Compartmental resection for subfascial extremity soft tissue sarcoma and quality of life in long-term survivors.
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Compartmental resection for subfascial extremity soft tissue sarcoma and quality of life in long-term survivors. / Peiper, Mathias; Matthaei, Hanno; Bölke, Edwin; Zurakowski, David; Orth, Klaus; Heinecke, Antje; Knoefel, Wolfram-Trudo.
In: WIEN KLIN WOCHENSCHR, Vol. 123, No. 15-16, 15-16, 2011, p. 488-495.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Compartmental resection for subfascial extremity soft tissue sarcoma and quality of life in long-term survivors.
AU - Peiper, Mathias
AU - Matthaei, Hanno
AU - Bölke, Edwin
AU - Zurakowski, David
AU - Orth, Klaus
AU - Heinecke, Antje
AU - Knoefel, Wolfram-Trudo
PY - 2011
Y1 - 2011
N2 - The surgical management of soft tissue sarcoma has changed over the past years, resulting in an interdisciplinary multimodal approach and limb-preserving treatment modalities. From 464 consecutive patients with a soft tissue sarcoma (STS) of an extremity, a compartmental resection was performed in 82 patients, usually for primary subfascial large tumors. Postoperative quality of life was evaluated using the EORTC Score C30. In our study population, 52% of STS was poorly differentiated, 32% moderately, and 16% well differentiated. Survival proved to be dependent on tumor grade and tumor biology, but not on tumor size. The overall survival rate was 81.5%, 71.9%, and 58.3% after 2, 3, and 5 years, respectively. Leiomyosarcoma (39%) and malignant fibrous histiocytoma (42%) are associated with poor 5-year survival rate compared to liposarcoma (82%). Metastases were observed in 33% of T1 and 43% of T2 tumors corresponding to 51% with G3 tumors, 52% with G2 and 23% with G1 tumors. We found a decreased quality of life score in our patients in all dimensions compared to a normal population. Despite the elevated risk of a functional deficit, compartmental resection reduces the risk of local recurrence comparable to the recurrence rates after the most radical surgery limb amputation.
AB - The surgical management of soft tissue sarcoma has changed over the past years, resulting in an interdisciplinary multimodal approach and limb-preserving treatment modalities. From 464 consecutive patients with a soft tissue sarcoma (STS) of an extremity, a compartmental resection was performed in 82 patients, usually for primary subfascial large tumors. Postoperative quality of life was evaluated using the EORTC Score C30. In our study population, 52% of STS was poorly differentiated, 32% moderately, and 16% well differentiated. Survival proved to be dependent on tumor grade and tumor biology, but not on tumor size. The overall survival rate was 81.5%, 71.9%, and 58.3% after 2, 3, and 5 years, respectively. Leiomyosarcoma (39%) and malignant fibrous histiocytoma (42%) are associated with poor 5-year survival rate compared to liposarcoma (82%). Metastases were observed in 33% of T1 and 43% of T2 tumors corresponding to 51% with G3 tumors, 52% with G2 and 23% with G1 tumors. We found a decreased quality of life score in our patients in all dimensions compared to a normal population. Despite the elevated risk of a functional deficit, compartmental resection reduces the risk of local recurrence comparable to the recurrence rates after the most radical surgery limb amputation.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Survivors
KW - Retrospective Studies
KW - Cooperative Behavior
KW - Patient Care Team
KW - Interdisciplinary Communication
KW - Neoplasm Grading
KW - Quality of Life/psychology
KW - Extremities/pathology/surgery
KW - Fascia/pathology/surgery
KW - Histiocytoma, Malignant Fibrous/pathology/surgery
KW - Leiomyosarcoma/pathology/surgery
KW - Limb Salvage/methods
KW - Liposarcoma/pathology/surgery
KW - Postoperative Complications/psychology
KW - Sarcoma/pathology/surgery
KW - Soft Tissue Neoplasms/pathology/surgery
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Survivors
KW - Retrospective Studies
KW - Cooperative Behavior
KW - Patient Care Team
KW - Interdisciplinary Communication
KW - Neoplasm Grading
KW - Quality of Life/psychology
KW - Extremities/pathology/surgery
KW - Fascia/pathology/surgery
KW - Histiocytoma, Malignant Fibrous/pathology/surgery
KW - Leiomyosarcoma/pathology/surgery
KW - Limb Salvage/methods
KW - Liposarcoma/pathology/surgery
KW - Postoperative Complications/psychology
KW - Sarcoma/pathology/surgery
KW - Soft Tissue Neoplasms/pathology/surgery
M3 - SCORING: Journal article
VL - 123
SP - 488
EP - 495
JO - WIEN KLIN WOCHENSCHR
JF - WIEN KLIN WOCHENSCHR
SN - 0043-5325
IS - 15-16
M1 - 15-16
ER -
