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Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study

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Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study. / Zahn, Daniela; Weidner, Gerdi; Beyersmann, Jan; Smits, Jacqueline M A; Deng, Mario C; Kaczmarek, Ingo; Meyer, Sven; Reichenspurner, Hermann; Mehlhorn, Uwe; Wagner, Florian M; Spaderna, Heike.

In: TRANSPL INT, Vol. 23, No. 12, 12.2010, p. 1223-1232.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zahn, D, Weidner, G, Beyersmann, J, Smits, JMA, Deng, MC, Kaczmarek, I, Meyer, S, Reichenspurner, H, Mehlhorn, U, Wagner, FM & Spaderna, H 2010, 'Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study', TRANSPL INT, vol. 23, no. 12, pp. 1223-1232. https://doi.org/10.1111/j.1432-2277.2010.01133.x

APA

Zahn, D., Weidner, G., Beyersmann, J., Smits, J. M. A., Deng, M. C., Kaczmarek, I., Meyer, S., Reichenspurner, H., Mehlhorn, U., Wagner, F. M., & Spaderna, H. (2010). Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study. TRANSPL INT, 23(12), 1223-1232. https://doi.org/10.1111/j.1432-2277.2010.01133.x

Vancouver

Zahn D, Weidner G, Beyersmann J, Smits JMA, Deng MC, Kaczmarek I et al. Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study. TRANSPL INT. 2010 Dec;23(12):1223-1232. https://doi.org/10.1111/j.1432-2277.2010.01133.x

Bibtex

@article{02737ada48174469857a2fcac2f1c67b,
title = "Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study",
abstract = "We evaluated two composite risk scores, (Heart Failure Survival Score, HFSS; German Transplant Society Score, GTSS), and depression as predictors of mortality and competing waiting-list outcomes [high-urgency transplantation (HU-HTx), elective transplantation, delisting because of clinical improvement] in 318 heart transplant (HTx) candidates (18% women; aged 53 ± 11 years) from 17 hospitals and newly registered with Eurotransplant. Demographic variables and depression (Hospital Anxiety and Depression Scale, HADS) were assessed using questionnaires. Variables to compute HFSS and GTSS, age, medications, and outcomes were provided by Eurotransplant. At 12 months, 33 patients died, 83 received urgent HTx, 30 elective HTx, and 17 were delisted because of improvement. Applying cause-specific Cox regressions, only the HFSS was significantly associated with 1-year mortality [HR = 0.64 (95% CI = 0.43-0.95), P = 0.029]. The GTSS was the strongest predictor of HU-HTx [HR= 1.02 (95% CI = 1.01-1.02), P < 0.001]. Low depression scores contributed significantly to clinical improvement, even after adjusting for age and risk scores [HADS: HR = 0.12 (95% CI = 0.02-0.89), P = 0.039]. These findings confirm the usefulness of composite risk scores for the prediction of mortality and HU-HTx, validating both scores for their intended use. The finding that depression was an independent predictor of the waiting-list outcome clinical improvement suggests that considering patients' psychological attributes in addition to their medical characteristics is advisable.",
keywords = "Adolescent, Adult, Aged, Depression/psychology, Female, Heart Failure/mortality, Heart Transplantation/mortality, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Assessment, Treatment Outcome, Waiting Lists/mortality",
author = "Daniela Zahn and Gerdi Weidner and Jan Beyersmann and Smits, {Jacqueline M A} and Deng, {Mario C} and Ingo Kaczmarek and Sven Meyer and Hermann Reichenspurner and Uwe Mehlhorn and Wagner, {Florian M} and Heike Spaderna",
note = "{\textcopyright} 2010 The Authors. Journal compilation {\textcopyright} 2010 European Society for Organ Transplantation.",
year = "2010",
month = dec,
doi = "10.1111/j.1432-2277.2010.01133.x",
language = "English",
volume = "23",
pages = "1223--1232",
journal = "TRANSPL INT",
issn = "0934-0874",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Composite risk scores and depression as predictors of competing waiting-list outcomes: the Waiting for a New Heart Study

AU - Zahn, Daniela

AU - Weidner, Gerdi

AU - Beyersmann, Jan

AU - Smits, Jacqueline M A

AU - Deng, Mario C

AU - Kaczmarek, Ingo

AU - Meyer, Sven

AU - Reichenspurner, Hermann

AU - Mehlhorn, Uwe

AU - Wagner, Florian M

AU - Spaderna, Heike

N1 - © 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation.

