Conditional survival after nephrectomy for renal cell carcinoma (RCC): changes in future survival probability over time.
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Conditional survival after nephrectomy for renal cell carcinoma (RCC): changes in future survival probability over time. / Bianchi, Marco; Becker, Andreas; Hansen, Jens; Trinh, Quoc-Dien; Tian, Zhe; Abdollah, Firas; Briganti, Alberto; Shariat, Shahrokh F; Perrotte, Paul; Montorsi, Francesco; Karakiewicz, Pierre I; Sun, Maxine.
In: BJU INT, Vol. 111, No. 8, 8, 2013, p. 283-289.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Conditional survival after nephrectomy for renal cell carcinoma (RCC): changes in future survival probability over time.
AU - Bianchi, Marco
AU - Becker, Andreas
AU - Hansen, Jens
AU - Trinh, Quoc-Dien
AU - Tian, Zhe
AU - Abdollah, Firas
AU - Briganti, Alberto
AU - Shariat, Shahrokh F
AU - Perrotte, Paul
AU - Montorsi, Francesco
AU - Karakiewicz, Pierre I
AU - Sun, Maxine
N1 - © 2013 BJU International.
PY - 2013
Y1 - 2013
N2 - OBJECTIVE: To examine the impact of length of survival on future survival probability, otherwise known as the effect of conditional survival (CS), after nephrectomy (NT) in patients diagnosed with renal cell carcinoma (RCC).PATIENTS AND METHODS: Overall, 42,090 patients with RCC who underwent NT were abstracted from the Surveillance, Epidemiology, and End Results database (1988-2008). Based on cumulative survival estimates, CS rates were derived according to patient and disease characteristics. Separate multivariable Cox regression analyses were performed for the prediction of cancer-specific mortality (CSM), according to 1-, 2-, 3-, 4- and 5-year survival postoperatively.RESULTS: Immediately after surgery, the 5-year cancer-specific survival rate was 83.5%. Amongst patients who survived ≥1, ≥2, ≥3, ≥4, and ≥5 years after NT, the probability rates for surviving an additional 5 years were 87.0, 89.6, 90.9, 92.0 and 92.3%, respectively. Provided that patients survived 1 and 2 years after NT, the probability of being CSM-free for another 5 years increased by +4.1 and 4.3% for stage III and +12.9 and 10.3% for stage IV disease, respectively. Similar observations were recorded for patient age, grade, nodal stage and tumour size, and were confirmed upon multivariable analyses.CONCLUSION: Survival probabilities vary according to length of survival after NT. Specifically, even amongst patients with more advanced disease at surgery, a more favourable prognosis can be achieved after surviving for 1-2 years.
AB - OBJECTIVE: To examine the impact of length of survival on future survival probability, otherwise known as the effect of conditional survival (CS), after nephrectomy (NT) in patients diagnosed with renal cell carcinoma (RCC).PATIENTS AND METHODS: Overall, 42,090 patients with RCC who underwent NT were abstracted from the Surveillance, Epidemiology, and End Results database (1988-2008). Based on cumulative survival estimates, CS rates were derived according to patient and disease characteristics. Separate multivariable Cox regression analyses were performed for the prediction of cancer-specific mortality (CSM), according to 1-, 2-, 3-, 4- and 5-year survival postoperatively.RESULTS: Immediately after surgery, the 5-year cancer-specific survival rate was 83.5%. Amongst patients who survived ≥1, ≥2, ≥3, ≥4, and ≥5 years after NT, the probability rates for surviving an additional 5 years were 87.0, 89.6, 90.9, 92.0 and 92.3%, respectively. Provided that patients survived 1 and 2 years after NT, the probability of being CSM-free for another 5 years increased by +4.1 and 4.3% for stage III and +12.9 and 10.3% for stage IV disease, respectively. Similar observations were recorded for patient age, grade, nodal stage and tumour size, and were confirmed upon multivariable analyses.CONCLUSION: Survival probabilities vary according to length of survival after NT. Specifically, even amongst patients with more advanced disease at surgery, a more favourable prognosis can be achieved after surviving for 1-2 years.
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Renal Cell
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Kidney Neoplasms
KW - Male
KW - Middle Aged
KW - Neoplasm Staging
KW - Nephrectomy
KW - Postoperative Period
KW - Probability
KW - Prognosis
KW - Retrospective Studies
KW - SEER Program
KW - Survival Rate
KW - United States
U2 - 10.1111/bju.12115
DO - 10.1111/bju.12115
M3 - SCORING: Journal article
C2 - 23714646
VL - 111
SP - 283
EP - 289
JO - BJU INT
JF - BJU INT
SN - 1464-4096
IS - 8
M1 - 8
ER -
