Complaints of sleep disturbances are associated with cardiovascular disease: results from the Gutenberg Health Study
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Complaints of sleep disturbances are associated with cardiovascular disease: results from the Gutenberg Health Study. / Michal, Matthias; Wiltink, Jörg; Kirschner, Yvonne; Schneider, Astrid; Wild, Philipp S; Münzel, Thomas; Blettner, Maria; Schulz, Andreas; Lackner, Karl; Pfeiffer, Norbert; Blankenberg, Stefan; Tschan, Regine; Tuin, Inka; Beutel, Manfred E.
In: PLOS ONE, Vol. 9, No. 8, 2014, p. e104324.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Complaints of sleep disturbances are associated with cardiovascular disease: results from the Gutenberg Health Study
AU - Michal, Matthias
AU - Wiltink, Jörg
AU - Kirschner, Yvonne
AU - Schneider, Astrid
AU - Wild, Philipp S
AU - Münzel, Thomas
AU - Blettner, Maria
AU - Schulz, Andreas
AU - Lackner, Karl
AU - Pfeiffer, Norbert
AU - Blankenberg, Stefan
AU - Tschan, Regine
AU - Tuin, Inka
AU - Beutel, Manfred E
PY - 2014
Y1 - 2014
N2 - BACKGROUND: Despite their high prevalence, sleep disorders often remain unrecognized and untreated because of barriers to assessment and management. The aims of the present study were to examine associations of complaints of sleep disturbances with cardiovascular disease, related risk factors, and inflammation in the community and to determine the contribution of sleep disturbances to self-perceived physical health.METHOD: The sample consists of n = 10.000 participants, aged 35 to 74 years of a population based community sample in Germany. Cross-sectional associations of complaints of sleep disturbances with cardiovascular risk factors and disease, biomarkers of inflammation, depression, anxiety, and physical health status were analyzed.RESULTS: 19% of our sample endorsed clinically significant sleep disturbances. In the unadjusted analyses severity of sleep disturbances increased with female sex, low socioeconomic status, living without a partnership, cardiovascular disease, depression, anxiety, poor physical health, increased levels of C-reactive protein and fibrinogen. After multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained. Complaints of sleep disturbances were strong and independent contributors to self-perceived poor physical health beyond depression, anxiety and medical disease burden.CONCLUSIONS: Given the high prevalence of complaints of sleep disturbances and their strong impact on health status, increased efforts should be undertaken for their identification and treatment.
AB - BACKGROUND: Despite their high prevalence, sleep disorders often remain unrecognized and untreated because of barriers to assessment and management. The aims of the present study were to examine associations of complaints of sleep disturbances with cardiovascular disease, related risk factors, and inflammation in the community and to determine the contribution of sleep disturbances to self-perceived physical health.METHOD: The sample consists of n = 10.000 participants, aged 35 to 74 years of a population based community sample in Germany. Cross-sectional associations of complaints of sleep disturbances with cardiovascular risk factors and disease, biomarkers of inflammation, depression, anxiety, and physical health status were analyzed.RESULTS: 19% of our sample endorsed clinically significant sleep disturbances. In the unadjusted analyses severity of sleep disturbances increased with female sex, low socioeconomic status, living without a partnership, cardiovascular disease, depression, anxiety, poor physical health, increased levels of C-reactive protein and fibrinogen. After multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained. Complaints of sleep disturbances were strong and independent contributors to self-perceived poor physical health beyond depression, anxiety and medical disease burden.CONCLUSIONS: Given the high prevalence of complaints of sleep disturbances and their strong impact on health status, increased efforts should be undertaken for their identification and treatment.
KW - Adult
KW - Aged
KW - Biomarkers
KW - Cardiovascular Diseases/complications
KW - Comorbidity
KW - Cross-Sectional Studies
KW - Female
KW - Germany/epidemiology
KW - Health Status
KW - Humans
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Risk Factors
KW - Severity of Illness Index
KW - Sleep Wake Disorders/diagnosis
KW - Surveys and Questionnaires
U2 - 10.1371/journal.pone.0104324
DO - 10.1371/journal.pone.0104324
M3 - SCORING: Journal article
C2 - 25093413
VL - 9
SP - e104324
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 8
ER -
