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Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.

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Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice. / Richter, Claus-Peter; Münscher, Adrian; Machado, Danielle Santana; Wondisford, Fredric E; Ortiga-Carvalho, Tania M.

In: CELL PHYSIOL BIOCHEM, Vol. 28, No. 5, 5, 2011, p. 997-1008.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Richter, C-P, Münscher, A, Machado, DS, Wondisford, FE & Ortiga-Carvalho, TM 2011, 'Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.', CELL PHYSIOL BIOCHEM, vol. 28, no. 5, 5, pp. 997-1008. <http://www.ncbi.nlm.nih.gov/pubmed/22178950?dopt=Citation>

APA

Richter, C-P., Münscher, A., Machado, D. S., Wondisford, F. E., & Ortiga-Carvalho, T. M. (2011). Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice. CELL PHYSIOL BIOCHEM, 28(5), 997-1008. [5]. http://www.ncbi.nlm.nih.gov/pubmed/22178950?dopt=Citation

Vancouver

Richter C-P, Münscher A, Machado DS, Wondisford FE, Ortiga-Carvalho TM. Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice. CELL PHYSIOL BIOCHEM. 2011;28(5):997-1008. 5.

Bibtex

@article{1ab62ace479f42108cecb65667bfabf2,
title = "Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.",
abstract = "Thyroid hormones (THs) regulate many developmental processes, including the developmental onset of cochlear differentiation and function. TH action is mediated mostly by triiodothyronine (T3) bound to thyroid hormone nuclear receptors (TRs). At positive regulated genes and in the absence of THs, nuclear co-repressors are bound to TRs and decrease basal transcription rate. Ligand (T(3)) binding results in the dissociation of co-repressors and the recruitment of co-activators to the complex, which results in full transcriptional activation.",
keywords = "Animals, Mice, Mice, Inbred C57BL, Mutation, Amino Acid Substitution, Protein Binding, Gene Knock-In Techniques, Mice, Inbred CBA, Auditory Threshold, *Cochlea/anatomy & histology/physiology, Thyroid Hormone Receptors beta/genetics/*metabolism, Triiodothyronine/metabolism, Animals, Mice, Mice, Inbred C57BL, Mutation, Amino Acid Substitution, Protein Binding, Gene Knock-In Techniques, Mice, Inbred CBA, Auditory Threshold, *Cochlea/anatomy & histology/physiology, Thyroid Hormone Receptors beta/genetics/*metabolism, Triiodothyronine/metabolism",
author = "Claus-Peter Richter and Adrian M{\"u}nscher and Machado, {Danielle Santana} and Wondisford, {Fredric E} and Ortiga-Carvalho, {Tania M}",
year = "2011",
language = "English",
volume = "28",
pages = "997--1008",
journal = "CELL PHYSIOL BIOCHEM",
issn = "1015-8987",
publisher = "S. Karger AG",
number = "5",

}

RIS

TY - JOUR

T1 - Complete activation of thyroid hormone receptor β by T3 is essential for normal cochlear function and morphology in mice.

AU - Richter, Claus-Peter

AU - Münscher, Adrian

AU - Machado, Danielle Santana

AU - Wondisford, Fredric E

AU - Ortiga-Carvalho, Tania M

PY - 2011

Y1 - 2011

N2 - Thyroid hormones (THs) regulate many developmental processes, including the developmental onset of cochlear differentiation and function. TH action is mediated mostly by triiodothyronine (T3) bound to thyroid hormone nuclear receptors (TRs). At positive regulated genes and in the absence of THs, nuclear co-repressors are bound to TRs and decrease basal transcription rate. Ligand (T(3)) binding results in the dissociation of co-repressors and the recruitment of co-activators to the complex, which results in full transcriptional activation.

AB - Thyroid hormones (THs) regulate many developmental processes, including the developmental onset of cochlear differentiation and function. TH action is mediated mostly by triiodothyronine (T3) bound to thyroid hormone nuclear receptors (TRs). At positive regulated genes and in the absence of THs, nuclear co-repressors are bound to TRs and decrease basal transcription rate. Ligand (T(3)) binding results in the dissociation of co-repressors and the recruitment of co-activators to the complex, which results in full transcriptional activation.

KW - Animals

KW - Mice

KW - Mice, Inbred C57BL

KW - Mutation

KW - Amino Acid Substitution

KW - Protein Binding

KW - Gene Knock-In Techniques

KW - Mice, Inbred CBA

KW - Auditory Threshold

KW - Cochlea/anatomy & histology/physiology

KW - Thyroid Hormone Receptors beta/genetics/metabolism

KW - Triiodothyronine/metabolism

KW - Animals

KW - Mice

KW - Mice, Inbred C57BL

KW - Mutation

KW - Amino Acid Substitution

KW - Protein Binding

KW - Gene Knock-In Techniques

KW - Mice, Inbred CBA

KW - Auditory Threshold

KW - Cochlea/anatomy & histology/physiology

KW - Thyroid Hormone Receptors beta/genetics/metabolism

KW - Triiodothyronine/metabolism

M3 - SCORING: Journal article

VL - 28

SP - 997

EP - 1008

JO - CELL PHYSIOL BIOCHEM

JF - CELL PHYSIOL BIOCHEM

SN - 1015-8987

IS - 5

M1 - 5

ER -