Complement Inhibitors in Clinical Trials for Glomerular Diseases
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Complement Inhibitors in Clinical Trials for Glomerular Diseases. / Zipfel, Peter F; Wiech, Thorsten; Rudnick, Ramona; Afonso, Sara; Person, Fermin; Skerka, Christine.
In: FRONT IMMUNOL, Vol. 10, 2019, p. 2166.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Complement Inhibitors in Clinical Trials for Glomerular Diseases
AU - Zipfel, Peter F
AU - Wiech, Thorsten
AU - Rudnick, Ramona
AU - Afonso, Sara
AU - Person, Fermin
AU - Skerka, Christine
N1 - Copyright © 2019 Zipfel, Wiech, Rudnick, Afonso, Person and Skerka.
PY - 2019
Y1 - 2019
N2 - Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov).
AB - Defective complement action is a cause of several human glomerular diseases including atypical hemolytic uremic syndrome (aHUS), anti-neutrophil cytoplasmic antibody mediated vasculitis (ANCA), C3 glomerulopathy, IgA nephropathy, immune complex membranoproliferative glomerulonephritis, ischemic reperfusion injury, lupus nephritis, membranous nephropathy, and chronic transplant mediated glomerulopathy. Here we summarize ongoing clinical trials of complement inhibitors in nine glomerular diseases and show which inhibitors are used in trials for these renal disorders (http://clinicaltrials.gov).
U2 - 10.3389/fimmu.2019.02166
DO - 10.3389/fimmu.2019.02166
M3 - SCORING: Review article
C2 - 31611870
VL - 10
SP - 2166
JO - FRONT IMMUNOL
JF - FRONT IMMUNOL
SN - 1664-3224
ER -