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Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence

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Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence. / Tinhofer, Ingeborg; Jöhrens, Korinna; Keilholz, U; Kaufmann, A M; Lehmann, A; Weichert, Wilko; Stenzinger, Albrecht; Stromberger, Carmen; Klinghammer, K; Becker, E-T; Dommerich, Steffen; Stölzel, K; Hofmann, V M; Hildebrandt, B; Moser, Patrizia L; Ervens, J; Böttcher, A; Albers, Andreas E; Stabenow, R; Reinecke, Alexander; Budach, V; Hoffmeister, Bodo; Raguse, Jan D.

In: EUR J CANCER, Vol. 51, No. 4, 03.2015, p. 514-21.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Tinhofer, I, Jöhrens, K, Keilholz, U, Kaufmann, AM, Lehmann, A, Weichert, W, Stenzinger, A, Stromberger, C, Klinghammer, K, Becker, E-T, Dommerich, S, Stölzel, K, Hofmann, VM, Hildebrandt, B, Moser, PL, Ervens, J, Böttcher, A, Albers, AE, Stabenow, R, Reinecke, A, Budach, V, Hoffmeister, B & Raguse, JD 2015, 'Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence', EUR J CANCER, vol. 51, no. 4, pp. 514-21. https://doi.org/10.1016/j.ejca.2014.12.018

APA

Tinhofer, I., Jöhrens, K., Keilholz, U., Kaufmann, A. M., Lehmann, A., Weichert, W., Stenzinger, A., Stromberger, C., Klinghammer, K., Becker, E-T., Dommerich, S., Stölzel, K., Hofmann, V. M., Hildebrandt, B., Moser, P. L., Ervens, J., Böttcher, A., Albers, A. E., Stabenow, R., ... Raguse, J. D. (2015). Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence. EUR J CANCER, 51(4), 514-21. https://doi.org/10.1016/j.ejca.2014.12.018

Vancouver

Tinhofer I, Jöhrens K, Keilholz U, Kaufmann AM, Lehmann A, Weichert W et al. Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence. EUR J CANCER. 2015 Mar;51(4):514-21. https://doi.org/10.1016/j.ejca.2014.12.018

Bibtex

@article{bcdcdb66096b497aadbdb7f675b45eb9,
title = "Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence",
abstract = "BACKGROUND: Increases in incidence of oropharyngeal squamous cell carcinoma (OPSCC) in countries with falling tobacco use have been attributed to a growing role of human papilloma virus (HPV) in the carcinogenesis. Trends of HPV prevalence in populations with persistently high portions of smokers are poorly characterised.PATIENTS AND METHODS: Registry data from East Germany were used to determine incidence trends between 1998 and 2011. Data from patients treated at the Charit{\'e} University Medicine Berlin between 2004 and 2013 (cohort 1, N=436) were used for estimation of trends in HPV prevalence, smoking and survival. HPV prevalence was prospectively confirmed in cohort 2 (N=213) comprising all primary HNSCC cases at the Charit{\'e} in 2013.RESULTS: Between 1998 and 2011 incidence of both OPSCC and non-OPSCC increased. An increase in HPV prevalence (% of HPV+ cases in 2004-2006 versus 2012-2013: 27% versus 59%, P=0.0004) accompanied by a moderate decrease in the portion of current smokers was observed in OPSCC but not in non-OPSCC. The change in disease epidemiology in OPSCC was associated with significant improvement in overall survival. Increased HPV prevalence in OPSCC (48%) compared to non-OPSCC (11%) was confirmed in cohort 2.CONCLUSIONS: Despite clear differences to the United States in terms of tobacco use, the increase in OPSCC incidence in a European population was also mainly attributed to HPV, and the HPV status significantly affected prognosis. For clinical trial design it is important to consider the large group of smokers within HPV-induced OPSCC.",
keywords = "Carcinoma, Squamous Cell, Europe, Female, Head and Neck Neoplasms, Humans, Incidence, Male, Papillomaviridae, Smoking, Journal Article, Research Support, Non-U.S. Gov't",
author = "Ingeborg Tinhofer and Korinna J{\"o}hrens and U Keilholz and Kaufmann, {A M} and A Lehmann and Wilko Weichert and Albrecht Stenzinger and Carmen Stromberger and K Klinghammer and E-T Becker and Steffen Dommerich and K St{\"o}lzel and Hofmann, {V M} and B Hildebrandt and Moser, {Patrizia L} and J Ervens and A B{\"o}ttcher and Albers, {Andreas E} and R Stabenow and Alexander Reinecke and V Budach and Bodo Hoffmeister and Raguse, {Jan D}",
note = "Copyright {\textcopyright} 2015 Elsevier Ltd. All rights reserved.",
year = "2015",
month = mar,
doi = "10.1016/j.ejca.2014.12.018",
language = "English",
volume = "51",
pages = "514--21",
journal = "EUR J CANCER",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "4",

