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Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?

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Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms? / Demiralay, Cüneyt; Agorastos, Agorastos; Yassouridis, Alexander; Jahn, Holger; Wiedemann, Klaus; Kellner, Michael.

In: PSYCHONEUROENDOCRINO, Vol. 76, 02.2017, p. 14-18.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Demiralay, C, Agorastos, A, Yassouridis, A, Jahn, H, Wiedemann, K & Kellner, M 2017, 'Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?', PSYCHONEUROENDOCRINO, vol. 76, pp. 14-18. https://doi.org/10.1016/j.psyneuen.2016.11.006

APA

Demiralay, C., Agorastos, A., Yassouridis, A., Jahn, H., Wiedemann, K., & Kellner, M. (2017). Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms? PSYCHONEUROENDOCRINO, 76, 14-18. https://doi.org/10.1016/j.psyneuen.2016.11.006

Vancouver

Demiralay C, Agorastos A, Yassouridis A, Jahn H, Wiedemann K, Kellner M. Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms? PSYCHONEUROENDOCRINO. 2017 Feb;76:14-18. https://doi.org/10.1016/j.psyneuen.2016.11.006

Bibtex

@article{f70134a224e84ff79b59c4ad8ba572ee,
title = "Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?",
abstract = "Intravenous cholecystokinin-tetrapeptide (CCK-4) administration reliably and dose-dependently provokes panic anxiety in man, accompanied by adrenocorticotropic hormone (ACTH) and cortisol release. Preclinical findings suggest that behavioral and endocrine effects of CCK-4 are mediated via corticotropin-releasing hormone (CRH) release. Anxiogenic stimulation of the central CCK-receptors in man was shown to increase as well vasopressin (AVP), which acts synergistically with CRH as pituitary-adrenocortical axis stimulator during stress. Copeptin (CoP), the C-terminal part of pre-pro-AVP, is released in an equimolar ratio to AVP. It is more stable in the circulation and easier to determine than AVP and it was found to closely mirror the production of AVP. So far, CoP secretion has not been characterized during panic provocation. In 30 healthy male human subjects, we repeatedly measured CoP in plasma during a panic challenge and studied its correlation to Acute Panic Inventory (API) ratings and plasma ACTH and cortisol. CoP levels correlated positively with the increase in API ratings (r=0.41, p=0.03), while ACTH or cortisol did not (r=0.08, p=0.68 and r=0.12, p=0.53, respectively). CoP levels correlated also positively with ACTH (r=0.48, p=0.009) and cortisol (r=0.48, p=0.01) concentrations throughout the CCK-4 challenge. As expected, we found a positive correlation between plasma ACTH and cortisol levels (r=0.57, p=0.001). A vasopressinergic activation during CCK-4 induced panic was demonstrated, which was correlated positively to panic symptoms and pituitary-adrenocortical release. Our findings suggest a role of CoP as a potential surrogate marker of CCK-4 panic symptoms. Further studies are needed to replicate our results and to further clarify the role of CoP as a stress-sensitive hormone in different panic paradigms as well as in panic patients.",
keywords = "Journal Article",
author = "C{\"u}neyt Demiralay and Agorastos Agorastos and Alexander Yassouridis and Holger Jahn and Klaus Wiedemann and Michael Kellner",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2017",
month = feb,
doi = "10.1016/j.psyneuen.2016.11.006",
language = "English",
volume = "76",
pages = "14--18",
journal = "PSYCHONEUROENDOCRINO",
issn = "0306-4530",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Copeptin - A potential endocrine surrogate marker of CCK-4-induced panic symptoms?

AU - Demiralay, Cüneyt

AU - Agorastos, Agorastos

AU - Yassouridis, Alexander

AU - Jahn, Holger

AU - Wiedemann, Klaus

AU - Kellner, Michael

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2017/2

Y1 - 2017/2

N2 - Intravenous cholecystokinin-tetrapeptide (CCK-4) administration reliably and dose-dependently provokes panic anxiety in man, accompanied by adrenocorticotropic hormone (ACTH) and cortisol release. Preclinical findings suggest that behavioral and endocrine effects of CCK-4 are mediated via corticotropin-releasing hormone (CRH) release. Anxiogenic stimulation of the central CCK-receptors in man was shown to increase as well vasopressin (AVP), which acts synergistically with CRH as pituitary-adrenocortical axis stimulator during stress. Copeptin (CoP), the C-terminal part of pre-pro-AVP, is released in an equimolar ratio to AVP. It is more stable in the circulation and easier to determine than AVP and it was found to closely mirror the production of AVP. So far, CoP secretion has not been characterized during panic provocation. In 30 healthy male human subjects, we repeatedly measured CoP in plasma during a panic challenge and studied its correlation to Acute Panic Inventory (API) ratings and plasma ACTH and cortisol. CoP levels correlated positively with the increase in API ratings (r=0.41, p=0.03), while ACTH or cortisol did not (r=0.08, p=0.68 and r=0.12, p=0.53, respectively). CoP levels correlated also positively with ACTH (r=0.48, p=0.009) and cortisol (r=0.48, p=0.01) concentrations throughout the CCK-4 challenge. As expected, we found a positive correlation between plasma ACTH and cortisol levels (r=0.57, p=0.001). A vasopressinergic activation during CCK-4 induced panic was demonstrated, which was correlated positively to panic symptoms and pituitary-adrenocortical release. Our findings suggest a role of CoP as a potential surrogate marker of CCK-4 panic symptoms. Further studies are needed to replicate our results and to further clarify the role of CoP as a stress-sensitive hormone in different panic paradigms as well as in panic patients.

AB - Intravenous cholecystokinin-tetrapeptide (CCK-4) administration reliably and dose-dependently provokes panic anxiety in man, accompanied by adrenocorticotropic hormone (ACTH) and cortisol release. Preclinical findings suggest that behavioral and endocrine effects of CCK-4 are mediated via corticotropin-releasing hormone (CRH) release. Anxiogenic stimulation of the central CCK-receptors in man was shown to increase as well vasopressin (AVP), which acts synergistically with CRH as pituitary-adrenocortical axis stimulator during stress. Copeptin (CoP), the C-terminal part of pre-pro-AVP, is released in an equimolar ratio to AVP. It is more stable in the circulation and easier to determine than AVP and it was found to closely mirror the production of AVP. So far, CoP secretion has not been characterized during panic provocation. In 30 healthy male human subjects, we repeatedly measured CoP in plasma during a panic challenge and studied its correlation to Acute Panic Inventory (API) ratings and plasma ACTH and cortisol. CoP levels correlated positively with the increase in API ratings (r=0.41, p=0.03), while ACTH or cortisol did not (r=0.08, p=0.68 and r=0.12, p=0.53, respectively). CoP levels correlated also positively with ACTH (r=0.48, p=0.009) and cortisol (r=0.48, p=0.01) concentrations throughout the CCK-4 challenge. As expected, we found a positive correlation between plasma ACTH and cortisol levels (r=0.57, p=0.001). A vasopressinergic activation during CCK-4 induced panic was demonstrated, which was correlated positively to panic symptoms and pituitary-adrenocortical release. Our findings suggest a role of CoP as a potential surrogate marker of CCK-4 panic symptoms. Further studies are needed to replicate our results and to further clarify the role of CoP as a stress-sensitive hormone in different panic paradigms as well as in panic patients.

KW - Journal Article

U2 - 10.1016/j.psyneuen.2016.11.006

DO - 10.1016/j.psyneuen.2016.11.006

M3 - SCORING: Journal article

C2 - 27871026

VL - 76

SP - 14

EP - 18

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

ER -