppressor gene E-cadherin. Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA processing as well as transcriptional regulation of E-cadherin via its binding to CtBP. Here, we show that CtBP can recruit Pnn to CtBP-associated complexes, resulting in Pnn-dependent chromatin remodeling at the E-cadherin promoter. In addition, CtBP and Pnn can differentially modulate E-cadherin mRNA splicing, with polymerase II serving as an interface in this event. Therefore, the Pnn/CtBP functional interplay represents a novel mechanism linking the corepressor CtBP and Pnn to the transcription-coupled mRNA splicing of a major tumor suppressor gene. Our findings implicate the existence of the molecular switches involved in tumorigenesis, which coordinate promoter-specific events and mRNA processing, by serving as bridging elements between the regulatory complexes both at gene promoters and within the mRNA splicing machineries.

M3 - SCORING: Zeitschriftenaufsatz

VL - 28

SP - 1584

EP - 1595

JO - MOL CELL BIOL

JF - MOL CELL BIOL

SN - 0270-7306

IS - 5

M1 - 5

ER -