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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. / Wang, Yumeng; Xu, Xiaoyan; Maglic, Dejan; Dill, Michael T; Mojumdar, Kamalika; Ng, Patrick Kwok-Shing; Jeong, Kang Jin; Tsang, Yiu Huen; Moreno, Daniela; Bhavana, Venkata Hemanjani; Peng, Xinxin; Ge, Zhongqi; Chen, Hu; Li, Jun; Chen, Zhongyuan; Zhang, Huiwen; Han, Leng; Du, Di; Creighton, Chad J; Mills, Gordon B; Camargo, Fernando; Liang, Han; Cancer Genome Atlas Research Network.

In: CELL REP, Vol. 25, No. 5, 30.10.2018, p. 1304-1317.e5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wang, Y, Xu, X, Maglic, D, Dill, MT, Mojumdar, K, Ng, PK-S, Jeong, KJ, Tsang, YH, Moreno, D, Bhavana, VH, Peng, X, Ge, Z, Chen, H, Li, J, Chen, Z, Zhang, H, Han, L, Du, D, Creighton, CJ, Mills, GB, Camargo, F, Liang, H & Cancer Genome Atlas Research Network 2018, 'Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer', CELL REP, vol. 25, no. 5, pp. 1304-1317.e5. https://doi.org/10.1016/j.celrep.2018.10.001

APA

Wang, Y., Xu, X., Maglic, D., Dill, M. T., Mojumdar, K., Ng, P. K-S., Jeong, K. J., Tsang, Y. H., Moreno, D., Bhavana, V. H., Peng, X., Ge, Z., Chen, H., Li, J., Chen, Z., Zhang, H., Han, L., Du, D., Creighton, C. J., ... Cancer Genome Atlas Research Network (2018). Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. CELL REP, 25(5), 1304-1317.e5. https://doi.org/10.1016/j.celrep.2018.10.001

Vancouver

Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK-S et al. Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. CELL REP. 2018 Oct 30;25(5):1304-1317.e5. https://doi.org/10.1016/j.celrep.2018.10.001

Bibtex

@article{f836ebd4b014473db08a5868a0b66ce6,
title = "Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer",
abstract = "Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional {"}omic{"} data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era.",
keywords = "Journal Article",
author = "Yumeng Wang and Xiaoyan Xu and Dejan Maglic and Dill, {Michael T} and Kamalika Mojumdar and Ng, {Patrick Kwok-Shing} and Jeong, {Kang Jin} and Tsang, {Yiu Huen} and Daniela Moreno and Bhavana, {Venkata Hemanjani} and Xinxin Peng and Zhongqi Ge and Hu Chen and Jun Li and Zhongyuan Chen and Huiwen Zhang and Leng Han and Di Du and Creighton, {Chad J} and Mills, {Gordon B} and Fernando Camargo and Han Liang and {Cancer Genome Atlas Research Network} and Guido Sauter",
note = "Copyright {\textcopyright} 2018 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = oct,
day = "30",
doi = "10.1016/j.celrep.2018.10.001",
language = "English",
volume = "25",
pages = "1304--1317.e5",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

AU - Wang, Yumeng

AU - Xu, Xiaoyan

AU - Maglic, Dejan

AU - Dill, Michael T

AU - Mojumdar, Kamalika

AU - Ng, Patrick Kwok-Shing

AU - Jeong, Kang Jin

AU - Tsang, Yiu Huen

AU - Moreno, Daniela

AU - Bhavana, Venkata Hemanjani

AU - Peng, Xinxin

AU - Ge, Zhongqi

AU - Chen, Hu

AU - Li, Jun

AU - Chen, Zhongyuan

AU - Zhang, Huiwen

AU - Han, Leng

AU - Du, Di

AU - Creighton, Chad J

AU - Mills, Gordon B

AU - Camargo, Fernando

AU - Liang, Han

AU - Cancer Genome Atlas Research Network

AU - Sauter, Guido

N1 - Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2018/10/30

Y1 - 2018/10/30

N2 - Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era.

AB - Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic" data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regulators and associated cancer drivers. Our results highlight the importance of Hippo signaling in squamous cell cancers, characterized by frequent amplification of YAP/TAZ, high expression heterogeneity, and significant prognostic patterns. This study represents a systems-biology approach to characterizing key cancer signaling pathways in the post-genomic era.

KW - Journal Article

U2 - 10.1016/j.celrep.2018.10.001

DO - 10.1016/j.celrep.2018.10.001

M3 - SCORING: Journal article

C2 - 30380420

VL - 25

SP - 1304-1317.e5

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -