Compositions and Methods for Boosting the Efficacy of Adoptive Cellular Immunotherapy.

Abstract: The present disclosure provides compositions and methods for boosting, augmenting or enhancing the efficacy of the adoptive cellular immunotherapy by using modified T cells expressing an antigen binding protein in conjunction with modified cells (such as hematopoietic progenitor cells, modified human immune system cells or a combination thereof) expressing the antigen spe - cifically bound by the antigen binding protein of the modified T cells.