Research ExplorerPublicationsCompartmentation of NAD+-dependent signalling.

Compartmentation of NAD+-dependent signalling.

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Compartmentation of NAD+-dependent signalling. / Koch Nolte, Friedrich; Fischer, Stefan; Haag, Friedrich; Ziegler, Mathias.

In: FEBS LETT, Vol. 585, No. 11, 11, 2011, p. 1651-1656.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Koch Nolte, F, Fischer, S, Haag, F & Ziegler, M 2011, 'Compartmentation of NAD+-dependent signalling.', FEBS LETT, vol. 585, no. 11, 11, pp. 1651-1656. <http://www.ncbi.nlm.nih.gov/pubmed/21443875?dopt=Citation>

APA

Koch Nolte, F., Fischer, S., Haag, F., & Ziegler, M. (2011). Compartmentation of NAD+-dependent signalling. FEBS LETT, 585(11), 1651-1656. [11]. http://www.ncbi.nlm.nih.gov/pubmed/21443875?dopt=Citation

Vancouver

Koch Nolte F, Fischer S, Haag F, Ziegler M. Compartmentation of NAD+-dependent signalling. FEBS LETT. 2011;585(11):1651-1656. 11.

Bibtex

@article{7c77a967b9ab4444b0f234a5c3115726,
title = "Compartmentation of NAD+-dependent signalling.",
abstract = "NAD(+) plays central roles in energy metabolism as redox carrier. Recent research has identified important signalling functions of NAD(+) that involve its consumption. Although NAD(+) is synthesized mainly in the cytosol, nucleus and mitochondria, it has been detected also in vesicular and extracellular compartments. Three protein families that consume NAD(+) in signalling reactions have been characterized on a molecular level: ADP-ribosyltransferases (ARTs), Sirtuins (SIRTs), and NAD(+) glycohydrolases (NADases). Members of these families serve important regulatory functions in various cellular compartments, e.g., by linking the cellular energy state to gene expression in the nucleus, by regulating nitrogen metabolism in mitochondria, and by sensing tissue damage in the extracellular compartment. Distinct NAD(+) pools may be crucial for these processes. Here, we review the current knowledge about the compartmentation and biochemistry of NAD(+)-converting enzymes that control NAD(+) signalling.",
keywords = "Animals, Humans, *Signal Transduction, Proteins/metabolism, *Cell Compartmentation, Extracellular Space/metabolism, Intracellular Space/metabolism, NAD/*metabolism, Animals, Humans, *Signal Transduction, Proteins/metabolism, *Cell Compartmentation, Extracellular Space/metabolism, Intracellular Space/metabolism, NAD/*metabolism",
author = "{Koch Nolte}, Friedrich and Stefan Fischer and Friedrich Haag and Mathias Ziegler",
year = "2011",
language = "English",
volume = "585",
pages = "1651--1656",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Compartmentation of NAD+-dependent signalling.

AU - Koch Nolte, Friedrich

AU - Fischer, Stefan

AU - Haag, Friedrich

AU - Ziegler, Mathias

PY - 2011

Y1 - 2011

N2 - NAD(+) plays central roles in energy metabolism as redox carrier. Recent research has identified important signalling functions of NAD(+) that involve its consumption. Although NAD(+) is synthesized mainly in the cytosol, nucleus and mitochondria, it has been detected also in vesicular and extracellular compartments. Three protein families that consume NAD(+) in signalling reactions have been characterized on a molecular level: ADP-ribosyltransferases (ARTs), Sirtuins (SIRTs), and NAD(+) glycohydrolases (NADases). Members of these families serve important regulatory functions in various cellular compartments, e.g., by linking the cellular energy state to gene expression in the nucleus, by regulating nitrogen metabolism in mitochondria, and by sensing tissue damage in the extracellular compartment. Distinct NAD(+) pools may be crucial for these processes. Here, we review the current knowledge about the compartmentation and biochemistry of NAD(+)-converting enzymes that control NAD(+) signalling.

AB - NAD(+) plays central roles in energy metabolism as redox carrier. Recent research has identified important signalling functions of NAD(+) that involve its consumption. Although NAD(+) is synthesized mainly in the cytosol, nucleus and mitochondria, it has been detected also in vesicular and extracellular compartments. Three protein families that consume NAD(+) in signalling reactions have been characterized on a molecular level: ADP-ribosyltransferases (ARTs), Sirtuins (SIRTs), and NAD(+) glycohydrolases (NADases). Members of these families serve important regulatory functions in various cellular compartments, e.g., by linking the cellular energy state to gene expression in the nucleus, by regulating nitrogen metabolism in mitochondria, and by sensing tissue damage in the extracellular compartment. Distinct NAD(+) pools may be crucial for these processes. Here, we review the current knowledge about the compartmentation and biochemistry of NAD(+)-converting enzymes that control NAD(+) signalling.

KW - Animals

KW - Humans

KW - Signal Transduction

KW - Proteins/metabolism

KW - Cell Compartmentation

KW - Extracellular Space/metabolism

KW - Intracellular Space/metabolism

KW - NAD/metabolism

KW - Animals

KW - Humans

KW - Signal Transduction

KW - Proteins/metabolism

KW - Cell Compartmentation

KW - Extracellular Space/metabolism

KW - Intracellular Space/metabolism

KW - NAD/metabolism

M3 - SCORING: Journal article

VL - 585

SP - 1651

EP - 1656

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 11

M1 - 11

ER -