Comparison of morphometric analysis based on T1- and T2-weighted MRI data for visualization of focal cortical dysplasia

TY - JOUR

T1 - Comparison of morphometric analysis based on T1- and T2-weighted MRI data for visualization of focal cortical dysplasia

AU - House, Patrick M

AU - Lanz, Michael

AU - Holst, Brigitte

AU - Martens, Tobias

AU - Stodieck, Stefan

AU - Huppertz, Hans-Jürgen

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - PURPOSE: Focal cortical dysplasias (FCD) are highly epileptogenic lesions frequently accounting for pharmaco-resistant focal epilepsy. Visual MRI analysis combined with morphometric analysis of T1-weighted MRI data was shown to be of higher diagnostic sensitivity in detecting and delineating FCD than conventional visual analysis alone. Here we investigate whether morphometric analysis of T2-weighted MRI volume data sets is of equal benefit or perhaps more helpful for visualizing FCD.MATERIALS AND METHODS: Morphometric analysis was applied to T1- and T2-weighted MRI volume data sets of 20 epilepsy patients with FCD using a fully automated MATLAB script with scanner- and sequence-specific normal databases for T1 and T2 images. For each modality, a new feature map (i.e., 'junction image') highlighting the FCD-typical blurring of the gray-white matter junction and quantifying this feature in comparison to the normal database in terms of z-scores was calculated. The resulting T1 and T2 'junction images' were compared for conspicuity and recognizability of the FCD both qualitatively by visual assessment and quantitatively by analysis of the mean z-scores inside and outside the lesions.RESULTS: In 80% of the cases, the FCD presented with higher contrast and/or clearer delineation in the T2 than in the T1 'junction images' and were thus easier to recognize in these images. The quantitative analysis supported this impression: in 95% of cases, the ratio of mean z-scores inside and outside the FCD was higher in T2- than in T1-based 'junction images'. For the T2 'junction images', this ratio amounted to 8.7 on average and was thus more than twice as high as the corresponding T1 result of 3.7 (p<.003).CONCLUSION: Concerning visualization of FCD by highlighting blurring of the gray-white matter junction, the results of the present study indicate that morphometric analysis of T2-weighted MRI data on average is superior to T1-based morphometry.

AB - PURPOSE: Focal cortical dysplasias (FCD) are highly epileptogenic lesions frequently accounting for pharmaco-resistant focal epilepsy. Visual MRI analysis combined with morphometric analysis of T1-weighted MRI data was shown to be of higher diagnostic sensitivity in detecting and delineating FCD than conventional visual analysis alone. Here we investigate whether morphometric analysis of T2-weighted MRI volume data sets is of equal benefit or perhaps more helpful for visualizing FCD.MATERIALS AND METHODS: Morphometric analysis was applied to T1- and T2-weighted MRI volume data sets of 20 epilepsy patients with FCD using a fully automated MATLAB script with scanner- and sequence-specific normal databases for T1 and T2 images. For each modality, a new feature map (i.e., 'junction image') highlighting the FCD-typical blurring of the gray-white matter junction and quantifying this feature in comparison to the normal database in terms of z-scores was calculated. The resulting T1 and T2 'junction images' were compared for conspicuity and recognizability of the FCD both qualitatively by visual assessment and quantitatively by analysis of the mean z-scores inside and outside the lesions.RESULTS: In 80% of the cases, the FCD presented with higher contrast and/or clearer delineation in the T2 than in the T1 'junction images' and were thus easier to recognize in these images. The quantitative analysis supported this impression: in 95% of cases, the ratio of mean z-scores inside and outside the FCD was higher in T2- than in T1-based 'junction images'. For the T2 'junction images', this ratio amounted to 8.7 on average and was thus more than twice as high as the corresponding T1 result of 3.7 (p<.003).CONCLUSION: Concerning visualization of FCD by highlighting blurring of the gray-white matter junction, the results of the present study indicate that morphometric analysis of T2-weighted MRI data on average is superior to T1-based morphometry.

KW - Adolescent

KW - Adult

KW - Brain

KW - Databases, Factual

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Malformations of Cortical Development

KW - Middle Aged

KW - Young Adult

U2 - 10.1016/j.eplepsyres.2013.06.016

DO - 10.1016/j.eplepsyres.2013.06.016

M3 - SCORING: Journal article

C2 - 23891304

VL - 106

SP - 403

EP - 409

JO - EPILEPSY RES

JF - EPILEPSY RES

SN - 0920-1211

IS - 3

ER -