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Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.

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Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. / Raedt, Thomas De; Stephens, Matthew; Heyns, Ine; Brems, Hilde; Thijs, Daisy; Messiaen, Ludwine; Stephens, Karen; Lazaro, Conxi; Wimmer, Katharina; Kehrer-Sawatzki, Hildegard; Vidaud, Dominique; Kluwe, Lan; Marynen, Peter; Legius, Eric.

In: NAT GENET, Vol. 38, No. 12, 12, 2006, p. 1419-1423.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Raedt, TD, Stephens, M, Heyns, I, Brems, H, Thijs, D, Messiaen, L, Stephens, K, Lazaro, C, Wimmer, K, Kehrer-Sawatzki, H, Vidaud, D, Kluwe, L, Marynen, P & Legius, E 2006, 'Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.', NAT GENET, vol. 38, no. 12, 12, pp. 1419-1423. <http://www.ncbi.nlm.nih.gov/pubmed/17115058?dopt=Citation>

APA

Raedt, T. D., Stephens, M., Heyns, I., Brems, H., Thijs, D., Messiaen, L., Stephens, K., Lazaro, C., Wimmer, K., Kehrer-Sawatzki, H., Vidaud, D., Kluwe, L., Marynen, P., & Legius, E. (2006). Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. NAT GENET, 38(12), 1419-1423. [12]. http://www.ncbi.nlm.nih.gov/pubmed/17115058?dopt=Citation

Vancouver

Raedt TD, Stephens M, Heyns I, Brems H, Thijs D, Messiaen L et al. Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion. NAT GENET. 2006;38(12):1419-1423. 12.

Bibtex

@article{95e7a19dd91b43c283f580235319e885,
title = "Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.",
abstract = "Several large-scale studies of human genetic variation have provided insights into processes such as recombination that have shaped human diversity. However, regions such as low-copy repeats (LCRs) have proven difficult to characterize, hindering efforts to understand the processes operating in these regions. We present a detailed study of genetic variation and underlying recombination processes in two copies of an LCR (NF1REPa and NF1REPc) on chromosome 17 involved in the generation of NF1 microdeletions and in a third copy (REP19) on chromosome 19 from which the others originated over 6.7 million years ago. We find evidence for shared hotspots of recombination among the LCRs. REP19 seems to contain hotspots in the same place as the nonallelic recombination hotspots in NF1REPa and NF1REPc. This apparent conservation of patterns of recombination hotspots in moderately diverged paralogous regions contrasts with recent evidence that these patterns are not conserved in less-diverged orthologous regions of chimpanzees.",
author = "Raedt, {Thomas De} and Matthew Stephens and Ine Heyns and Hilde Brems and Daisy Thijs and Ludwine Messiaen and Karen Stephens and Conxi Lazaro and Katharina Wimmer and Hildegard Kehrer-Sawatzki and Dominique Vidaud and Lan Kluwe and Peter Marynen and Eric Legius",
year = "2006",
language = "Deutsch",
volume = "38",
pages = "1419--1423",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.

AU - Raedt, Thomas De

AU - Stephens, Matthew

AU - Heyns, Ine

AU - Brems, Hilde

AU - Thijs, Daisy

AU - Messiaen, Ludwine

AU - Stephens, Karen

AU - Lazaro, Conxi

AU - Wimmer, Katharina

AU - Kehrer-Sawatzki, Hildegard

AU - Vidaud, Dominique

AU - Kluwe, Lan

AU - Marynen, Peter

AU - Legius, Eric

PY - 2006

Y1 - 2006

N2 - Several large-scale studies of human genetic variation have provided insights into processes such as recombination that have shaped human diversity. However, regions such as low-copy repeats (LCRs) have proven difficult to characterize, hindering efforts to understand the processes operating in these regions. We present a detailed study of genetic variation and underlying recombination processes in two copies of an LCR (NF1REPa and NF1REPc) on chromosome 17 involved in the generation of NF1 microdeletions and in a third copy (REP19) on chromosome 19 from which the others originated over 6.7 million years ago. We find evidence for shared hotspots of recombination among the LCRs. REP19 seems to contain hotspots in the same place as the nonallelic recombination hotspots in NF1REPa and NF1REPc. This apparent conservation of patterns of recombination hotspots in moderately diverged paralogous regions contrasts with recent evidence that these patterns are not conserved in less-diverged orthologous regions of chimpanzees.

AB - Several large-scale studies of human genetic variation have provided insights into processes such as recombination that have shaped human diversity. However, regions such as low-copy repeats (LCRs) have proven difficult to characterize, hindering efforts to understand the processes operating in these regions. We present a detailed study of genetic variation and underlying recombination processes in two copies of an LCR (NF1REPa and NF1REPc) on chromosome 17 involved in the generation of NF1 microdeletions and in a third copy (REP19) on chromosome 19 from which the others originated over 6.7 million years ago. We find evidence for shared hotspots of recombination among the LCRs. REP19 seems to contain hotspots in the same place as the nonallelic recombination hotspots in NF1REPa and NF1REPc. This apparent conservation of patterns of recombination hotspots in moderately diverged paralogous regions contrasts with recent evidence that these patterns are not conserved in less-diverged orthologous regions of chimpanzees.

M3 - SCORING: Zeitschriftenaufsatz

VL - 38

SP - 1419

EP - 1423

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 12

M1 - 12

ER -