Contrasting association of a non-synonymous leptin receptor gene polymorphism with Wegener's granulomatosis and Churg-Strauss syndrome.

  • Stefan Wieczorek
  • Julia U Holle
  • Jan P Bremer
  • Dennis Wibisono
  • Frank Moosig
  • Harald Fricke
  • Gunter Assmann
  • Lorraine Harper
  • Larissa Arning
  • Wolfgang L Gross
  • Joerg T Epplen

Abstract

There is evidence that the leptin/ghrelin system is involved in T-cell regulation and plays a role in (auto)immune disorders such as SLE, RA and ANCA-associated vasculitides (AAVs). Here, we evaluate the genetic background of this system in WG.

Bibliographical data

Original languageGerman
Article number5
ISSN1462-0324
Publication statusPublished - 2010
pubmed 20185531