Completion of neuronal remodeling prompts myelination along developing motor axon branches
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Completion of neuronal remodeling prompts myelination along developing motor axon branches. / Wang, Mengzhe; Kleele, Tatjana; Xiao, Yan; Plucinska, Gabriela; Avramopoulos, Petros; Engelhardt, Stefan; Schwab, Markus H; Kneussel, Matthias; Czopka, Tim; Sherman, Diane L; Brophy, Peter J; Misgeld, Thomas; Brill, Monika S.
In: J CELL BIOL, Vol. 220, No. 4, e201911114, 05.04.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Completion of neuronal remodeling prompts myelination along developing motor axon branches
AU - Wang, Mengzhe
AU - Kleele, Tatjana
AU - Xiao, Yan
AU - Plucinska, Gabriela
AU - Avramopoulos, Petros
AU - Engelhardt, Stefan
AU - Schwab, Markus H
AU - Kneussel, Matthias
AU - Czopka, Tim
AU - Sherman, Diane L
AU - Brophy, Peter J
AU - Misgeld, Thomas
AU - Brill, Monika S
N1 - © 2021 Wang et al.
PY - 2021/4/5
Y1 - 2021/4/5
N2 - Neuronal remodeling and myelination are two fundamental processes during neurodevelopment. How they influence each other remains largely unknown, even though their coordinated execution is critical for circuit function and often disrupted in neuropsychiatric disorders. It is unclear whether myelination stabilizes axon branches during remodeling or whether ongoing remodeling delays myelination. By modulating synaptic transmission, cytoskeletal dynamics, and axonal transport in mouse motor axons, we show that local axon remodeling delays myelination onset and node formation. Conversely, glial differentiation does not determine the outcome of axon remodeling. Delayed myelination is not due to a limited supply of structural components of the axon-glial unit but rather is triggered by increased transport of signaling factors that initiate myelination, such as neuregulin. Further, transport of promyelinating signals is regulated via local cytoskeletal maturation related to activity-dependent competition. Our study reveals an axon branch-specific fine-tuning mechanism that locally coordinates axon remodeling and myelination.
AB - Neuronal remodeling and myelination are two fundamental processes during neurodevelopment. How they influence each other remains largely unknown, even though their coordinated execution is critical for circuit function and often disrupted in neuropsychiatric disorders. It is unclear whether myelination stabilizes axon branches during remodeling or whether ongoing remodeling delays myelination. By modulating synaptic transmission, cytoskeletal dynamics, and axonal transport in mouse motor axons, we show that local axon remodeling delays myelination onset and node formation. Conversely, glial differentiation does not determine the outcome of axon remodeling. Delayed myelination is not due to a limited supply of structural components of the axon-glial unit but rather is triggered by increased transport of signaling factors that initiate myelination, such as neuregulin. Further, transport of promyelinating signals is regulated via local cytoskeletal maturation related to activity-dependent competition. Our study reveals an axon branch-specific fine-tuning mechanism that locally coordinates axon remodeling and myelination.
U2 - 10.1083/jcb.201911114
DO - 10.1083/jcb.201911114
M3 - SCORING: Journal article
C2 - 33538762
VL - 220
JO - J CELL BIOL
JF - J CELL BIOL
SN - 0021-9525
IS - 4
M1 - e201911114
ER -
