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Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging.

Standard

Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging. / Korkusuz, Huedayi; Ulbrich, Karsten; Bihrer, Verena; Welzel, Katerina; Chernikov, Valery; Knobloch, Thomas; Petersen, Sabine; Huebner, Frank; Ackermann, Hanns; Gelperina, Svetlana; Korkusuz, Yuecel; Kromen, Wolfgang; Hammerstingl, Renate; Haupenthal, Jörg; Fiehler, Jens; Zeuzem, Stefan; Kreuter, Jörg; Vogl, Thomas J; Piiper, Albrecht.

In: MOL IMAGING, Vol. 11, No. 4, 4, 2012, p. 272-279.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Korkusuz, H, Ulbrich, K, Bihrer, V, Welzel, K, Chernikov, V, Knobloch, T, Petersen, S, Huebner, F, Ackermann, H, Gelperina, S, Korkusuz, Y, Kromen, W, Hammerstingl, R, Haupenthal, J, Fiehler, J, Zeuzem, S, Kreuter, J, Vogl, TJ & Piiper, A 2012, 'Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging.', MOL IMAGING, vol. 11, no. 4, 4, pp. 272-279.

APA

Korkusuz, H., Ulbrich, K., Bihrer, V., Welzel, K., Chernikov, V., Knobloch, T., Petersen, S., Huebner, F., Ackermann, H., Gelperina, S., Korkusuz, Y., Kromen, W., Hammerstingl, R., Haupenthal, J., Fiehler, J., Zeuzem, S., Kreuter, J., Vogl, T. J., & Piiper, A. (2012). Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging. MOL IMAGING, 11(4), 272-279. [4].

Vancouver

Korkusuz H, Ulbrich K, Bihrer V, Welzel K, Chernikov V, Knobloch T et al. Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging. MOL IMAGING. 2012;11(4):272-279. 4.

Bibtex

@article{6e426162c67b4b06b37dc5460b15536d,
title = "Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging.",
abstract = "Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor-expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain (p ?=? .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver (p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP (p ?=? .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.",
author = "Huedayi Korkusuz and Karsten Ulbrich and Verena Bihrer and Katerina Welzel and Valery Chernikov and Thomas Knobloch and Sabine Petersen and Frank Huebner and Hanns Ackermann and Svetlana Gelperina and Yuecel Korkusuz and Wolfgang Kromen and Renate Hammerstingl and J{\"o}rg Haupenthal and Jens Fiehler and Stefan Zeuzem and J{\"o}rg Kreuter and Vogl, {Thomas J} and Albrecht Piiper",
year = "2012",
language = "English",
volume = "11",
pages = "272--279",
journal = "MOL IMAGING",
issn = "1535-3508",
publisher = "Decker Publishing",
number = "4",

}

RIS

TY - JOUR

T1 - Contrast enhancement of the brain by folate-conjugated gadolinium-diethylenetriaminepentaacetic acid-human serum albumin nanoparticles by magnetic resonance imaging.

AU - Korkusuz, Huedayi

AU - Ulbrich, Karsten

AU - Bihrer, Verena

AU - Welzel, Katerina

AU - Chernikov, Valery

AU - Knobloch, Thomas

AU - Petersen, Sabine

AU - Huebner, Frank

AU - Ackermann, Hanns

AU - Gelperina, Svetlana

AU - Korkusuz, Yuecel

AU - Kromen, Wolfgang

AU - Hammerstingl, Renate

AU - Haupenthal, Jörg

AU - Fiehler, Jens

AU - Zeuzem, Stefan

AU - Kreuter, Jörg

AU - Vogl, Thomas J

AU - Piiper, Albrecht

PY - 2012

Y1 - 2012

N2 - Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor-expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain (p ?=? .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver (p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP (p ?=? .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.

AB - Different from regular small molecule contrast agents, nanoparticle-based contrast agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared from human serum albumin (HSA), loaded with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), and coated with folic acid (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases the affinity of the Gd-HSA-NP to FA receptor-expressing cells. Clinical 3 T MRI was used to evaluate the signal intensities in the different organs of mice injected with Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-FA. Signal intensities were measured and standardized by calculating the signal to noise ratios. In general, the NP-based contrast agents provided stronger contrasting than Gd-DTPA. Gd-HSA-NP-FA provided a significant contrast enhancement (CE) in the brain (p ?=? .0032), whereas Gd-DTPA or Gd-HSA-NP did not. All studied MRI contrast agents showed significant CE in the blood, kidney, and liver (p < .05). Gd-HSA-NP-FA elicited significantly higher CE in the blood than Gd-HSA-NP (p ?=? .0069); Gd-HSA-NP and Gd-HSA-NP-FA did not show CE in skeletal muscle and gallbladder; Gd-HSA-NP, but not Gd-HSA-NP-FA, showed CE in the cardiac muscle. Gd-HSA-NP-FA has potential as an MRI contrast agent in the brain.

M3 - SCORING: Journal article

VL - 11

SP - 272

EP - 279

JO - MOL IMAGING

JF - MOL IMAGING

SN - 1535-3508

IS - 4

M1 - 4

ER -