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Copeptin improves early diagnosis of acute myocardial infarction

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Copeptin improves early diagnosis of acute myocardial infarction. / Keller, Till; Tzikas, Stergios; Zeller, Tanja; Czyz, Ewa; Lillpopp, Lars; Ojeda, Francisco M; Roth, Alexander; Bickel, Christoph; Baldus, Stephan; Sinning, Christoph R; Wild, Philipp S; Lubos, Edith; Peetz, Dirk; Kunde, Jan; Hartmann, Oliver; Bergmann, Andreas; Post, Felix; Lackner, Karl J; Genth-Zotz, Sabine; Nicaud, Viviane; Tiret, Laurence; Münzel, Thomas F; Blankenberg, Stefan.

In: J AM COLL CARDIOL, Vol. 55, No. 19, 11.05.2010, p. 2096-2106.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Keller, T, Tzikas, S, Zeller, T, Czyz, E, Lillpopp, L, Ojeda, FM, Roth, A, Bickel, C, Baldus, S, Sinning, CR, Wild, PS, Lubos, E, Peetz, D, Kunde, J, Hartmann, O, Bergmann, A, Post, F, Lackner, KJ, Genth-Zotz, S, Nicaud, V, Tiret, L, Münzel, TF & Blankenberg, S 2010, 'Copeptin improves early diagnosis of acute myocardial infarction', J AM COLL CARDIOL, vol. 55, no. 19, pp. 2096-2106. https://doi.org/10.1016/j.jacc.2010.01.029

APA

Keller, T., Tzikas, S., Zeller, T., Czyz, E., Lillpopp, L., Ojeda, F. M., Roth, A., Bickel, C., Baldus, S., Sinning, C. R., Wild, P. S., Lubos, E., Peetz, D., Kunde, J., Hartmann, O., Bergmann, A., Post, F., Lackner, K. J., Genth-Zotz, S., ... Blankenberg, S. (2010). Copeptin improves early diagnosis of acute myocardial infarction. J AM COLL CARDIOL, 55(19), 2096-2106. https://doi.org/10.1016/j.jacc.2010.01.029

Vancouver

Keller T, Tzikas S, Zeller T, Czyz E, Lillpopp L, Ojeda FM et al. Copeptin improves early diagnosis of acute myocardial infarction. J AM COLL CARDIOL. 2010 May 11;55(19):2096-2106. https://doi.org/10.1016/j.jacc.2010.01.029

Bibtex

@article{402ee7b838284bc5be57de3364377df9,
title = "Copeptin improves early diagnosis of acute myocardial infarction",
abstract = "OBJECTIVES: Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation.BACKGROUND: The aim of the current investigation is to test whether determination of copeptin, an indirect marker for arginin-vasopressin, adds diagnostic information to cardiac troponin in early evaluation of patients with suspected myocardial infarction.METHODS: Between January 2007 and July 2008, patients with suspected acute coronary syndrome were consecutively enrolled in this multicenter study. Copeptin, troponin T (TnT), myoglobin, and creatine kinase-myocardial band were determined at admission and after 3 and 6 h.RESULTS: Of 1,386 (66.4% male) enrolled patients, 299 (21.6%) had the discharge diagnosis of acute myocardial infarction, 184 (13.3%) presented with unstable angina, and in 903 (65.2%) an acute coronary syndrome could be excluded. Combined measurement of copeptin and TnT on admission improved the c-statistic from 0.84 for TnT alone to 0.93 in the overall population and from 0.77 to 0.9 in patients presenting within 3 h after chest pain onset (CPO) (p < 0.001). In this group the combination of copeptin with a conventional TnT provided a negative predictive value of 92.4%.CONCLUSIONS: In triage of chest pain patients, determination of copeptin in addition to troponin improves diagnostic performance, especially early after CPO. Combined determination of troponin and copeptin provides a remarkable negative predictive value virtually independent of CPO time and therefore aids in early and safe rule-out of myocardial infarction.",
keywords = "Adult, Aged, Angina Pectoris/blood, Biomarkers/blood, Early Diagnosis, Female, Glycopeptides/blood, Humans, Male, Middle Aged, Myocardial Infarction/blood, Myoglobin/blood, Predictive Value of Tests, Prospective Studies, Troponin I/blood, Troponin T/blood",
author = "Till Keller and Stergios Tzikas and Tanja Zeller and Ewa Czyz and Lars Lillpopp and Ojeda, {Francisco M} and Alexander Roth and Christoph Bickel and Stephan Baldus and Sinning, {Christoph R} and Wild, {Philipp S} and Edith Lubos and Dirk Peetz and Jan Kunde and Oliver Hartmann and Andreas Bergmann and Felix Post and Lackner, {Karl J} and Sabine Genth-Zotz and Viviane Nicaud and Laurence Tiret and M{\"u}nzel, {Thomas F} and Stefan Blankenberg",
note = "Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.",
year = "2010",
month = may,
day = "11",
doi = "10.1016/j.jacc.2010.01.029",
language = "English",
volume = "55",
pages = "2096--2106",
journal = "J AM COLL CARDIOL",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "19",

