Research ExplorerPublicationsComparison of Perfusion CT Software to Predict the Final Inf...

Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy

Standard

Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy. / Austein, Friederike; Riedel, Christian; Kerby, Tina; Meyne, Johannes; Binder, Andreas; Lindner, Thomas; Huhndorf, Monika; Wodarg, Fritz; Jansen, Olav.

In: STROKE, Vol. 47, No. 9, 09.2016, p. 2311-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Austein, F, Riedel, C, Kerby, T, Meyne, J, Binder, A, Lindner, T, Huhndorf, M, Wodarg, F & Jansen, O 2016, 'Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy', STROKE, vol. 47, no. 9, pp. 2311-7. https://doi.org/10.1161/STROKEAHA.116.013147

APA

Austein, F., Riedel, C., Kerby, T., Meyne, J., Binder, A., Lindner, T., Huhndorf, M., Wodarg, F., & Jansen, O. (2016). Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy. STROKE, 47(9), 2311-7. https://doi.org/10.1161/STROKEAHA.116.013147

Vancouver

Austein F, Riedel C, Kerby T, Meyne J, Binder A, Lindner T et al. Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy. STROKE. 2016 Sep;47(9):2311-7. https://doi.org/10.1161/STROKEAHA.116.013147

Bibtex

@article{6de970818abd4291b8859a7ca0ac844e,
title = "Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy",
abstract = "BACKGROUND AND PURPOSE: Computed tomographic perfusion represents an interesting physiological imaging modality to select patients for reperfusion therapy in acute ischemic stroke. The purpose of our study was to determine the accuracy of different commercial perfusion CT software packages (Philips (A), Siemens (B), and RAPID (C)) to predict the final infarct volume (FIV) after mechanical thrombectomy.METHODS: Single-institutional computed tomographic perfusion data from 147 mechanically recanalized acute ischemic stroke patients were postprocessed. Ischemic core and FIV were compared about thrombolysis in cerebral infarction (TICI) score and time interval to reperfusion. FIV was measured at follow-up imaging between days 1 and 8 after stroke.RESULTS: In 118 successfully recanalized patients (TICI 2b/3), a moderately to strongly positive correlation was observed between ischemic core and FIV. The highest accuracy and best correlation are shown in early and fully recanalized patients (Pearson r for A=0.42, B=0.64, and C=0.83; P<0.001). Bland-Altman plots and boxplots demonstrate smaller ranges in package C than in A and B. Significant differences were found between the packages about over- and underestimation of the ischemic core. Package A, compared with B and C, estimated more than twice as many patients with a malignant stroke profile (P<0.001). Package C best predicted hypoperfusion volume in nonsuccessfully recanalized patients.CONCLUSIONS: Our study demonstrates best accuracy and approximation between the results of a fully automated software (RAPID) and FIV, especially in early and fully recanalized patients. Furthermore, this software package overestimated the FIV to a significantly lower degree and estimated a malignant mismatch profile less often than other software.",
keywords = "Aged, Aged, 80 and over, Brain/diagnostic imaging, Brain Ischemia/diagnostic imaging, Female, Humans, Image Processing, Computer-Assisted/methods, Male, Middle Aged, Perfusion Imaging/methods, Retrospective Studies, Software, Stroke/diagnostic imaging, Thrombectomy, Tomography, X-Ray Computed, Treatment Outcome",
author = "Friederike Austein and Christian Riedel and Tina Kerby and Johannes Meyne and Andreas Binder and Thomas Lindner and Monika Huhndorf and Fritz Wodarg and Olav Jansen",
note = "{\textcopyright} 2016 American Heart Association, Inc.",
year = "2016",
month = sep,
doi = "10.1161/STROKEAHA.116.013147",
language = "English",
volume = "47",
pages = "2311--7",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Comparison of Perfusion CT Software to Predict the Final Infarct Volume After Thrombectomy

AU - Austein, Friederike

AU - Riedel, Christian

AU - Kerby, Tina

AU - Meyne, Johannes

AU - Binder, Andreas

AU - Lindner, Thomas

AU - Huhndorf, Monika

AU - Wodarg, Fritz

AU - Jansen, Olav

N1 - © 2016 American Heart Association, Inc.

