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Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions.

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Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions. / Zöllner, Christian; Johnson, P S; Bei Wang, J; Roy, A J; Layton, K M; Min Wu, J; Surratt, C K.

In: MOL BRAIN RES, Vol. 79, No. 1-2, 1-2, 2000, p. 159-162.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zöllner, C, Johnson, PS, Bei Wang, J, Roy, AJ, Layton, KM, Min Wu, J & Surratt, CK 2000, 'Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions.', MOL BRAIN RES, vol. 79, no. 1-2, 1-2, pp. 159-162. <http://www.ncbi.nlm.nih.gov/pubmed/10925154?dopt=Citation>

APA

Zöllner, C., Johnson, P. S., Bei Wang, J., Roy, A. J., Layton, K. M., Min Wu, J., & Surratt, C. K. (2000). Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions. MOL BRAIN RES, 79(1-2), 159-162. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/10925154?dopt=Citation

Vancouver

Zöllner C, Johnson PS, Bei Wang J, Roy AJ, Layton KM, Min Wu J et al. Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions. MOL BRAIN RES. 2000;79(1-2):159-162. 1-2.

Bibtex

@article{305f7fcf05224075aaa7b349b5ec96f0,
title = "Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions.",
abstract = "Removal of a 712 base pair (bp) sequence following the coding region of a human micro opioid receptor (hmuOR) cDNA unexpectedly increased expression of the receptor protein. A series of 3'-noncoding region deletion mutants revealed that at least three discrete regions following the stop codon influenced receptor expression levels. Deletion of the 205-bp 5'-noncoding region immediately preceding the Kozak sequence doubled receptor expression relative to wild type, and simultaneous deletion of 5'- and 3'-noncoding regions increased expression several fold. The hmuOR noncoding regions may participate in a regulatory mechanism that controls the number of cell surface receptors.",
author = "Christian Z{\"o}llner and Johnson, {P S} and {Bei Wang}, J and Roy, {A J} and Layton, {K M} and {Min Wu}, J and Surratt, {C K}",
year = "2000",
language = "Deutsch",
volume = "79",
pages = "159--162",
number = "1-2",

}

RIS

TY - JOUR

T1 - Control of mu opioid receptor expression by modification of cDNA 5'- and 3'-noncoding regions.

AU - Zöllner, Christian

AU - Johnson, P S

AU - Bei Wang, J

AU - Roy, A J

AU - Layton, K M

AU - Min Wu, J

AU - Surratt, C K

PY - 2000

Y1 - 2000

N2 - Removal of a 712 base pair (bp) sequence following the coding region of a human micro opioid receptor (hmuOR) cDNA unexpectedly increased expression of the receptor protein. A series of 3'-noncoding region deletion mutants revealed that at least three discrete regions following the stop codon influenced receptor expression levels. Deletion of the 205-bp 5'-noncoding region immediately preceding the Kozak sequence doubled receptor expression relative to wild type, and simultaneous deletion of 5'- and 3'-noncoding regions increased expression several fold. The hmuOR noncoding regions may participate in a regulatory mechanism that controls the number of cell surface receptors.

AB - Removal of a 712 base pair (bp) sequence following the coding region of a human micro opioid receptor (hmuOR) cDNA unexpectedly increased expression of the receptor protein. A series of 3'-noncoding region deletion mutants revealed that at least three discrete regions following the stop codon influenced receptor expression levels. Deletion of the 205-bp 5'-noncoding region immediately preceding the Kozak sequence doubled receptor expression relative to wild type, and simultaneous deletion of 5'- and 3'-noncoding regions increased expression several fold. The hmuOR noncoding regions may participate in a regulatory mechanism that controls the number of cell surface receptors.

M3 - SCORING: Zeitschriftenaufsatz

VL - 79

SP - 159

EP - 162

IS - 1-2

M1 - 1-2

ER -