Complication Rates of Catheter Ablation of Atrial Fibrillation in Patients Aged ≥75 Years versus
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Complication Rates of Catheter Ablation of Atrial Fibrillation in Patients Aged ≥75 Years versus. / Moser, Julia M; Willems, Stephan; Andresen, Dietrich; Brachmann, Johannes; Eckardt, Lars; Hoffmann, Ellen; Kuck, Karl-Heinz; Lewalter, Thorsten; Schumacher, Burghard; Spitzer, Stefan G; Hochadel, Matthias; Senges, Jochen; Hoffmann, Boris A.
In: J CARDIOVASC ELECTR, Vol. 28, No. 3, 03.2017, p. 258-265.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Complication Rates of Catheter Ablation of Atrial Fibrillation in Patients Aged ≥75 Years versus
AU - Moser, Julia M
AU - Willems, Stephan
AU - Andresen, Dietrich
AU - Brachmann, Johannes
AU - Eckardt, Lars
AU - Hoffmann, Ellen
AU - Kuck, Karl-Heinz
AU - Lewalter, Thorsten
AU - Schumacher, Burghard
AU - Spitzer, Stefan G
AU - Hochadel, Matthias
AU - Senges, Jochen
AU - Hoffmann, Boris A
N1 - © 2016 Wiley Periodicals, Inc.
PY - 2017/3
Y1 - 2017/3
N2 - INTRODUCTION: Despite a rising demand for catheter ablation (CA) of atrial fibrillation (AF) in an elderly population, complication and success rates are not fully elucidated. We sought to compare complication rates of CA of AF in patients ≥75 versus <75 years of age.METHODS AND RESULTS: Patients with symptomatic, drug-refractory AF were prospectively enrolled from January 2007 to 2010 in this multicenter study. A total of 4,449 patients, group 1 ≥75 years and group 2 <75 years (n = 227, age 77.3 ± 2.2 vs. 59.7 ± 9.8 years, 52.0% vs. n = 4,222, 68.9% male, CHA2 DS2 -VASc-Score 3.7 ± 1.0 vs. 1.7 ± 1.2; P < 0.001, respectively), with paroxysmal AF (59.9% in group 1 vs. 63.3% in group 2, P = 0.30), and persistent AF (34.8% in group 1 vs. 29.4% in group 2, P = 0.082) underwent CA of AF. A centralized follow-up was obtained in 4,347 patients by the Institute for Myocardial Infarction Research (IHF, Ludwigshafen). There was a significant difference between periprocedural stroke rates in the elderly versus the younger cohort (1.3% vs. 0.1%, P < 0.01). In-hospital severe nonfatal complications did not differ significantly between the groups (4.4% vs. 2.7%, P = 0.14). Other procedure-related, in-hospital complications were not significantly different. After a mean follow-up of 472 ± 99 days (group 1) and 477 ± 94 days (group 2), no differences were found in complication rates.CONCLUSION: CA of AF in patients ≥75 years is associated with higher in-hospital stroke rates. In a 1-year follow-up, complication rates do not differ between the groups.
AB - INTRODUCTION: Despite a rising demand for catheter ablation (CA) of atrial fibrillation (AF) in an elderly population, complication and success rates are not fully elucidated. We sought to compare complication rates of CA of AF in patients ≥75 versus <75 years of age.METHODS AND RESULTS: Patients with symptomatic, drug-refractory AF were prospectively enrolled from January 2007 to 2010 in this multicenter study. A total of 4,449 patients, group 1 ≥75 years and group 2 <75 years (n = 227, age 77.3 ± 2.2 vs. 59.7 ± 9.8 years, 52.0% vs. n = 4,222, 68.9% male, CHA2 DS2 -VASc-Score 3.7 ± 1.0 vs. 1.7 ± 1.2; P < 0.001, respectively), with paroxysmal AF (59.9% in group 1 vs. 63.3% in group 2, P = 0.30), and persistent AF (34.8% in group 1 vs. 29.4% in group 2, P = 0.082) underwent CA of AF. A centralized follow-up was obtained in 4,347 patients by the Institute for Myocardial Infarction Research (IHF, Ludwigshafen). There was a significant difference between periprocedural stroke rates in the elderly versus the younger cohort (1.3% vs. 0.1%, P < 0.01). In-hospital severe nonfatal complications did not differ significantly between the groups (4.4% vs. 2.7%, P = 0.14). Other procedure-related, in-hospital complications were not significantly different. After a mean follow-up of 472 ± 99 days (group 1) and 477 ± 94 days (group 2), no differences were found in complication rates.CONCLUSION: CA of AF in patients ≥75 years is associated with higher in-hospital stroke rates. In a 1-year follow-up, complication rates do not differ between the groups.
KW - Action Potentials
KW - Age Factors
KW - Aged
KW - Atrial Fibrillation/diagnosis
KW - Catheter Ablation/adverse effects
KW - Disease-Free Survival
KW - Female
KW - Germany
KW - Heart Rate
KW - Humans
KW - Kaplan-Meier Estimate
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Pulmonary Veins/physiopathology
KW - Registries
KW - Risk Factors
KW - Stroke/etiology
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1111/jce.13142
DO - 10.1111/jce.13142
M3 - SCORING: Journal article
C2 - 27925337
VL - 28
SP - 258
EP - 265
JO - J CARDIOVASC ELECTR
JF - J CARDIOVASC ELECTR
SN - 1045-3873
IS - 3
ER -
