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Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve

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Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve. / Kim, Ung; Blanke, Philipp; Windecker, Stephan; Kasel, Albert M; Schäfer, Ulrich; Walters, Darren; Linke, Axel; Le Breton, Herve; Schymik, Gerhard; Spence, Mark S; Søndergaard, Lars; Abdel-Wahab, Mohammed; Worthley, Stephen; Tchétché, Didier; Reichenspurner, Hermann; Ohana, Mickael; Sellers, Stephanie L; Leipsic, Jonathon A.

In: EUROINTERVENTION, Vol. 14, No. 5, 03.08.2018, p. e511-e518.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kim, U, Blanke, P, Windecker, S, Kasel, AM, Schäfer, U, Walters, D, Linke, A, Le Breton, H, Schymik, G, Spence, MS, Søndergaard, L, Abdel-Wahab, M, Worthley, S, Tchétché, D, Reichenspurner, H, Ohana, M, Sellers, SL & Leipsic, JA 2018, 'Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve', EUROINTERVENTION, vol. 14, no. 5, pp. e511-e518. https://doi.org/10.4244/EIJ-D-17-01040

APA

Kim, U., Blanke, P., Windecker, S., Kasel, A. M., Schäfer, U., Walters, D., Linke, A., Le Breton, H., Schymik, G., Spence, M. S., Søndergaard, L., Abdel-Wahab, M., Worthley, S., Tchétché, D., Reichenspurner, H., Ohana, M., Sellers, S. L., & Leipsic, J. A. (2018). Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve. EUROINTERVENTION, 14(5), e511-e518. https://doi.org/10.4244/EIJ-D-17-01040

Vancouver

Kim U, Blanke P, Windecker S, Kasel AM, Schäfer U, Walters D et al. Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve. EUROINTERVENTION. 2018 Aug 3;14(5):e511-e518. https://doi.org/10.4244/EIJ-D-17-01040

Bibtex

@article{57888e2281164e9fba6ad307a91c2ee7,
title = "Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve",
abstract = "AIMS: We aimed to evaluate the relationship between CT-based annular perimeter oversizing and the incidence of paravalvular aortic regurgitation (PAR) and permanent pacemaker (PPM) implantation in patients treated with the new self-expanding CENTERA transcatheter heart valve (THV) for severe aortic stenosis.METHODS AND RESULTS: One hundred and ninety-eight patients in the CENTERA-EU trial were stratified a priori into four groups based on the perimeter oversizing (2.5-10%, 10-15%, 15-20% and >20%). PAR at 30 days was moderate or higher in 0.6% of patients. The frequency of PPM implantation was 4.9%. The mean perimeter oversizing was 16.2±5.6%. For patients with a perimeter oversizing >10%, an inverse relationship between oversizing and ≥mild PAR was observed (43.3% for 10-15% oversizing; 37.7%, 15-20%; 33.3%, >20%). No association between oversizing and effective orifice area was observed. The optimal cut-off value of perimeter oversizing for the prediction of ≥mild PAR was 15.9% (AUC 0.718, 95% CI: 0.576, 0.860). No annular ruptures were observed.CONCLUSIONS: The CENTERA THV appears to have a wide range of sizing tolerance. The degree of oversizing to mitigate PAR is relatively low compared to other self-expanding transcatheter devices. There appears to be no compromise between occurrence of PAR and PPM across this wide range of oversizing.",
keywords = "Aortic Valve, Aortic Valve Insufficiency/epidemiology, Aortic Valve Stenosis, Heart Valve Prosthesis, Humans, Incidence, Pacemaker, Artificial, Predictive Value of Tests, Prosthesis Design, Severity of Illness Index, Transcatheter Aortic Valve Replacement, Treatment Outcome",
author = "Ung Kim and Philipp Blanke and Stephan Windecker and Kasel, {Albert M} and Ulrich Sch{\"a}fer and Darren Walters and Axel Linke and {Le Breton}, Herve and Gerhard Schymik and Spence, {Mark S} and Lars S{\o}ndergaard and Mohammed Abdel-Wahab and Stephen Worthley and Didier Tch{\'e}tch{\'e} and Hermann Reichenspurner and Mickael Ohana and Sellers, {Stephanie L} and Leipsic, {Jonathon A}",
year = "2018",
month = aug,
day = "3",
doi = "10.4244/EIJ-D-17-01040",
language = "English",
volume = "14",
pages = "e511--e518",
journal = "EUROINTERVENTION",
issn = "1774-024X",
publisher = "EUROPA EDITION",
number = "5",

