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Comprehensive characterization of cellular immune responses following Ebola virus infection

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Comprehensive characterization of cellular immune responses following Ebola virus infection. / Dahlke, Christine; Lunemann, Sebastian; Kasonta, Rahel; Kreuels, Benno; Schmiedel, Stefan; Ly, My L; Fehling, Sarah K; Strecker, Thomas; Becker, Stephan; Altfeld, Marcus; Sow, Abdourahmane; Lohse, Ansgar W; Muñoz-Fontela, César; Addo, Marylyn M.

In: J INFECT DIS, Vol. 215, No. 2, 15.01.2017, p. 287-292.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dahlke, C, Lunemann, S, Kasonta, R, Kreuels, B, Schmiedel, S, Ly, ML, Fehling, SK, Strecker, T, Becker, S, Altfeld, M, Sow, A, Lohse, AW, Muñoz-Fontela, C & Addo, MM 2017, 'Comprehensive characterization of cellular immune responses following Ebola virus infection', J INFECT DIS, vol. 215, no. 2, pp. 287-292. https://doi.org/10.1093/infdis/jiw508

APA

Dahlke, C., Lunemann, S., Kasonta, R., Kreuels, B., Schmiedel, S., Ly, M. L., Fehling, S. K., Strecker, T., Becker, S., Altfeld, M., Sow, A., Lohse, A. W., Muñoz-Fontela, C., & Addo, M. M. (2017). Comprehensive characterization of cellular immune responses following Ebola virus infection. J INFECT DIS, 215(2), 287-292. https://doi.org/10.1093/infdis/jiw508

Vancouver

Dahlke C, Lunemann S, Kasonta R, Kreuels B, Schmiedel S, Ly ML et al. Comprehensive characterization of cellular immune responses following Ebola virus infection. J INFECT DIS. 2017 Jan 15;215(2):287-292. https://doi.org/10.1093/infdis/jiw508

Bibtex

@article{042346fe2ec949b193d072beec38e935,
title = "Comprehensive characterization of cellular immune responses following Ebola virus infection",
abstract = "The West-African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and antigen-specificity of T-cells in Ebola survivors are scarce and our understanding of EVD-pathophysiology is limited.The care for an EVD-survivor, who cleared the infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate persistence of T-cell activation well beyond viral clearance and detect Ebola-specific T-cells. Our study provides significant insights into lymphocyte specificity during the re-convalescent phase of EVD and may inform novel strategies to treat EVD.",
author = "Christine Dahlke and Sebastian Lunemann and Rahel Kasonta and Benno Kreuels and Stefan Schmiedel and Ly, {My L} and Fehling, {Sarah K} and Thomas Strecker and Stephan Becker and Marcus Altfeld and Abdourahmane Sow and Lohse, {Ansgar W} and C{\'e}sar Mu{\~n}oz-Fontela and Addo, {Marylyn M}",
note = "{\textcopyright} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.",
year = "2017",
month = jan,
day = "15",
doi = "10.1093/infdis/jiw508",
language = "English",
volume = "215",
pages = "287--292",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Comprehensive characterization of cellular immune responses following Ebola virus infection

AU - Dahlke, Christine

AU - Lunemann, Sebastian

AU - Kasonta, Rahel

AU - Kreuels, Benno

AU - Schmiedel, Stefan

AU - Ly, My L

AU - Fehling, Sarah K

AU - Strecker, Thomas

AU - Becker, Stephan

AU - Altfeld, Marcus

AU - Sow, Abdourahmane

AU - Lohse, Ansgar W

AU - Muñoz-Fontela, César

AU - Addo, Marylyn M

N1 - © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - The West-African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and antigen-specificity of T-cells in Ebola survivors are scarce and our understanding of EVD-pathophysiology is limited.The care for an EVD-survivor, who cleared the infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate persistence of T-cell activation well beyond viral clearance and detect Ebola-specific T-cells. Our study provides significant insights into lymphocyte specificity during the re-convalescent phase of EVD and may inform novel strategies to treat EVD.

AB - The West-African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and antigen-specificity of T-cells in Ebola survivors are scarce and our understanding of EVD-pathophysiology is limited.The care for an EVD-survivor, who cleared the infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate persistence of T-cell activation well beyond viral clearance and detect Ebola-specific T-cells. Our study provides significant insights into lymphocyte specificity during the re-convalescent phase of EVD and may inform novel strategies to treat EVD.

U2 - 10.1093/infdis/jiw508

DO - 10.1093/infdis/jiw508

M3 - SCORING: Journal article

C2 - 27799354

VL - 215

SP - 287

EP - 292

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 2

ER -