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Complex variability of intron 40 of the von Willebrand factor (vWF) gene.

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Complex variability of intron 40 of the von Willebrand factor (vWF) gene. / Hering, Sandra; Augustin, Christa; Edelmann, Jeanett; Heidel, Micaela; Chamaon, Kathrin; Dressler, Jan; Szibor, Reinhard.

In: INT J LEGAL MED, Vol. 122, No. 1, 1, 2008, p. 67-71.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hering, S, Augustin, C, Edelmann, J, Heidel, M, Chamaon, K, Dressler, J & Szibor, R 2008, 'Complex variability of intron 40 of the von Willebrand factor (vWF) gene.', INT J LEGAL MED, vol. 122, no. 1, 1, pp. 67-71. <http://www.ncbi.nlm.nih.gov/pubmed/17273877?dopt=Citation>

APA

Hering, S., Augustin, C., Edelmann, J., Heidel, M., Chamaon, K., Dressler, J., & Szibor, R. (2008). Complex variability of intron 40 of the von Willebrand factor (vWF) gene. INT J LEGAL MED, 122(1), 67-71. [1]. http://www.ncbi.nlm.nih.gov/pubmed/17273877?dopt=Citation

Vancouver

Hering S, Augustin C, Edelmann J, Heidel M, Chamaon K, Dressler J et al. Complex variability of intron 40 of the von Willebrand factor (vWF) gene. INT J LEGAL MED. 2008;122(1):67-71. 1.

Bibtex

@article{85117912e2a248438aaa42b8d12ef76c,
title = "Complex variability of intron 40 of the von Willebrand factor (vWF) gene.",
abstract = "Intron 40 of the von Willebrand factor (vWF) gene exhibits a highly variable region of about 0.65 kb, which contains 5 juxtaposed STRs. We sequenced 0.65 kb amplicons from 68 chromosomes and found 2 frequent indel polymorphisms and 5 SNPs. The 68 chromosomes investigated here presented a total of 47 different haplotypes. Regarding the SNP allele distribution in our sample, we arranged our results of the vWF intron 40 into a system of 3 haplotypes, i.e. haplotypes a, b and c. Our review may be valuable in further optimising vWF typing in forensic applications and in avoiding pitfalls. Further attempts to develop sophisticated techniques may soon enable haplotyping using autosomale STR clusters.",
author = "Sandra Hering and Christa Augustin and Jeanett Edelmann and Micaela Heidel and Kathrin Chamaon and Jan Dressler and Reinhard Szibor",
year = "2008",
language = "Deutsch",
volume = "122",
pages = "67--71",
journal = "INT J LEGAL MED",
issn = "0937-9827",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Complex variability of intron 40 of the von Willebrand factor (vWF) gene.

AU - Hering, Sandra

AU - Augustin, Christa

AU - Edelmann, Jeanett

AU - Heidel, Micaela

AU - Chamaon, Kathrin

AU - Dressler, Jan

AU - Szibor, Reinhard

PY - 2008

Y1 - 2008

N2 - Intron 40 of the von Willebrand factor (vWF) gene exhibits a highly variable region of about 0.65 kb, which contains 5 juxtaposed STRs. We sequenced 0.65 kb amplicons from 68 chromosomes and found 2 frequent indel polymorphisms and 5 SNPs. The 68 chromosomes investigated here presented a total of 47 different haplotypes. Regarding the SNP allele distribution in our sample, we arranged our results of the vWF intron 40 into a system of 3 haplotypes, i.e. haplotypes a, b and c. Our review may be valuable in further optimising vWF typing in forensic applications and in avoiding pitfalls. Further attempts to develop sophisticated techniques may soon enable haplotyping using autosomale STR clusters.

AB - Intron 40 of the von Willebrand factor (vWF) gene exhibits a highly variable region of about 0.65 kb, which contains 5 juxtaposed STRs. We sequenced 0.65 kb amplicons from 68 chromosomes and found 2 frequent indel polymorphisms and 5 SNPs. The 68 chromosomes investigated here presented a total of 47 different haplotypes. Regarding the SNP allele distribution in our sample, we arranged our results of the vWF intron 40 into a system of 3 haplotypes, i.e. haplotypes a, b and c. Our review may be valuable in further optimising vWF typing in forensic applications and in avoiding pitfalls. Further attempts to develop sophisticated techniques may soon enable haplotyping using autosomale STR clusters.

M3 - SCORING: Zeitschriftenaufsatz

VL - 122

SP - 67

EP - 71

JO - INT J LEGAL MED

JF - INT J LEGAL MED

SN - 0937-9827

IS - 1

M1 - 1

ER -