}

RIS

TY - JOUR

T1 - Contribution of human papilloma virus to the incidence of squamous cell carcinoma of the head and neck in a European population with high smoking prevalence

AU - Tinhofer, Ingeborg

AU - Jöhrens, Korinna

AU - Keilholz, U

AU - Kaufmann, A M

AU - Lehmann, A

AU - Weichert, Wilko

AU - Stenzinger, Albrecht

AU - Stromberger, Carmen

AU - Klinghammer, K

AU - Becker, E-T

AU - Dommerich, Steffen

AU - Stölzel, K

AU - Hofmann, V M

AU - Hildebrandt, B

AU - Moser, Patrizia L

AU - Ervens, J

AU - Böttcher, A

AU - Albers, Andreas E

AU - Stabenow, R

AU - Reinecke, Alexander

AU - Budach, V

AU - Hoffmeister, Bodo

AU - Raguse, Jan D

N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.

PY - 2015/3

Y1 - 2015/3

N2 - BACKGROUND: Increases in incidence of oropharyngeal squamous cell carcinoma (OPSCC) in countries with falling tobacco use have been attributed to a growing role of human papilloma virus (HPV) in the carcinogenesis. Trends of HPV prevalence in populations with persistently high portions of smokers are poorly characterised.PATIENTS AND METHODS: Registry data from East Germany were used to determine incidence trends between 1998 and 2011. Data from patients treated at the Charité University Medicine Berlin between 2004 and 2013 (cohort 1, N=436) were used for estimation of trends in HPV prevalence, smoking and survival. HPV prevalence was prospectively confirmed in cohort 2 (N=213) comprising all primary HNSCC cases at the Charité in 2013.RESULTS: Between 1998 and 2011 incidence of both OPSCC and non-OPSCC increased. An increase in HPV prevalence (% of HPV+ cases in 2004-2006 versus 2012-2013: 27% versus 59%, P=0.0004) accompanied by a moderate decrease in the portion of current smokers was observed in OPSCC but not in non-OPSCC. The change in disease epidemiology in OPSCC was associated with significant improvement in overall survival. Increased HPV prevalence in OPSCC (48%) compared to non-OPSCC (11%) was confirmed in cohort 2.CONCLUSIONS: Despite clear differences to the United States in terms of tobacco use, the increase in OPSCC incidence in a European population was also mainly attributed to HPV, and the HPV status significantly affected prognosis. For clinical trial design it is important to consider the large group of smokers within HPV-induced OPSCC.

AB - BACKGROUND: Increases in incidence of oropharyngeal squamous cell carcinoma (OPSCC) in countries with falling tobacco use have been attributed to a growing role of human papilloma virus (HPV) in the carcinogenesis. Trends of HPV prevalence in populations with persistently high portions of smokers are poorly characterised.PATIENTS AND METHODS: Registry data from East Germany were used to determine incidence trends between 1998 and 2011. Data from patients treated at the Charité University Medicine Berlin between 2004 and 2013 (cohort 1, N=436) were used for estimation of trends in HPV prevalence, smoking and survival. HPV prevalence was prospectively confirmed in cohort 2 (N=213) comprising all primary HNSCC cases at the Charité in 2013.RESULTS: Between 1998 and 2011 incidence of both OPSCC and non-OPSCC increased. An increase in HPV prevalence (% of HPV+ cases in 2004-2006 versus 2012-2013: 27% versus 59%, P=0.0004) accompanied by a moderate decrease in the portion of current smokers was observed in OPSCC but not in non-OPSCC. The change in disease epidemiology in OPSCC was associated with significant improvement in overall survival. Increased HPV prevalence in OPSCC (48%) compared to non-OPSCC (11%) was confirmed in cohort 2.CONCLUSIONS: Despite clear differences to the United States in terms of tobacco use, the increase in OPSCC incidence in a European population was also mainly attributed to HPV, and the HPV status significantly affected prognosis. For clinical trial design it is important to consider the large group of smokers within HPV-induced OPSCC.

KW - Carcinoma, Squamous Cell

KW - Europe

KW - Female

KW - Head and Neck Neoplasms

KW - Humans

KW - Incidence

KW - Male

KW - Papillomaviridae

KW - Smoking

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ejca.2014.12.018

DO - 10.1016/j.ejca.2014.12.018

M3 - SCORING: Journal article

C2 - 25623438

VL - 51

SP - 514

EP - 521

JO - EUR J CANCER

JF - EUR J CANCER

SN - 0959-8049

IS - 4

ER -