Contractility of the epididymal duct: function, regulation and potential drug effects

V Elfgen; A Mietens; M Mewe; T Hau; R Middendorff

doi:10.1530/REP-17-0754

Contractility of the epididymal duct: function, regulation and potential drug effects

Standard

Contractility of the epididymal duct: function, regulation and potential drug effects. / Elfgen, V; Mietens, A; Mewe, M; Hau, T; Middendorff, R.

In: REPRODUCTION, Vol. 156, No. 4, 01.10.2018, p. R125–R141.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Elfgen, V, Mietens, A, Mewe, M, Hau, T & Middendorff, R 2018, 'Contractility of the epididymal duct: function, regulation and potential drug effects', REPRODUCTION, vol. 156, no. 4, pp. R125–R141. https://doi.org/10.1530/REP-17-0754

APA

Elfgen, V., Mietens, A., Mewe, M., Hau, T., & Middendorff, R. (2018). Contractility of the epididymal duct: function, regulation and potential drug effects. REPRODUCTION, 156(4), R125–R141. https://doi.org/10.1530/REP-17-0754

Vancouver

Elfgen V, Mietens A, Mewe M, Hau T, Middendorff R. Contractility of the epididymal duct: function, regulation and potential drug effects. REPRODUCTION. 2018 Oct 1;156(4):R125–R141. https://doi.org/10.1530/REP-17-0754

Bibtex

@article{8765a4b462c643c7b070552b37c68d8b,

title = "Contractility of the epididymal duct: function, regulation and potential drug effects",

abstract = "During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review, we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.",

keywords = "Journal Article, Research Support, Non-U.S. Gov't",

author = "V Elfgen and A Mietens and M Mewe and T Hau and R Middendorff",

note = "2018 Society for Reproduction and Fertility",

year = "2018",

month = oct,

day = "1",

doi = "10.1530/REP-17-0754",

language = "English",

volume = "156",

pages = "R125–R141",

journal = "REPRODUCTION",

issn = "1470-1626",

publisher = "BioScientifica Ltd.",

number = "4",

}

RIS

TY - JOUR

T1 - Contractility of the epididymal duct: function, regulation and potential drug effects

AU - Elfgen, V

AU - Mietens, A

AU - Mewe, M

AU - Hau, T

AU - Middendorff, R

N1 - 2018 Society for Reproduction and Fertility

PY - 2018/10/1

Y1 - 2018/10/1

N2 - During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review, we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.

AB - During their transit through the epididymis, spermatozoa mature and acquire motility and fertilizing capacity. The smooth muscle cells (SMCs) of the epididymal duct are thought to be responsible for the adequate transport of spermatozoa. Thus, precise regulation of SMC function also represents a prerequisite for sperm maturation thereby contributing to male fertility. In this review, we would like to highlight various aspects of epididymal SMC function and discuss several angles with respect to regulation of contraction and relaxation. Different to the vas deferens, where disturbed SMC pathways resulting in male infertility could be defined, comparable information is missing in the epididymis. We therefore include some vas deferens data which could also be useful for a better understanding of epididymal SMC function. Furthermore, we would like to draw attention to drugs used in clinical practice and their potential (side) effects on contractions in the epididymis.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1530/REP-17-0754

DO - 10.1530/REP-17-0754

M3 - SCORING: Review article

C2 - 30304934

VL - 156

SP - R125–R141

JO - REPRODUCTION

JF - REPRODUCTION

SN - 1470-1626

IS - 4

ER -