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Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes

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Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes. / Ganster, Christina; Müller-Thomas, Catharina; Haferlach, Claudia; Strupp, Corinna; Ogata, Kiyoyuki; Germing, Ulrich; Hildebrandt, Barbara; Mallo, Mar; Lübbert, Michael; Müller, Christel; Solé, Francesc; Götze, Katharina S; Vandenberghe, Peter; Göhring, Gudrun; Steinmetz, Tilman; Kröger, Nicolaus; Platzbecker, Uwe; Söling, Ulrike; Raynaud, Sophie; Shirneshan, Katayoon; Schanz, Julie; Haase, Detlef.

In: GENE CHROMOSOME CANC, Vol. 58, No. 10, 10.2019, p. 689-697.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ganster, C, Müller-Thomas, C, Haferlach, C, Strupp, C, Ogata, K, Germing, U, Hildebrandt, B, Mallo, M, Lübbert, M, Müller, C, Solé, F, Götze, KS, Vandenberghe, P, Göhring, G, Steinmetz, T, Kröger, N, Platzbecker, U, Söling, U, Raynaud, S, Shirneshan, K, Schanz, J & Haase, D 2019, 'Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes', GENE CHROMOSOME CANC, vol. 58, no. 10, pp. 689-697. https://doi.org/10.1002/gcc.22760

APA

Ganster, C., Müller-Thomas, C., Haferlach, C., Strupp, C., Ogata, K., Germing, U., Hildebrandt, B., Mallo, M., Lübbert, M., Müller, C., Solé, F., Götze, K. S., Vandenberghe, P., Göhring, G., Steinmetz, T., Kröger, N., Platzbecker, U., Söling, U., Raynaud, S., ... Haase, D. (2019). Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes. GENE CHROMOSOME CANC, 58(10), 689-697. https://doi.org/10.1002/gcc.22760

Vancouver

Ganster C, Müller-Thomas C, Haferlach C, Strupp C, Ogata K, Germing U et al. Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes. GENE CHROMOSOME CANC. 2019 Oct;58(10):689-697. https://doi.org/10.1002/gcc.22760

Bibtex

@article{f13c80307f534373992347ccb6c5e714,
title = "Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes",
abstract = "The karyotype is a strong independent prognostic factor in myelodysplastic syndromes (MDS). Since the implementation of the new comprehensive cytogenetic scoring system for MDS, chromosome 7 anomalies are no longer generally assigned to poor risk features but are thoroughly separated. However, der(1;7)(q10;p10), hereinafter der(1;7), is merged into the group labeled {"}any other single{"} and belongs to the intermediate risk group, just by definition due to lack of adequate clinical data. The aim of our international collaborative was to clarify the {"}real{"} prognostic impact of der(1;7) on a homogenous and well-documented data base. We performed detailed analysis of 63 MDS patients with isolated der(1;7) constituting the largest cohort hitherto reported. Furthermore, clinical data are compared with those of patients with isolated del(7q) and isolated monosomy 7. Median overall survival (OS) of patients with der(1;7) is 26 months (hazard ratio (HR) 0.91 for del(7q) vs der(1;7) and 2.53 for monosomy 7 vs der(1;7)). The der(1;7) is associated with profound thrombocytopenia most probably causing the reduced OS which is in striking contrast to the low risk for AML transformation (HR 3.89 for del(7q) vs der(1;7) and 5.88 for monosomy 7 vs der(1;7)). Molecular karyotyping indicates that der(1;7) is generated in a single step during mitosis and that a chromosomal imbalance rather than a single disrupted gene accounts for malignancy. Thus, the current cytogenetic scoring system assigning isolated der(1;7) to the intermediate risk group is now confirmed by a sufficient data set.",
author = "Christina Ganster and Catharina M{\"u}ller-Thomas and Claudia Haferlach and Corinna Strupp and Kiyoyuki Ogata and Ulrich Germing and Barbara Hildebrandt and Mar Mallo and Michael L{\"u}bbert and Christel M{\"u}ller and Francesc Sol{\'e} and G{\"o}tze, {Katharina S} and Peter Vandenberghe and Gudrun G{\"o}hring and Tilman Steinmetz and Nicolaus Kr{\"o}ger and Uwe Platzbecker and Ulrike S{\"o}ling and Sophie Raynaud and Katayoon Shirneshan and Julie Schanz and Detlef Haase",
note = "{\textcopyright} 2019 Wiley Periodicals, Inc.",
year = "2019",
month = oct,
doi = "10.1002/gcc.22760",
language = "English",
volume = "58",
pages = "689--697",
journal = "GENE CHROMOSOME CANC",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Comprehensive analysis of isolated der(1;7)(q10;p10) in a large international homogenous cohort of patients with myelodysplastic syndromes

