Control of Axon Selection
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Control of Axon Selection. / Richter, Melanie; Calderon de Anda, Froylan.
General & Introductory Life Sciences. Vol. eLS. 1–7. John Wiley & Sons, 2015.Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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TY - CHAP
T1 - Control of Axon Selection
AU - Richter, Melanie
AU - Calderon de Anda, Froylan
PY - 2015/2/16
Y1 - 2015/2/16
N2 - The term polarity is used to define asymmetry. In cell biology, it refers to describe the shape of a cell, the distribution of organelles, molecules and thus the intracellular trafficking of cellular components. How this asymmetry is attained in neurons is a question that has been under scrutiny as the shape of a neuron provides valuable clues to its function: Mature neurons extend dendrites and an axon to receive, process and propagate signals. A long-standing question in neurobiology is how neurons decide where the axon would form. One possibility is that external cues determine the position of axon extension. However, it is also possible that the intracellular organisation of the neuron determines where the axon will grow. Existing data provide evidence for both mechanisms playing a role during the axon selection, either concomitantly and/or sequentially.
AB - The term polarity is used to define asymmetry. In cell biology, it refers to describe the shape of a cell, the distribution of organelles, molecules and thus the intracellular trafficking of cellular components. How this asymmetry is attained in neurons is a question that has been under scrutiny as the shape of a neuron provides valuable clues to its function: Mature neurons extend dendrites and an axon to receive, process and propagate signals. A long-standing question in neurobiology is how neurons decide where the axon would form. One possibility is that external cues determine the position of axon extension. However, it is also possible that the intracellular organisation of the neuron determines where the axon will grow. Existing data provide evidence for both mechanisms playing a role during the axon selection, either concomitantly and/or sequentially.
U2 - 10.1002/9780470015902.a0025967
DO - 10.1002/9780470015902.a0025967
M3 - SCORING: Contribution to collected editions/anthologies
VL - eLS. 1–7.
BT - General & Introductory Life Sciences
PB - John Wiley & Sons
ER -
