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Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

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Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. / Greliche, Nicolas; Zeller, Tanja; Wild, Philipp S; Rotival, Maxime; Schillert, Arne; Ziegler, Andreas; Deloukas, Panos; Erdmann, Jeanette; Hengstenberg, Christian; Ouwehand, Willem H; Samani, Nilesh J; Schunkert, Heribert; Munzel, Thomas; Lackner, Karl J; Cambien, François; Goodall, Alison H; Tiret, Laurence; Blankenberg, Stefan; Trégouët, David-Alexandre; CardioGenics Consortium.

In: PLOS ONE, Vol. 7, No. 9, 2012, p. e45863.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Greliche, N, Zeller, T, Wild, PS, Rotival, M, Schillert, A, Ziegler, A, Deloukas, P, Erdmann, J, Hengstenberg, C, Ouwehand, WH, Samani, NJ, Schunkert, H, Munzel, T, Lackner, KJ, Cambien, F, Goodall, AH, Tiret, L, Blankenberg, S, Trégouët, D-A & CardioGenics Consortium 2012, 'Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression', PLOS ONE, vol. 7, no. 9, pp. e45863. https://doi.org/10.1371/journal.pone.0045863

APA

Greliche, N., Zeller, T., Wild, P. S., Rotival, M., Schillert, A., Ziegler, A., Deloukas, P., Erdmann, J., Hengstenberg, C., Ouwehand, W. H., Samani, N. J., Schunkert, H., Munzel, T., Lackner, K. J., Cambien, F., Goodall, A. H., Tiret, L., Blankenberg, S., Trégouët, D-A., & CardioGenics Consortium (2012). Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. PLOS ONE, 7(9), e45863. https://doi.org/10.1371/journal.pone.0045863

Vancouver

Greliche N, Zeller T, Wild PS, Rotival M, Schillert A, Ziegler A et al. Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. PLOS ONE. 2012;7(9):e45863. https://doi.org/10.1371/journal.pone.0045863

Bibtex

@article{87ced96a7f6c4e6ea1a88108d31d9243,
title = "Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression",
abstract = "We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs interactions in a sample of 1,467 individuals for which genome-wide monocyte expression and genotype data were available. Statistical associations that survived multiple testing correction were tested for replication in an independent sample of 758 individuals with both monocyte gene expression and genotype data. In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, COPZ2, KRT9, LRRFIP1, NOD1, PCDHA6, ST5 and TRAF3IP2 genes, supporting the role of hsa-mir-1279 as a regulator of several genes in monocytes. In addition, we identified two robust miSNPs × 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases.",
keywords = "3' Untranslated Regions, Adult, Aged, Case-Control Studies, Coronary Artery Disease/genetics, Female, Gene Expression, Genome-Wide Association Study, Humans, Leukocytes, Mononuclear/metabolism, Linear Models, Linkage Disequilibrium, Male, MicroRNAs/genetics, Middle Aged, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, RNA Interference, Transcriptome",
author = "Nicolas Greliche and Tanja Zeller and Wild, {Philipp S} and Maxime Rotival and Arne Schillert and Andreas Ziegler and Panos Deloukas and Jeanette Erdmann and Christian Hengstenberg and Ouwehand, {Willem H} and Samani, {Nilesh J} and Heribert Schunkert and Thomas Munzel and Lackner, {Karl J} and Fran{\c c}ois Cambien and Goodall, {Alison H} and Laurence Tiret and Stefan Blankenberg and David-Alexandre Tr{\'e}gou{\"e}t and {CardioGenics Consortium}",
year = "2012",
doi = "10.1371/journal.pone.0045863",
language = "English",
volume = "7",
pages = "e45863",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

AU - Greliche, Nicolas

AU - Zeller, Tanja

AU - Wild, Philipp S

AU - Rotival, Maxime

AU - Schillert, Arne

AU - Ziegler, Andreas

AU - Deloukas, Panos

AU - Erdmann, Jeanette

AU - Hengstenberg, Christian

AU - Ouwehand, Willem H

AU - Samani, Nilesh J

AU - Schunkert, Heribert

AU - Munzel, Thomas

AU - Lackner, Karl J

AU - Cambien, François

AU - Goodall, Alison H

AU - Tiret, Laurence

AU - Blankenberg, Stefan

AU - Trégouët, David-Alexandre

AU - CardioGenics Consortium

PY - 2012

Y1 - 2012

N2 - We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs interactions in a sample of 1,467 individuals for which genome-wide monocyte expression and genotype data were available. Statistical associations that survived multiple testing correction were tested for replication in an independent sample of 758 individuals with both monocyte gene expression and genotype data. In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, COPZ2, KRT9, LRRFIP1, NOD1, PCDHA6, ST5 and TRAF3IP2 genes, supporting the role of hsa-mir-1279 as a regulator of several genes in monocytes. In addition, we identified two robust miSNPs × 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases.

AB - We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs interactions in a sample of 1,467 individuals for which genome-wide monocyte expression and genotype data were available. Statistical associations that survived multiple testing correction were tested for replication in an independent sample of 758 individuals with both monocyte gene expression and genotype data. In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, COPZ2, KRT9, LRRFIP1, NOD1, PCDHA6, ST5 and TRAF3IP2 genes, supporting the role of hsa-mir-1279 as a regulator of several genes in monocytes. In addition, we identified two robust miSNPs × 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes.As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases.

KW - 3' Untranslated Regions

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Coronary Artery Disease/genetics

KW - Female

KW - Gene Expression

KW - Genome-Wide Association Study

KW - Humans

KW - Leukocytes, Mononuclear/metabolism

KW - Linear Models

KW - Linkage Disequilibrium

KW - Male

KW - MicroRNAs/genetics

KW - Middle Aged

KW - Oligonucleotide Array Sequence Analysis

KW - Polymorphism, Single Nucleotide

KW - RNA Interference

KW - Transcriptome

U2 - 10.1371/journal.pone.0045863

DO - 10.1371/journal.pone.0045863

M3 - SCORING: Journal article

C2 - 23029284

VL - 7

SP - e45863

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 9

ER -