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Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas

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Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas. / Karstens, Karl-Frederick; Ghadban, Tarik; Sawez, Sahar; Konczalla, Leonie; Woestemeier, Anna; Bachmann, Kai; Uzunoglu, Faik G; Tachezy, Michael; Vettorazzi, Eik; Izbicki, Jakob R; Reeh, Matthias.

In: EJSO-EUR J SURG ONC, Vol. 46, No. 4 Pt A, 04.2020, p. 638-643.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Karstens, K-F, Ghadban, T, Sawez, S, Konczalla, L, Woestemeier, A, Bachmann, K, Uzunoglu, FG, Tachezy, M, Vettorazzi, E, Izbicki, JR & Reeh, M 2020, 'Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas', EJSO-EUR J SURG ONC, vol. 46, no. 4 Pt A, pp. 638-643. https://doi.org/10.1016/j.ejso.2019.12.011

APA

Karstens, K-F., Ghadban, T., Sawez, S., Konczalla, L., Woestemeier, A., Bachmann, K., Uzunoglu, F. G., Tachezy, M., Vettorazzi, E., Izbicki, J. R., & Reeh, M. (2020). Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas. EJSO-EUR J SURG ONC, 46(4 Pt A), 638-643. https://doi.org/10.1016/j.ejso.2019.12.011

Vancouver

Karstens K-F, Ghadban T, Sawez S, Konczalla L, Woestemeier A, Bachmann K et al. Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas. EJSO-EUR J SURG ONC. 2020 Apr;46(4 Pt A):638-643. https://doi.org/10.1016/j.ejso.2019.12.011

Bibtex

@article{85c9af9fd5d74637b231b19a7897e0d4,
title = "Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas",
abstract = "BACKGROUND: The aim of this study is to evaluate whether adenocarcinomas of the esophagogastric junction (AEG) are better staged as cancers of the esophagus (TNM-EC) or stomach (TNM-GC) according to the 8th edition of the UICC classification.METHODS: A single-center cohort of 246 patients operated on for AEG type II was staged according to the 8th edition of the UICC classification for esophageal and stomach cancer. Kaplan-Meier and univariate Cox regression analyses were performed to investigate the impact on survival.RESULTS: For AEG type II TNM-EC classified most of the patients (n = 126; 51.2%) to UICC stage IIIC and IVA while TNM-GC more evenly distributed the patients over the stages. Hazard ratios increased in between all stages in a stepwise manner except between stage IA and IIA for TNM-EC and between stage IIB and IIIA for TNM-GC. Survival curves for TNM-GC demonstrated significant differences between all four major UICC stages, while in TNM-EC no significant difference between stage I and II was found. When comparing the area under the curves of both staging systems a marginal superiority for TNM-EC was found.CONCLUSION: Neither the esophageal nor the stomach staging system is flawless in predicting survival in AEG type II. A marginal superiority of the TNM-EC was found in discriminating survival rates after three and five years. However, the advantage of the TNM-GC lies in the division of the N3 category into N3a and N3b. We therefor suggest a similar division in future TNM-EC classifications to improve its prognostic value.",
author = "Karl-Frederick Karstens and Tarik Ghadban and Sahar Sawez and Leonie Konczalla and Anna Woestemeier and Kai Bachmann and Uzunoglu, {Faik G} and Michael Tachezy and Eik Vettorazzi and Izbicki, {Jakob R} and Matthias Reeh",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.",
year = "2020",
month = apr,
doi = "10.1016/j.ejso.2019.12.011",
language = "English",
volume = "46",
pages = "638--643",
journal = "EJSO-EUR J SURG ONC",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "4 Pt A",

}

RIS

TY - JOUR

T1 - Comparison of the 8th UICC staging system for esophageal and gastric cancers in Siewert type II junctional adenocarcinomas

AU - Karstens, Karl-Frederick

AU - Ghadban, Tarik

AU - Sawez, Sahar

AU - Konczalla, Leonie

AU - Woestemeier, Anna

AU - Bachmann, Kai

AU - Uzunoglu, Faik G

AU - Tachezy, Michael

AU - Vettorazzi, Eik

AU - Izbicki, Jakob R

AU - Reeh, Matthias

N1 - Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

PY - 2020/4

Y1 - 2020/4

N2 - BACKGROUND: The aim of this study is to evaluate whether adenocarcinomas of the esophagogastric junction (AEG) are better staged as cancers of the esophagus (TNM-EC) or stomach (TNM-GC) according to the 8th edition of the UICC classification.METHODS: A single-center cohort of 246 patients operated on for AEG type II was staged according to the 8th edition of the UICC classification for esophageal and stomach cancer. Kaplan-Meier and univariate Cox regression analyses were performed to investigate the impact on survival.RESULTS: For AEG type II TNM-EC classified most of the patients (n = 126; 51.2%) to UICC stage IIIC and IVA while TNM-GC more evenly distributed the patients over the stages. Hazard ratios increased in between all stages in a stepwise manner except between stage IA and IIA for TNM-EC and between stage IIB and IIIA for TNM-GC. Survival curves for TNM-GC demonstrated significant differences between all four major UICC stages, while in TNM-EC no significant difference between stage I and II was found. When comparing the area under the curves of both staging systems a marginal superiority for TNM-EC was found.CONCLUSION: Neither the esophageal nor the stomach staging system is flawless in predicting survival in AEG type II. A marginal superiority of the TNM-EC was found in discriminating survival rates after three and five years. However, the advantage of the TNM-GC lies in the division of the N3 category into N3a and N3b. We therefor suggest a similar division in future TNM-EC classifications to improve its prognostic value.

AB - BACKGROUND: The aim of this study is to evaluate whether adenocarcinomas of the esophagogastric junction (AEG) are better staged as cancers of the esophagus (TNM-EC) or stomach (TNM-GC) according to the 8th edition of the UICC classification.METHODS: A single-center cohort of 246 patients operated on for AEG type II was staged according to the 8th edition of the UICC classification for esophageal and stomach cancer. Kaplan-Meier and univariate Cox regression analyses were performed to investigate the impact on survival.RESULTS: For AEG type II TNM-EC classified most of the patients (n = 126; 51.2%) to UICC stage IIIC and IVA while TNM-GC more evenly distributed the patients over the stages. Hazard ratios increased in between all stages in a stepwise manner except between stage IA and IIA for TNM-EC and between stage IIB and IIIA for TNM-GC. Survival curves for TNM-GC demonstrated significant differences between all four major UICC stages, while in TNM-EC no significant difference between stage I and II was found. When comparing the area under the curves of both staging systems a marginal superiority for TNM-EC was found.CONCLUSION: Neither the esophageal nor the stomach staging system is flawless in predicting survival in AEG type II. A marginal superiority of the TNM-EC was found in discriminating survival rates after three and five years. However, the advantage of the TNM-GC lies in the division of the N3 category into N3a and N3b. We therefor suggest a similar division in future TNM-EC classifications to improve its prognostic value.

U2 - 10.1016/j.ejso.2019.12.011

DO - 10.1016/j.ejso.2019.12.011

M3 - SCORING: Journal article

C2 - 31879051

VL - 46

SP - 638

EP - 643

JO - EJSO-EUR J SURG ONC

JF - EJSO-EUR J SURG ONC

SN - 0748-7983

IS - 4 Pt A

ER -