Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy.
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Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy. / Sun, Maxine; Abdollah, Firas; Bianchi, Marco; Trinh, Quoc-Dien; Shariat, Shahrokh F; Jeldres, Claudio; Tian, Zhe; Hansen, Jens; Briganti, Alberto; Graefen, Markus; Montorsi, Francesco; Perrotte, Paul; Karakiewicz, Pierre I.
In: EUR J CANCER, Vol. 48(10), 2012, p. 1503-1511.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Conditional survival of patients with urothelial carcinoma of the urinary bladder treated with radical cystectomy.
AU - Sun, Maxine
AU - Abdollah, Firas
AU - Bianchi, Marco
AU - Trinh, Quoc-Dien
AU - Shariat, Shahrokh F
AU - Jeldres, Claudio
AU - Tian, Zhe
AU - Hansen, Jens
AU - Briganti, Alberto
AU - Graefen, Markus
AU - Montorsi, Francesco
AU - Perrotte, Paul
AU - Karakiewicz, Pierre I
PY - 2012
Y1 - 2012
N2 - AIM OF STUDY: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). METHODS: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. RESULTS: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ?1, 2, 3, 4 and 5years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. CONCLUSION: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
AB - AIM OF STUDY: To examine the impact of survival probability according to duration of survivorship following radical cystectomy (RC) in patients diagnosed with urothelial carcinoma of the urinary bladder (UCUB). METHODS: Overall, 4991 UCUB patients who underwent RC were abstracted. The cumulative survival estimates were used to generate conditional survival rates. Cox regression analyses were performed for prediction of cancer-specific mortality (CSM), according to duration of survivorship. RESULTS: The five-year CSM-free survival rate was 63.9% at RC, and increased to 71.0%, 77.5%, 81.7%, 85.9% and 86.3% in patients who survived ?1, 2, 3, 4 and 5years, respectively. Patients with pT2-4 disease benefitted from the highest increase in survivorship two years after RC. The same findings were recorded according to patients' nodal status. CONCLUSION: The survival of the first two years after RC markedly improves individual patient prognosis. The prognostic gains differ according to patient and tumour characteristics.
M3 - SCORING: Journal article
VL - 48(10)
SP - 1503
EP - 1511
JO - EUR J CANCER
JF - EUR J CANCER
SN - 0959-8049
ER -