Comparison of three clinical rating scales in Friedreich ataxia (FRDA).
Standard
Comparison of three clinical rating scales in Friedreich ataxia (FRDA). / Bürk, Katrin; Mälzig, Ulrike; Wolf, Stefanie; Heck, Suzette; Dimitriadis, Konstantinos; Schmitz-Hübsch, Tanja; Hering, Sascha; Lindig, Tobias M; Haug, Verena; Timmann, Dagmar; Degen, Ingrid; Kruse, Bernd; Dörr, Jan-Markus; Ratzka, Susanne; Ivo, Anja; Schöls, Ludger; Boesch, Sylvia; Klockgether, Thomas; Klopstock, Thomas; Schulz, Jörg B.
In: MOVEMENT DISORD, 2009.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Comparison of three clinical rating scales in Friedreich ataxia (FRDA).
AU - Bürk, Katrin
AU - Mälzig, Ulrike
AU - Wolf, Stefanie
AU - Heck, Suzette
AU - Dimitriadis, Konstantinos
AU - Schmitz-Hübsch, Tanja
AU - Hering, Sascha
AU - Lindig, Tobias M
AU - Haug, Verena
AU - Timmann, Dagmar
AU - Degen, Ingrid
AU - Kruse, Bernd
AU - Dörr, Jan-Markus
AU - Ratzka, Susanne
AU - Ivo, Anja
AU - Schöls, Ludger
AU - Boesch, Sylvia
AU - Klockgether, Thomas
AU - Klopstock, Thomas
AU - Schulz, Jörg B
PY - 2009
Y1 - 2009
N2 - To test the validity and reliability of the scale for the assessment and rating of ataxia (SARA) in Friedreich ataxia (FRDA). SARA is limited to eight items and can be performed rapidly. Ninety-six patients with a molecular genetic diagnosis of FRDA were rated using three different clinical scales, the FRDA Rating Scale (FARS), the International Cooperative Ataxia Rating Scale (ICARS), and SARA. Despite considerable discrepancies in scale size and subscale structure, SARA total scores were significantly correlated with ICARS (r = 0.953, P <0.0001) and FARS (r = 0.938, P <0.0001) total scores. SARA total scores also correlated with the activities of daily living (ADL, r = 0.929, P <0.0001). Although originally developed for the use in dominantly inherited ataxias, which are primarily ataxias of the cerebellar type, SARA can also be used successfully to assess afferent ataxia, which is the predominant form in FRDA. Because SARA is characterized by high interrater reliability and practicability, SARA is applicable and well suited forclinical trials of FRDA. (c) 2009 Movement Disorder Society.
AB - To test the validity and reliability of the scale for the assessment and rating of ataxia (SARA) in Friedreich ataxia (FRDA). SARA is limited to eight items and can be performed rapidly. Ninety-six patients with a molecular genetic diagnosis of FRDA were rated using three different clinical scales, the FRDA Rating Scale (FARS), the International Cooperative Ataxia Rating Scale (ICARS), and SARA. Despite considerable discrepancies in scale size and subscale structure, SARA total scores were significantly correlated with ICARS (r = 0.953, P <0.0001) and FARS (r = 0.938, P <0.0001) total scores. SARA total scores also correlated with the activities of daily living (ADL, r = 0.929, P <0.0001). Although originally developed for the use in dominantly inherited ataxias, which are primarily ataxias of the cerebellar type, SARA can also be used successfully to assess afferent ataxia, which is the predominant form in FRDA. Because SARA is characterized by high interrater reliability and practicability, SARA is applicable and well suited forclinical trials of FRDA. (c) 2009 Movement Disorder Society.
M3 - SCORING: Journal article
JO - MOVEMENT DISORD
JF - MOVEMENT DISORD
SN - 0885-3185
ER -