}

RIS

TY - JOUR

T1 - Computed tomography-based oversizing and incidence of paravalvular aortic regurgitation and permanent pacemaker implantation with a new-generation self-expanding transcatheter heart valve

AU - Kim, Ung

AU - Blanke, Philipp

AU - Windecker, Stephan

AU - Kasel, Albert M

AU - Schäfer, Ulrich

AU - Walters, Darren

AU - Linke, Axel

AU - Le Breton, Herve

AU - Schymik, Gerhard

AU - Spence, Mark S

AU - Søndergaard, Lars

AU - Abdel-Wahab, Mohammed

AU - Worthley, Stephen

AU - Tchétché, Didier

AU - Reichenspurner, Hermann

AU - Ohana, Mickael

AU - Sellers, Stephanie L

AU - Leipsic, Jonathon A

PY - 2018/8/3

Y1 - 2018/8/3

N2 - AIMS: We aimed to evaluate the relationship between CT-based annular perimeter oversizing and the incidence of paravalvular aortic regurgitation (PAR) and permanent pacemaker (PPM) implantation in patients treated with the new self-expanding CENTERA transcatheter heart valve (THV) for severe aortic stenosis.METHODS AND RESULTS: One hundred and ninety-eight patients in the CENTERA-EU trial were stratified a priori into four groups based on the perimeter oversizing (2.5-10%, 10-15%, 15-20% and >20%). PAR at 30 days was moderate or higher in 0.6% of patients. The frequency of PPM implantation was 4.9%. The mean perimeter oversizing was 16.2±5.6%. For patients with a perimeter oversizing >10%, an inverse relationship between oversizing and ≥mild PAR was observed (43.3% for 10-15% oversizing; 37.7%, 15-20%; 33.3%, >20%). No association between oversizing and effective orifice area was observed. The optimal cut-off value of perimeter oversizing for the prediction of ≥mild PAR was 15.9% (AUC 0.718, 95% CI: 0.576, 0.860). No annular ruptures were observed.CONCLUSIONS: The CENTERA THV appears to have a wide range of sizing tolerance. The degree of oversizing to mitigate PAR is relatively low compared to other self-expanding transcatheter devices. There appears to be no compromise between occurrence of PAR and PPM across this wide range of oversizing.

AB - AIMS: We aimed to evaluate the relationship between CT-based annular perimeter oversizing and the incidence of paravalvular aortic regurgitation (PAR) and permanent pacemaker (PPM) implantation in patients treated with the new self-expanding CENTERA transcatheter heart valve (THV) for severe aortic stenosis.METHODS AND RESULTS: One hundred and ninety-eight patients in the CENTERA-EU trial were stratified a priori into four groups based on the perimeter oversizing (2.5-10%, 10-15%, 15-20% and >20%). PAR at 30 days was moderate or higher in 0.6% of patients. The frequency of PPM implantation was 4.9%. The mean perimeter oversizing was 16.2±5.6%. For patients with a perimeter oversizing >10%, an inverse relationship between oversizing and ≥mild PAR was observed (43.3% for 10-15% oversizing; 37.7%, 15-20%; 33.3%, >20%). No association between oversizing and effective orifice area was observed. The optimal cut-off value of perimeter oversizing for the prediction of ≥mild PAR was 15.9% (AUC 0.718, 95% CI: 0.576, 0.860). No annular ruptures were observed.CONCLUSIONS: The CENTERA THV appears to have a wide range of sizing tolerance. The degree of oversizing to mitigate PAR is relatively low compared to other self-expanding transcatheter devices. There appears to be no compromise between occurrence of PAR and PPM across this wide range of oversizing.

KW - Aortic Valve

KW - Aortic Valve Insufficiency/epidemiology

KW - Aortic Valve Stenosis

KW - Heart Valve Prosthesis

KW - Humans

KW - Incidence

KW - Pacemaker, Artificial

KW - Predictive Value of Tests

KW - Prosthesis Design

KW - Severity of Illness Index

KW - Transcatheter Aortic Valve Replacement

KW - Treatment Outcome

U2 - 10.4244/EIJ-D-17-01040

DO - 10.4244/EIJ-D-17-01040

M3 - SCORING: Journal article

C2 - 29741486

VL - 14

SP - e511-e518

JO - EUROINTERVENTION

JF - EUROINTERVENTION

SN - 1774-024X

IS - 5

ER -