PY - 2016/9

Y1 - 2016/9

N2 - BACKGROUND AND PURPOSE: Computed tomographic perfusion represents an interesting physiological imaging modality to select patients for reperfusion therapy in acute ischemic stroke. The purpose of our study was to determine the accuracy of different commercial perfusion CT software packages (Philips (A), Siemens (B), and RAPID (C)) to predict the final infarct volume (FIV) after mechanical thrombectomy.METHODS: Single-institutional computed tomographic perfusion data from 147 mechanically recanalized acute ischemic stroke patients were postprocessed. Ischemic core and FIV were compared about thrombolysis in cerebral infarction (TICI) score and time interval to reperfusion. FIV was measured at follow-up imaging between days 1 and 8 after stroke.RESULTS: In 118 successfully recanalized patients (TICI 2b/3), a moderately to strongly positive correlation was observed between ischemic core and FIV. The highest accuracy and best correlation are shown in early and fully recanalized patients (Pearson r for A=0.42, B=0.64, and C=0.83; P<0.001). Bland-Altman plots and boxplots demonstrate smaller ranges in package C than in A and B. Significant differences were found between the packages about over- and underestimation of the ischemic core. Package A, compared with B and C, estimated more than twice as many patients with a malignant stroke profile (P<0.001). Package C best predicted hypoperfusion volume in nonsuccessfully recanalized patients.CONCLUSIONS: Our study demonstrates best accuracy and approximation between the results of a fully automated software (RAPID) and FIV, especially in early and fully recanalized patients. Furthermore, this software package overestimated the FIV to a significantly lower degree and estimated a malignant mismatch profile less often than other software.

AB - BACKGROUND AND PURPOSE: Computed tomographic perfusion represents an interesting physiological imaging modality to select patients for reperfusion therapy in acute ischemic stroke. The purpose of our study was to determine the accuracy of different commercial perfusion CT software packages (Philips (A), Siemens (B), and RAPID (C)) to predict the final infarct volume (FIV) after mechanical thrombectomy.METHODS: Single-institutional computed tomographic perfusion data from 147 mechanically recanalized acute ischemic stroke patients were postprocessed. Ischemic core and FIV were compared about thrombolysis in cerebral infarction (TICI) score and time interval to reperfusion. FIV was measured at follow-up imaging between days 1 and 8 after stroke.RESULTS: In 118 successfully recanalized patients (TICI 2b/3), a moderately to strongly positive correlation was observed between ischemic core and FIV. The highest accuracy and best correlation are shown in early and fully recanalized patients (Pearson r for A=0.42, B=0.64, and C=0.83; P<0.001). Bland-Altman plots and boxplots demonstrate smaller ranges in package C than in A and B. Significant differences were found between the packages about over- and underestimation of the ischemic core. Package A, compared with B and C, estimated more than twice as many patients with a malignant stroke profile (P<0.001). Package C best predicted hypoperfusion volume in nonsuccessfully recanalized patients.CONCLUSIONS: Our study demonstrates best accuracy and approximation between the results of a fully automated software (RAPID) and FIV, especially in early and fully recanalized patients. Furthermore, this software package overestimated the FIV to a significantly lower degree and estimated a malignant mismatch profile less often than other software.

KW - Aged

KW - Aged, 80 and over

KW - Brain/diagnostic imaging

KW - Brain Ischemia/diagnostic imaging

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted/methods

KW - Male

KW - Middle Aged

KW - Perfusion Imaging/methods

KW - Retrospective Studies

KW - Software

KW - Stroke/diagnostic imaging

KW - Thrombectomy

KW - Tomography, X-Ray Computed

KW - Treatment Outcome

U2 - 10.1161/STROKEAHA.116.013147

DO - 10.1161/STROKEAHA.116.013147

M3 - SCORING: Journal article

C2 - 27507864

VL - 47

SP - 2311

EP - 2317

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 9

ER -