Coordination of uncoupled bimanual movements by strictly timed interhemispheric connectivity
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Coordination of uncoupled bimanual movements by strictly timed interhemispheric connectivity. / Liuzzi, Gianpiero; Hörniss, Vanessa; Zimerman, Maximo; Gerloff, Christian; Hummel, Friedhelm C.
In: J NEUROSCI, Vol. 31, No. 25, 25, 2011, p. 9111-9117.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Coordination of uncoupled bimanual movements by strictly timed interhemispheric connectivity
AU - Liuzzi, Gianpiero
AU - Hörniss, Vanessa
AU - Zimerman, Maximo
AU - Gerloff, Christian
AU - Hummel, Friedhelm C
PY - 2011
Y1 - 2011
N2 - Independent use of both hands is characteristic of human action in daily life. By nature, however, in-phase bimanual movements, for example clapping, are easier to accomplish than anti-phase movements, for example playing the piano. It is commonly agreed that interhemispheric interactions play a central role in the coordination of bimanual movements. However, the spatial, temporal, and physiological properties of the interhemispheric signals that coordinate different modes of bimanual movements are still not completely understood. More precisely, do individual interhemispheric connectivity parameters have behavioral relevance for bimanual rapid anti-phase coordination? To address this question, we measured movement-related interhemispheric interactions, i.e., inhibition and facilitation, and correlated them with the performance during bimanual coordination. We found that movement-related facilitation from right premotor to left primary motor cortex (rPMd-lM1) predicted performance in anti-phase bimanual movements. It is of note that only fast facilitation during the preparatory period of a movement was associated with success in anti-phase movements. Modulation of right to left primary motor interaction (rM1-lM1) was not related to anti-phase but predicted bimanual in-phase and unimanual behavior. These data suggest that strictly timed modulation of interhemispheric rPMd-lM1 connectivity is essential for independent high-frequency use of both hands. The rM1-lM1 results indicate that adjustment of connectivity between homologous M1 may be important for the regulation of homologous muscle synergies.
AB - Independent use of both hands is characteristic of human action in daily life. By nature, however, in-phase bimanual movements, for example clapping, are easier to accomplish than anti-phase movements, for example playing the piano. It is commonly agreed that interhemispheric interactions play a central role in the coordination of bimanual movements. However, the spatial, temporal, and physiological properties of the interhemispheric signals that coordinate different modes of bimanual movements are still not completely understood. More precisely, do individual interhemispheric connectivity parameters have behavioral relevance for bimanual rapid anti-phase coordination? To address this question, we measured movement-related interhemispheric interactions, i.e., inhibition and facilitation, and correlated them with the performance during bimanual coordination. We found that movement-related facilitation from right premotor to left primary motor cortex (rPMd-lM1) predicted performance in anti-phase bimanual movements. It is of note that only fast facilitation during the preparatory period of a movement was associated with success in anti-phase movements. Modulation of right to left primary motor interaction (rM1-lM1) was not related to anti-phase but predicted bimanual in-phase and unimanual behavior. These data suggest that strictly timed modulation of interhemispheric rPMd-lM1 connectivity is essential for independent high-frequency use of both hands. The rM1-lM1 results indicate that adjustment of connectivity between homologous M1 may be important for the regulation of homologous muscle synergies.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Evoked Potentials/physiology
KW - Psychomotor Performance/physiology
KW - Motor Cortex/physiology
KW - Movement/physiology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Evoked Potentials/physiology
KW - Psychomotor Performance/physiology
KW - Motor Cortex/physiology
KW - Movement/physiology
U2 - 10.1523/JNEUROSCI.0046-11.2011
DO - 10.1523/JNEUROSCI.0046-11.2011
M3 - SCORING: Journal article
C2 - 21697362
VL - 31
SP - 9111
EP - 9117
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 25
M1 - 25
ER -