PY - 2010/12

Y1 - 2010/12

N2 - We evaluated two composite risk scores, (Heart Failure Survival Score, HFSS; German Transplant Society Score, GTSS), and depression as predictors of mortality and competing waiting-list outcomes [high-urgency transplantation (HU-HTx), elective transplantation, delisting because of clinical improvement] in 318 heart transplant (HTx) candidates (18% women; aged 53 ± 11 years) from 17 hospitals and newly registered with Eurotransplant. Demographic variables and depression (Hospital Anxiety and Depression Scale, HADS) were assessed using questionnaires. Variables to compute HFSS and GTSS, age, medications, and outcomes were provided by Eurotransplant. At 12 months, 33 patients died, 83 received urgent HTx, 30 elective HTx, and 17 were delisted because of improvement. Applying cause-specific Cox regressions, only the HFSS was significantly associated with 1-year mortality [HR = 0.64 (95% CI = 0.43-0.95), P = 0.029]. The GTSS was the strongest predictor of HU-HTx [HR= 1.02 (95% CI = 1.01-1.02), P < 0.001]. Low depression scores contributed significantly to clinical improvement, even after adjusting for age and risk scores [HADS: HR = 0.12 (95% CI = 0.02-0.89), P = 0.039]. These findings confirm the usefulness of composite risk scores for the prediction of mortality and HU-HTx, validating both scores for their intended use. The finding that depression was an independent predictor of the waiting-list outcome clinical improvement suggests that considering patients' psychological attributes in addition to their medical characteristics is advisable.

AB - We evaluated two composite risk scores, (Heart Failure Survival Score, HFSS; German Transplant Society Score, GTSS), and depression as predictors of mortality and competing waiting-list outcomes [high-urgency transplantation (HU-HTx), elective transplantation, delisting because of clinical improvement] in 318 heart transplant (HTx) candidates (18% women; aged 53 ± 11 years) from 17 hospitals and newly registered with Eurotransplant. Demographic variables and depression (Hospital Anxiety and Depression Scale, HADS) were assessed using questionnaires. Variables to compute HFSS and GTSS, age, medications, and outcomes were provided by Eurotransplant. At 12 months, 33 patients died, 83 received urgent HTx, 30 elective HTx, and 17 were delisted because of improvement. Applying cause-specific Cox regressions, only the HFSS was significantly associated with 1-year mortality [HR = 0.64 (95% CI = 0.43-0.95), P = 0.029]. The GTSS was the strongest predictor of HU-HTx [HR= 1.02 (95% CI = 1.01-1.02), P < 0.001]. Low depression scores contributed significantly to clinical improvement, even after adjusting for age and risk scores [HADS: HR = 0.12 (95% CI = 0.02-0.89), P = 0.039]. These findings confirm the usefulness of composite risk scores for the prediction of mortality and HU-HTx, validating both scores for their intended use. The finding that depression was an independent predictor of the waiting-list outcome clinical improvement suggests that considering patients' psychological attributes in addition to their medical characteristics is advisable.

KW - Adolescent

KW - Adult

KW - Aged

KW - Depression/psychology

KW - Female

KW - Heart Failure/mortality

KW - Heart Transplantation/mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Treatment Outcome

KW - Waiting Lists/mortality

U2 - 10.1111/j.1432-2277.2010.01133.x

DO - 10.1111/j.1432-2277.2010.01133.x

M3 - SCORING: Journal article

C2 - 20630044

VL - 23

SP - 1223

EP - 1232

JO - TRANSPL INT

JF - TRANSPL INT

SN - 0934-0874

IS - 12

ER -