AU - Ganster, Christina

AU - Müller-Thomas, Catharina

AU - Haferlach, Claudia

AU - Strupp, Corinna

AU - Ogata, Kiyoyuki

AU - Germing, Ulrich

AU - Hildebrandt, Barbara

AU - Mallo, Mar

AU - Lübbert, Michael

AU - Müller, Christel

AU - Solé, Francesc

AU - Götze, Katharina S

AU - Vandenberghe, Peter

AU - Göhring, Gudrun

AU - Steinmetz, Tilman

AU - Kröger, Nicolaus

AU - Platzbecker, Uwe

AU - Söling, Ulrike

AU - Raynaud, Sophie

AU - Shirneshan, Katayoon

AU - Schanz, Julie

AU - Haase, Detlef

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/10

Y1 - 2019/10

N2 - The karyotype is a strong independent prognostic factor in myelodysplastic syndromes (MDS). Since the implementation of the new comprehensive cytogenetic scoring system for MDS, chromosome 7 anomalies are no longer generally assigned to poor risk features but are thoroughly separated. However, der(1;7)(q10;p10), hereinafter der(1;7), is merged into the group labeled "any other single" and belongs to the intermediate risk group, just by definition due to lack of adequate clinical data. The aim of our international collaborative was to clarify the "real" prognostic impact of der(1;7) on a homogenous and well-documented data base. We performed detailed analysis of 63 MDS patients with isolated der(1;7) constituting the largest cohort hitherto reported. Furthermore, clinical data are compared with those of patients with isolated del(7q) and isolated monosomy 7. Median overall survival (OS) of patients with der(1;7) is 26 months (hazard ratio (HR) 0.91 for del(7q) vs der(1;7) and 2.53 for monosomy 7 vs der(1;7)). The der(1;7) is associated with profound thrombocytopenia most probably causing the reduced OS which is in striking contrast to the low risk for AML transformation (HR 3.89 for del(7q) vs der(1;7) and 5.88 for monosomy 7 vs der(1;7)). Molecular karyotyping indicates that der(1;7) is generated in a single step during mitosis and that a chromosomal imbalance rather than a single disrupted gene accounts for malignancy. Thus, the current cytogenetic scoring system assigning isolated der(1;7) to the intermediate risk group is now confirmed by a sufficient data set.

AB - The karyotype is a strong independent prognostic factor in myelodysplastic syndromes (MDS). Since the implementation of the new comprehensive cytogenetic scoring system for MDS, chromosome 7 anomalies are no longer generally assigned to poor risk features but are thoroughly separated. However, der(1;7)(q10;p10), hereinafter der(1;7), is merged into the group labeled "any other single" and belongs to the intermediate risk group, just by definition due to lack of adequate clinical data. The aim of our international collaborative was to clarify the "real" prognostic impact of der(1;7) on a homogenous and well-documented data base. We performed detailed analysis of 63 MDS patients with isolated der(1;7) constituting the largest cohort hitherto reported. Furthermore, clinical data are compared with those of patients with isolated del(7q) and isolated monosomy 7. Median overall survival (OS) of patients with der(1;7) is 26 months (hazard ratio (HR) 0.91 for del(7q) vs der(1;7) and 2.53 for monosomy 7 vs der(1;7)). The der(1;7) is associated with profound thrombocytopenia most probably causing the reduced OS which is in striking contrast to the low risk for AML transformation (HR 3.89 for del(7q) vs der(1;7) and 5.88 for monosomy 7 vs der(1;7)). Molecular karyotyping indicates that der(1;7) is generated in a single step during mitosis and that a chromosomal imbalance rather than a single disrupted gene accounts for malignancy. Thus, the current cytogenetic scoring system assigning isolated der(1;7) to the intermediate risk group is now confirmed by a sufficient data set.

U2 - 10.1002/gcc.22760

DO - 10.1002/gcc.22760

M3 - SCORING: Journal article

C2 - 30994215

VL - 58

SP - 689

EP - 697

JO - GENE CHROMOSOME CANC

JF - GENE CHROMOSOME CANC

SN - 1045-2257

IS - 10

ER -