}

RIS

TY - JOUR

T1 - Copeptin improves early diagnosis of acute myocardial infarction

AU - Keller, Till

AU - Tzikas, Stergios

AU - Zeller, Tanja

AU - Czyz, Ewa

AU - Lillpopp, Lars

AU - Ojeda, Francisco M

AU - Roth, Alexander

AU - Bickel, Christoph

AU - Baldus, Stephan

AU - Sinning, Christoph R

AU - Wild, Philipp S

AU - Lubos, Edith

AU - Peetz, Dirk

AU - Kunde, Jan

AU - Hartmann, Oliver

AU - Bergmann, Andreas

AU - Post, Felix

AU - Lackner, Karl J

AU - Genth-Zotz, Sabine

AU - Nicaud, Viviane

AU - Tiret, Laurence

AU - Münzel, Thomas F

AU - Blankenberg, Stefan

N1 - Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

PY - 2010/5/11

Y1 - 2010/5/11

N2 - OBJECTIVES: Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation.BACKGROUND: The aim of the current investigation is to test whether determination of copeptin, an indirect marker for arginin-vasopressin, adds diagnostic information to cardiac troponin in early evaluation of patients with suspected myocardial infarction.METHODS: Between January 2007 and July 2008, patients with suspected acute coronary syndrome were consecutively enrolled in this multicenter study. Copeptin, troponin T (TnT), myoglobin, and creatine kinase-myocardial band were determined at admission and after 3 and 6 h.RESULTS: Of 1,386 (66.4% male) enrolled patients, 299 (21.6%) had the discharge diagnosis of acute myocardial infarction, 184 (13.3%) presented with unstable angina, and in 903 (65.2%) an acute coronary syndrome could be excluded. Combined measurement of copeptin and TnT on admission improved the c-statistic from 0.84 for TnT alone to 0.93 in the overall population and from 0.77 to 0.9 in patients presenting within 3 h after chest pain onset (CPO) (p < 0.001). In this group the combination of copeptin with a conventional TnT provided a negative predictive value of 92.4%.CONCLUSIONS: In triage of chest pain patients, determination of copeptin in addition to troponin improves diagnostic performance, especially early after CPO. Combined determination of troponin and copeptin provides a remarkable negative predictive value virtually independent of CPO time and therefore aids in early and safe rule-out of myocardial infarction.

AB - OBJECTIVES: Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation.BACKGROUND: The aim of the current investigation is to test whether determination of copeptin, an indirect marker for arginin-vasopressin, adds diagnostic information to cardiac troponin in early evaluation of patients with suspected myocardial infarction.METHODS: Between January 2007 and July 2008, patients with suspected acute coronary syndrome were consecutively enrolled in this multicenter study. Copeptin, troponin T (TnT), myoglobin, and creatine kinase-myocardial band were determined at admission and after 3 and 6 h.RESULTS: Of 1,386 (66.4% male) enrolled patients, 299 (21.6%) had the discharge diagnosis of acute myocardial infarction, 184 (13.3%) presented with unstable angina, and in 903 (65.2%) an acute coronary syndrome could be excluded. Combined measurement of copeptin and TnT on admission improved the c-statistic from 0.84 for TnT alone to 0.93 in the overall population and from 0.77 to 0.9 in patients presenting within 3 h after chest pain onset (CPO) (p < 0.001). In this group the combination of copeptin with a conventional TnT provided a negative predictive value of 92.4%.CONCLUSIONS: In triage of chest pain patients, determination of copeptin in addition to troponin improves diagnostic performance, especially early after CPO. Combined determination of troponin and copeptin provides a remarkable negative predictive value virtually independent of CPO time and therefore aids in early and safe rule-out of myocardial infarction.

KW - Adult

KW - Aged

KW - Angina Pectoris/blood

KW - Biomarkers/blood

KW - Early Diagnosis

KW - Female

KW - Glycopeptides/blood

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Myoglobin/blood

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Troponin I/blood

KW - Troponin T/blood

U2 - 10.1016/j.jacc.2010.01.029

DO - 10.1016/j.jacc.2010.01.029

M3 - SCORING: Journal article

C2 - 20447532

VL - 55

SP - 2096

EP - 2106

JO - J AM COLL CARDIOL

JF - J AM COLL CARDIOL

SN - 0735-1097

IS - 19

ER -