Control of cccDNA function in hepatitis B virus infection.
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Control of cccDNA function in hepatitis B virus infection. / Levrero, Massimo; Pollicino, Teresa; Petersen, Jorg; Belloni, Laura; Raimondo, Giovanni; Dandri-Petersen, Maura.
In: J HEPATOL, Vol. 51, No. 3, 3, 2009, p. 581-592.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Control of cccDNA function in hepatitis B virus infection.
AU - Levrero, Massimo
AU - Pollicino, Teresa
AU - Petersen, Jorg
AU - Belloni, Laura
AU - Raimondo, Giovanni
AU - Dandri-Petersen, Maura
PY - 2009
Y1 - 2009
N2 - The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection. Novel molecular techniques have opened new possibilities to investigate the organization and the activity of the cccDNA minichromosome in vivo, and recent advances have started to shed light on the complexity of the mechanisms controlling cccDNA function. Nuclear cccDNA accumulates in hepatocyte nuclei as a stable minichromosome organized by histone and non-histone viral and cellular proteins. Identification of the molecular mechanisms regulating cccDNA stability and its transcriptional activity at the RNA, DNA and epigenetic levels in the course of chronic hepatitis B (CH-B) infection may reveal new potential therapeutic targets for anti-HBV drugs and hence assist in the design of strategies aimed at silencing and eventually depleting the cccDNA reservoir.
AB - The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection. Novel molecular techniques have opened new possibilities to investigate the organization and the activity of the cccDNA minichromosome in vivo, and recent advances have started to shed light on the complexity of the mechanisms controlling cccDNA function. Nuclear cccDNA accumulates in hepatocyte nuclei as a stable minichromosome organized by histone and non-histone viral and cellular proteins. Identification of the molecular mechanisms regulating cccDNA stability and its transcriptional activity at the RNA, DNA and epigenetic levels in the course of chronic hepatitis B (CH-B) infection may reveal new potential therapeutic targets for anti-HBV drugs and hence assist in the design of strategies aimed at silencing and eventually depleting the cccDNA reservoir.
M3 - SCORING: Zeitschriftenaufsatz
VL - 51
SP - 581
EP - 592
JO - J HEPATOL
JF - J HEPATOL
SN - 0168-8278
IS - 3
M1 - 3
ER -
