Research ExplorerPublicationsContribution of Established Stroke Risk Factors to the Burde...

Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults

Standard

Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults. / Aigner, Annette; Grittner, Ulrike; Rolfs, Arndt; Norrving, Bo; Siegerink, Bob; Busch, Markus A.

In: STROKE, Vol. 48, No. 7, 2017, p. 1744-1751.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Aigner, A, Grittner, U, Rolfs, A, Norrving, B, Siegerink, B & Busch, MA 2017, 'Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults', STROKE, vol. 48, no. 7, pp. 1744-1751. https://doi.org/10.1161/STROKEAHA.117.016599

APA

Aigner, A., Grittner, U., Rolfs, A., Norrving, B., Siegerink, B., & Busch, M. A. (2017). Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults. STROKE, 48(7), 1744-1751. https://doi.org/10.1161/STROKEAHA.117.016599

Vancouver

Aigner A, Grittner U, Rolfs A, Norrving B, Siegerink B, Busch MA. Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults. STROKE. 2017;48(7):1744-1751. https://doi.org/10.1161/STROKEAHA.117.016599

Bibtex

@article{97e6a23594ff4d30a431bb37eee9b33f,
title = "Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults",
abstract = "BACKGROUND AND PURPOSE: As stroke in young adults is assumed to have different etiologies and risk factors than in older populations, the aim of this study was to examine the contribution of established potentially modifiable cardiovascular risk factors to the burden of stroke in young adults.METHODS: A German nationwide case-control study based on patients enrolled in the SIFAP1 study (Stroke In Young Fabry Patients) 2007 to 2010 and controls from the population-based GEDA study (German Health Update) 2009 to 2010 was performed. Cases were 2125 consecutive patients aged 18 to 55 years with acute first-ever stroke from 26 clinical stroke centers; controls (age- and sex-matched, n=8500, without previous stroke) were from a nationwide community sample. Adjusted population-attributable risks of 8 risk factors (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, smoking, heavy episodic alcohol consumption, low physical activity, and obesity) and their combinations for all stroke, ischemic stroke, and primary intracerebral hemorrhage were calculated.RESULTS: Low physical activity and hypertension were the most important risk factors, accounting for 59.7% (95% confidence interval, 56.3-63.2) and 27.1% (95% confidence interval, 23.6-30.6) of all strokes, respectively. All 8 risk factors combined explained 78.9% (95% confidence interval, 76.3-81.4) of all strokes. Population-attributable risks of all risk factors were similar for all ischemic stroke subtypes. Population-attributable risks of most risk factors were higher in older age groups and in men.CONCLUSIONS: Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.",
keywords = "Adolescent, Adult, Age Factors, Case-Control Studies, Cost of Illness, Female, Humans, Male, Middle Aged, Risk Factors, Stroke, Young Adult, Clinical Trial, Journal Article, Multicenter Study, Observational Study",
author = "Annette Aigner and Ulrike Grittner and Arndt Rolfs and Bo Norrving and Bob Siegerink and Busch, {Markus A}",
note = "{\textcopyright} 2017 American Heart Association, Inc.",
year = "2017",
doi = "10.1161/STROKEAHA.117.016599",
language = "English",
volume = "48",
pages = "1744--1751",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

RIS

TY - JOUR

T1 - Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults

AU - Aigner, Annette

AU - Grittner, Ulrike

AU - Rolfs, Arndt

AU - Norrving, Bo

AU - Siegerink, Bob

AU - Busch, Markus A

N1 - © 2017 American Heart Association, Inc.

PY - 2017

Y1 - 2017

N2 - BACKGROUND AND PURPOSE: As stroke in young adults is assumed to have different etiologies and risk factors than in older populations, the aim of this study was to examine the contribution of established potentially modifiable cardiovascular risk factors to the burden of stroke in young adults.METHODS: A German nationwide case-control study based on patients enrolled in the SIFAP1 study (Stroke In Young Fabry Patients) 2007 to 2010 and controls from the population-based GEDA study (German Health Update) 2009 to 2010 was performed. Cases were 2125 consecutive patients aged 18 to 55 years with acute first-ever stroke from 26 clinical stroke centers; controls (age- and sex-matched, n=8500, without previous stroke) were from a nationwide community sample. Adjusted population-attributable risks of 8 risk factors (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, smoking, heavy episodic alcohol consumption, low physical activity, and obesity) and their combinations for all stroke, ischemic stroke, and primary intracerebral hemorrhage were calculated.RESULTS: Low physical activity and hypertension were the most important risk factors, accounting for 59.7% (95% confidence interval, 56.3-63.2) and 27.1% (95% confidence interval, 23.6-30.6) of all strokes, respectively. All 8 risk factors combined explained 78.9% (95% confidence interval, 76.3-81.4) of all strokes. Population-attributable risks of all risk factors were similar for all ischemic stroke subtypes. Population-attributable risks of most risk factors were higher in older age groups and in men.CONCLUSIONS: Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.

AB - BACKGROUND AND PURPOSE: As stroke in young adults is assumed to have different etiologies and risk factors than in older populations, the aim of this study was to examine the contribution of established potentially modifiable cardiovascular risk factors to the burden of stroke in young adults.METHODS: A German nationwide case-control study based on patients enrolled in the SIFAP1 study (Stroke In Young Fabry Patients) 2007 to 2010 and controls from the population-based GEDA study (German Health Update) 2009 to 2010 was performed. Cases were 2125 consecutive patients aged 18 to 55 years with acute first-ever stroke from 26 clinical stroke centers; controls (age- and sex-matched, n=8500, without previous stroke) were from a nationwide community sample. Adjusted population-attributable risks of 8 risk factors (hypertension, hyperlipidemia, diabetes mellitus, coronary heart disease, smoking, heavy episodic alcohol consumption, low physical activity, and obesity) and their combinations for all stroke, ischemic stroke, and primary intracerebral hemorrhage were calculated.RESULTS: Low physical activity and hypertension were the most important risk factors, accounting for 59.7% (95% confidence interval, 56.3-63.2) and 27.1% (95% confidence interval, 23.6-30.6) of all strokes, respectively. All 8 risk factors combined explained 78.9% (95% confidence interval, 76.3-81.4) of all strokes. Population-attributable risks of all risk factors were similar for all ischemic stroke subtypes. Population-attributable risks of most risk factors were higher in older age groups and in men.CONCLUSIONS: Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Case-Control Studies

KW - Cost of Illness

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Stroke

KW - Young Adult

KW - Clinical Trial

KW - Journal Article

KW - Multicenter Study

KW - Observational Study

U2 - 10.1161/STROKEAHA.117.016599

DO - 10.1161/STROKEAHA.117.016599

M3 - SCORING: Journal article

C2 - 28619986

VL - 48

SP - 1744

EP - 1751

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 7

ER -